FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111964498> ?p ?o ?g. }

• W3111964498 abstract "Abstract Background Objective: To present comprehensive data on the MGH FTD Unit PCA cohort. PCA is a neurodegenerative clinical syndrome usually arising from Alzheimer’s Disease (AD) neuropathologic changes (ADNC). While visuoperceptual and spatial problems are typical early presenting symptoms, patients also report problems with spelling, calculation, and word retrieval. Due to significant heterogeneity in the syndrome, further classification of PCA by subtypes based on predominant cognitive impairments (dorsal, ventral, caudal, dominant parietal) has also been proposed. We launched our multidisciplinary MGH PCA program in 2008 to address the special care needs of this population, and to advance our scientific understanding of PCA and its treatment. Methods 39 participants were recruited for research participation based on clinical diagnostic criteria consistent with PCA, including a dominant hemisphere variant (i.e., progressive Gerstmann‐like syndrome minimal visuospatial disturbance). Participants underwent structured review of symptoms and history; systematic neurological exam; comprehensive neuropsychological and speech‐language assessments; multimodal imaging (MRI and/or functional MRI and FDG, amyloid, and tau PET); and CSF analysis. Some patients have come to autopsy. We used the Neuropsychological Assessment Rating (NAR) scale to quantify performance in cognitive domains pertinent to PCA and for subtype classification. Results Of seven individuals for whom we have autopsy‐confirmed neuropathology, five had ADNC; one had lobar atrophy and tau pathology in a cortico‐basal degeneration (CBD) distribution; and one had Frontotemporal Lobar Degeneration TDP43 Type A ( GRN mutation). 22 patients had biomarkers consistent with ADNC (17 with elevated PiB PET imaging signal, 5 with AD‐like CSF ). Mean NAR domain scores (impairment level ratings: 0=Normal, .5=questionable/very mild, 1=mild, 2= moderate, 3=severe) revealed relatively normal Attention/Processing Speed (0.2); mildly impaired Executive Function (0.8) and Memory (1.1); questionably/very mildly impaired Language (0.5); and moderately impaired Visuospatial Function (2). Conclusion The MGH PCA program has a robust cohort of patients with a comprehensive data set that includes standardized characterization of the PCA neurocognitive and neurologic profiles, high‐resolution MRI (structural, functional), multimodal PET imaging, CSF biomarkers, and in some cases neuropathology. This data set will allow for detailed examination and improved understanding of this atypical neurodegenerative syndrome. Additional analyses are ongoing, including tau imaging profiles." @default.
• W3111964498 created "2020-12-21" @default.
• W3111964498 creator A5005004760 @default.
• W3111964498 creator A5043800595 @default.
• W3111964498 creator A5045411596 @default.
• W3111964498 creator A5046430509 @default.
• W3111964498 creator A5052275856 @default.
• W3111964498 creator A5055032807 @default.
• W3111964498 creator A5070702967 @default.
• W3111964498 creator A5071093263 @default.
• W3111964498 creator A5081645261 @default.
• W3111964498 creator A5084997308 @default.
• W3111964498 creator A5090611252 @default.
• W3111964498 date "2020-12-01" @default.
• W3111964498 modified "2023-10-18" @default.
• W3111964498 title "Neuropsychological, clinico‐pathologic, neuroimaging, and biomarker profiles of the MGH FTD Unit posterior cortical atrophy (PCA) cohort" @default.
• W3111964498 doi "https://doi.org/10.1002/alz.046126" @default.
• W3111964498 hasPublicationYear "2020" @default.
• W3111964498 type Work @default.
• W3111964498 sameAs 3111964498 @default.
• W3111964498 citedByCount "0" @default.
• W3111964498 crossrefType "journal-article" @default.
• W3111964498 hasAuthorship W3111964498A5005004760 @default.
• W3111964498 hasAuthorship W3111964498A5043800595 @default.
• W3111964498 hasAuthorship W3111964498A5045411596 @default.
• W3111964498 hasAuthorship W3111964498A5046430509 @default.
• W3111964498 hasAuthorship W3111964498A5052275856 @default.
• W3111964498 hasAuthorship W3111964498A5055032807 @default.
