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- W3111948799 abstract "Various components of the tumor microenvironment (TME) play a critical role in promoting tumorigenesis, progression, and metastasis. One of the primary functions of the TME is to stimulate an immunosuppressive environment around the tumor through multiple mechanisms including the activation of the transforming growth factor-beta (TGF-β) signaling pathway. Cancer-associated fibroblasts (CAFs) are key cells in the TME that regulate the secretion of extracellular matrix (ECM) components under the influence of TGF-β. Recent reports from our group and others have described an ECM-related and CAF-associated novel gene signature that can predict resistance to immune checkpoint blockade (ICB). Importantly, studies have begun to test whether targeting some of these CAF-associated components can be used as a combinatorial approach with ICB. This perspective summarizes recent advances in our understanding of CAF and TGF-β-regulated immunosuppressive mechanisms and ways to target such signaling in cancer." @default.
- W3111948799 created "2020-12-21" @default.
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- W3111948799 creator A5052352162 @default.
- W3111948799 creator A5077568634 @default.
- W3111948799 date "2020-12-05" @default.
- W3111948799 modified "2023-10-16" @default.
- W3111948799 title "TGF-β Mediated Immune Evasion in Cancer—Spotlight on Cancer-Associated Fibroblasts" @default.
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- W3111948799 doi "https://doi.org/10.3390/cancers12123650" @default.
- W3111948799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7762018" @default.
- W3111948799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33291370" @default.
- W3111948799 hasPublicationYear "2020" @default.
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