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- W3112019588 abstract "Post-translational modifications of proteins are well-established participants in DNA damage response (DDR) pathways, which function in the maintenance of genome integrity. Emerging evidence is starting to reveal the involvement of modifications on RNA in the DDR. RNA modifications are known regulators of gene expression but how and if they participate in DNA repair and genome maintenance has been poorly understood. Here, we review several studies that have now established RNA modifications as key components of DNA damage responses. RNA modifying enzymes and the binding proteins that recognize these modifications localize to and participate in the repair of UV-induced and DNA double-strand break lesions. RNA modifications have a profound effect on DNA-RNA hybrids (R-loops) at DNA damage sites, a structure known to be involved in DNA repair and genome stability. Given the importance of the DDR in suppressing mutations and human diseases such as neurodegeneration, immunodeficiencies, cancer and aging, RNA modification pathways may be involved in human diseases not solely through their roles in gene expression but also by their ability to impact DNA repair and genome stability." @default.
- W3112019588 created "2020-12-21" @default.
- W3112019588 creator A5009031239 @default.
- W3112019588 creator A5061589901 @default.
- W3112019588 creator A5089103469 @default.
- W3112019588 date "2020-12-07" @default.
- W3112019588 modified "2023-10-06" @default.
- W3112019588 title "Emerging roles of RNA modifications in genome integrity" @default.
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- W3112019588 doi "https://doi.org/10.1093/bfgp/elaa022" @default.
- W3112019588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8008162" @default.
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- W3112019588 hasPublicationYear "2020" @default.
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