• W3111964498 hasAuthorship W3111964498A5070702967 @default.
• W3111964498 hasAuthorship W3111964498A5071093263 @default.
• W3111964498 hasAuthorship W3111964498A5081645261 @default.
• W3111964498 hasAuthorship W3111964498A5084997308 @default.
• W3111964498 hasAuthorship W3111964498A5090611252 @default.
• W3111964498 hasBestOaLocation W31119644981 @default.
• W3111964498 hasConcept C14216870 @default.
• W3111964498 hasConcept C142724271 @default.
• W3111964498 hasConcept C15744967 @default.
• W3111964498 hasConcept C169760540 @default.
• W3111964498 hasConcept C169900460 @default.
• W3111964498 hasConcept C185592680 @default.
• W3111964498 hasConcept C2776228812 @default.
• W3111964498 hasConcept C2776632958 @default.
• W3111964498 hasConcept C2776939681 @default.
• W3111964498 hasConcept C2778641062 @default.
• W3111964498 hasConcept C2779134260 @default.
• W3111964498 hasConcept C2779483572 @default.
• W3111964498 hasConcept C2780130745 @default.
• W3111964498 hasConcept C2781172350 @default.
• W3111964498 hasConcept C2781197716 @default.
• W3111964498 hasConcept C2908647359 @default.
• W3111964498 hasConcept C55493867 @default.
• W3111964498 hasConcept C58693492 @default.
• W3111964498 hasConcept C71924100 @default.
• W3111964498 hasConcept C72563966 @default.
• W3111964498 hasConcept C99454951 @default.
• W3111964498 hasConceptScore W3111964498C14216870 @default.
• W3111964498 hasConceptScore W3111964498C142724271 @default.
• W3111964498 hasConceptScore W3111964498C15744967 @default.
• W3111964498 hasConceptScore W3111964498C169760540 @default.
• W3111964498 hasConceptScore W3111964498C169900460 @default.
• W3111964498 hasConceptScore W3111964498C185592680 @default.
• W3111964498 hasConceptScore W3111964498C2776228812 @default.
• W3111964498 hasConceptScore W3111964498C2776632958 @default.
• W3111964498 hasConceptScore W3111964498C2776939681 @default.
• W3111964498 hasConceptScore W3111964498C2778641062 @default.
• W3111964498 hasConceptScore W3111964498C2779134260 @default.
• W3111964498 hasConceptScore W3111964498C2779483572 @default.
• W3111964498 hasConceptScore W3111964498C2780130745 @default.
• W3111964498 hasConceptScore W3111964498C2781172350 @default.
• W3111964498 hasConceptScore W3111964498C2781197716 @default.
• W3111964498 hasConceptScore W3111964498C2908647359 @default.
• W3111964498 hasConceptScore W3111964498C55493867 @default.
• W3111964498 hasConceptScore W3111964498C58693492 @default.
• W3111964498 hasConceptScore W3111964498C71924100 @default.
• W3111964498 hasConceptScore W3111964498C72563966 @default.
• W3111964498 hasConceptScore W3111964498C99454951 @default.
• W3111964498 hasIssue "S6" @default.
• W3111964498 hasLocation W31119644981 @default.
• W3111964498 hasOpenAccess W3111964498 @default.
• W3111964498 hasPrimaryLocation W31119644981 @default.
• W3111964498 hasRelatedWork W1508993384 @default.
• W3111964498 hasRelatedWork W2000419411 @default.
• W3111964498 hasRelatedWork W2093041092 @default.
• W3111964498 hasRelatedWork W2128474176 @default.
• W3111964498 hasRelatedWork W2738690256 @default.
• W3111964498 hasRelatedWork W2781541284 @default.
• W3111964498 hasRelatedWork W2783448660 @default.
• W3111964498 hasRelatedWork W3200820683 @default.
• W3111964498 hasRelatedWork W4233463301 @default.
• W3111964498 hasRelatedWork W4324311057 @default.
• W3111964498 hasVolume "16" @default.
• W3111964498 isParatext "false" @default.
• W3111964498 isRetracted "false" @default.
• W3111964498 magId "3111964498" @default.
• W3111964498 workType "article" @default.