Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111972783> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W3111972783 abstract "Developmental BiologyDuring embryonic development, blood stem cells are derived from vascular endothelial cells that line the walls of developing arteries. The transition from endothelial cells to blood stem cells is highly regulated and restricted to a small portion of endothelial cells during a brief period of time. The mechanisms regulating this transition are also poorly understood. Kasper et al. found that microRNA-223 intrinsically restrains the vascular hematopoietic transition by regulating N-glycan biosynthesis to restrict hematopoietic stem and progenitor cell production and differentiation. Genetics or chemicals could be used to alter the sugar code and change the efficiency of blood production in embryos. Thus, genetically or pharmacologically altering N-glycan biosynthesis in endothelial cells could improve the efficiency of the production of blood stem cells, which could then be used to treat blood diseases such as leukemia.Science , this issue p. [1186][1] [1]: /lookup/doi/10.1126/science.aaz2121" @default.
- W3111972783 created "2020-12-21" @default.
- W3111972783 creator A5090113642 @default.
- W3111972783 date "2020-12-03" @default.
- W3111972783 modified "2023-09-26" @default.
- W3111972783 title "Sugar code regulates blood stem cells" @default.
- W3111972783 doi "https://doi.org/10.1126/science.370.6521.1177-b" @default.
- W3111972783 hasPublicationYear "2020" @default.
- W3111972783 type Work @default.
- W3111972783 sameAs 3111972783 @default.
- W3111972783 citedByCount "0" @default.
- W3111972783 crossrefType "journal-article" @default.
- W3111972783 hasAuthorship W3111972783A5090113642 @default.
- W3111972783 hasConcept C10205521 @default.
- W3111972783 hasConcept C104317684 @default.
- W3111972783 hasConcept C109159458 @default.
- W3111972783 hasConcept C123012128 @default.
- W3111972783 hasConcept C145103041 @default.
- W3111972783 hasConcept C201750760 @default.
- W3111972783 hasConcept C202751555 @default.
- W3111972783 hasConcept C2778086970 @default.
- W3111972783 hasConcept C28328180 @default.
- W3111972783 hasConcept C54355233 @default.
- W3111972783 hasConcept C60781801 @default.
- W3111972783 hasConcept C86803240 @default.
- W3111972783 hasConcept C95444343 @default.
- W3111972783 hasConceptScore W3111972783C10205521 @default.
- W3111972783 hasConceptScore W3111972783C104317684 @default.
- W3111972783 hasConceptScore W3111972783C109159458 @default.
- W3111972783 hasConceptScore W3111972783C123012128 @default.
- W3111972783 hasConceptScore W3111972783C145103041 @default.
- W3111972783 hasConceptScore W3111972783C201750760 @default.
- W3111972783 hasConceptScore W3111972783C202751555 @default.
- W3111972783 hasConceptScore W3111972783C2778086970 @default.
- W3111972783 hasConceptScore W3111972783C28328180 @default.
- W3111972783 hasConceptScore W3111972783C54355233 @default.
- W3111972783 hasConceptScore W3111972783C60781801 @default.
- W3111972783 hasConceptScore W3111972783C86803240 @default.
- W3111972783 hasConceptScore W3111972783C95444343 @default.
- W3111972783 hasLocation W31119727831 @default.
- W3111972783 hasOpenAccess W3111972783 @default.
- W3111972783 hasPrimaryLocation W31119727831 @default.
- W3111972783 hasRelatedWork W13336641 @default.
- W3111972783 hasRelatedWork W33726984 @default.
- W3111972783 hasRelatedWork W34415389 @default.
- W3111972783 hasRelatedWork W34901204 @default.
- W3111972783 hasRelatedWork W36821900 @default.
- W3111972783 hasRelatedWork W38135774 @default.
- W3111972783 hasRelatedWork W6294511 @default.
- W3111972783 hasRelatedWork W6595454 @default.
- W3111972783 hasRelatedWork W8963448 @default.
- W3111972783 hasRelatedWork W1837291 @default.
- W3111972783 isParatext "false" @default.
- W3111972783 isRetracted "false" @default.
- W3111972783 magId "3111972783" @default.
- W3111972783 workType "article" @default.