FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3112098215> ?p ?o ?g. }

• W3112098215 endingPage "1122" @default.
• W3112098215 startingPage "1111" @default.
• W3112098215 abstract "The Brg/Brahma-associated factor (BAF, mSWI/SNF) chromatin remodeling complex is of importance in development and has been linked to prostate oncogenesis. The oncogenic MUC1-C protein promotes lineage plasticity in the progression of neuroendocrine prostate cancer (NEPC), however, there is no known association between MUC1-C and BAF. We report here that MUC1-C binds directly to the E2F1 transcription factor and that the MUC1-C→E2F1 pathway induces expression of embryonic stem cell-specific BAF (esBAF) components BRG1, ARID1A, BAF60a, BAF155, and BAF170 in castrate-resistant prostate cancer (CRPC) and NEPC cells. In concert with this previously unrecognized pathway, MUC1 was associated with increased expression of E2F1 and esBAF components in NEPC tumors as compared with CRPC, supporting involvement of MUC1-C in activating the E2F1→esBAF pathway with progression to NEPC. MUC1-C formed a nuclear complex with BAF and activated cancer stem cell (CSC) gene signatures and the core pluripotency factor gene network. The MUC1-C→E2F1→BAF pathway was necessary for induction of both the NOTCH1 effector of CSC function and the NANOG pluripotency factor, and collectively, this network drove CSC self-renewal. These findings indicate that MUC1-C promotes NEPC progression by integrating activation of E2F1 and esBAF with induction of NOTCH1, NANOG, and stemness. SIGNIFICANCE: These findings show that MUC1-C, which promotes prostate cancer progression, activates a novel pathway that drives the BAF remodeling complex, induces NOTCH1 and NANOG, and promotes self-renewal of prostate cancer stem cells." @default.
• W3112098215 created "2020-12-21" @default.
• W3112098215 creator A5000432967 @default.
• W3112098215 creator A5010396290 @default.
• W3112098215 creator A5013660351 @default.
• W3112098215 creator A5014295844 @default.
• W3112098215 creator A5028515700 @default.
• W3112098215 creator A5036087604 @default.
• W3112098215 creator A5037062908 @default.
• W3112098215 creator A5041333444 @default.
• W3112098215 creator A5049901416 @default.
• W3112098215 creator A5067054634 @default.
• W3112098215 creator A5075105508 @default.
• W3112098215 creator A5086644570 @default.
• W3112098215 date "2021-02-15" @default.
• W3112098215 modified "2023-10-16" @default.
• W3112098215 title "MUC1-C Activates the BAF (mSWI/SNF) Complex in Prostate Cancer Stem Cells" @default.
• W3112098215 cites W1874056233 @default.
• W3112098215 cites W1904221680 @default.
• W3112098215 cites W1904460196 @default.
• W3112098215 cites W1956018566 @default.
• W3112098215 cites W1981359686 @default.
• W3112098215 cites W1987346667 @default.
• W3112098215 cites W1988756130 @default.
• W3112098215 cites W2031496441 @default.
• W3112098215 cites W2034451570 @default.
• W3112098215 cites W2063851753 @default.
• W3112098215 cites W2066250353 @default.
• W3112098215 cites W2073759231 @default.
• W3112098215 cites W2084888861 @default.
• W3112098215 cites W2114857075 @default.
• W3112098215 cites W2127311430 @default.
• W3112098215 cites W2146426819 @default.
• W3112098215 cites W2159033333 @default.
• W3112098215 cites W2161347865 @default.
• W3112098215 cites W2162760756 @default.
• W3112098215 cites W2168121702 @default.
• W3112098215 cites W2294437982 @default.
• W3112098215 cites W2460529418 @default.
• W3112098215 cites W2525623480 @default.
• W3112098215 cites W2551391139 @default.
• W3112098215 cites W2557697459 @default.
• W3112098215 cites W2563878885 @default.
• W3112098215 cites W2566901884 @default.
• W3112098215 cites W2584632839 @default.
• W3112098215 cites W2595380755 @default.
• W3112098215 cites W2604994143 @default.
• W3112098215 cites W2606450485 @default.
• W3112098215 cites W2611960761 @default.
• W3112098215 cites W2614778484 @default.
• W3112098215 cites W2739961143 @default.
• W3112098215 cites W2760742318 @default.
• W3112098215 cites W2790601065 @default.
• W3112098215 cites W2805888211 @default.
• W3112098215 cites W2810613916 @default.
• W3112098215 cites W2885945442 @default.
• W3112098215 cites W2902716564 @default.
• W3112098215 cites W2939356024 @default.
• W3112098215 cites W2942592603 @default.
• W3112098215 cites W2946421021 @default.
• W3112098215 cites W2973164205 @default.
• W3112098215 cites W2999646405 @default.
• W3112098215 cites W3004733773 @default.
• W3112098215 cites W3010398944 @default.
• W3112098215 cites W3028394313 @default.
• W3112098215 cites W3036121967 @default.
• W3112098215 cites W3044350289 @default.
• W3112098215 doi "https://doi.org/10.1158/0008-5472.can-20-2588" @default.
• W3112098215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8026569" @default.
• W3112098215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33323379" @default.
• W3112098215 hasPublicationYear "2021" @default.
• W3112098215 type Work @default.
• W3112098215 sameAs 3112098215 @default.
• W3112098215 citedByCount "38" @default.
• W3112098215 countsByYear W31120982152021 @default.
• W3112098215 countsByYear W31120982152022 @default.
• W3112098215 countsByYear W31120982152023 @default.
• W3112098215 crossrefType "journal-article" @default.
• W3112098215 hasAuthorship W3112098215A5000432967 @default.
• W3112098215 hasAuthorship W3112098215A5010396290 @default.
• W3112098215 hasAuthorship W3112098215A5013660351 @default.
• W3112098215 hasAuthorship W3112098215A5014295844 @default.
• W3112098215 hasAuthorship W3112098215A5028515700 @default.
• W3112098215 hasAuthorship W3112098215A5036087604 @default.
• W3112098215 hasAuthorship W3112098215A5037062908 @default.
• W3112098215 hasAuthorship W3112098215A5041333444 @default.
• W3112098215 hasAuthorship W3112098215A5049901416 @default.
• W3112098215 hasAuthorship W3112098215A5067054634 @default.
• W3112098215 hasAuthorship W3112098215A5075105508 @default.
• W3112098215 hasAuthorship W3112098215A5086644570 @default.
• W3112098215 hasBestOaLocation W31120982151 @default.
• W3112098215 hasConcept C104317684 @default.
• W3112098215 hasConcept C107459253 @default.
• W3112098215 hasConcept C121608353 @default.
• W3112098215 hasConcept C145103041 @default.
• W3112098215 hasConcept C207701140 @default.
• W3112098215 hasConcept C2779723316 @default.
• W3112098215 hasConcept C2780192828 @default.

• next