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- W3112103485 endingPage "3743" @default.
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- W3112103485 abstract "Patient survival from head and neck squamous cell carcinoma (HNSCC), the seventh most common cause of cancer, has not markedly improved in recent years despite the approval of targeted therapies and immunotherapy agents. Precision medicine approaches that seek to individualise therapy through the use of predictive biomarkers and stratification strategies offer opportunities to improve therapeutic success in HNSCC. To enable precision medicine of HNSCC, an understanding of the microenvironment that influences tumour growth and response to therapy is required alongside research tools that recapitulate the features of human tumours. In this review, we highlight the importance of the tumour microenvironment in HNSCC, with a focus on tumour hypoxia, and discuss the fidelity of patient-derived xenograft and organoids for modelling human HNSCC and response to therapy. We describe the benefits of patient-derived models over alternative preclinical models and their limitations in clinical relevance and how these impact their utility in precision medicine in HNSCC for the discovery of new therapeutic agents, as well as predictive biomarkers to identify patients’ most likely to respond to therapy." @default.
- W3112103485 created "2020-12-21" @default.
- W3112103485 creator A5017084585 @default.
- W3112103485 creator A5021180262 @default.
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- W3112103485 creator A5064223143 @default.
- W3112103485 creator A5065301832 @default.
- W3112103485 creator A5067234230 @default.
- W3112103485 creator A5078146193 @default.
- W3112103485 date "2020-12-12" @default.
- W3112103485 modified "2023-10-18" @default.
- W3112103485 title "Patient-Derived Xenograft and Organoid Models for Precision Medicine Targeting of the Tumour Microenvironment in Head and Neck Cancer" @default.
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