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- W3112156986 abstract "Abstract Genomic amplification of the distal portion of chromosome 3q, which encodes a number of oncogenic proteins, is one of the most frequent chromosomal abnormalities in malignancy. Here we functionally characterise a non-protein product of the 3q region, the long noncoding RNA (lncRNA) PLANE, which is upregulated in diverse cancer types through copy number gain as well as E2F1-mediated transcriptional activation. PLANE forms an RNA-RNA duplex with the nuclear receptor co-repressor 2 (NCOR2) pre-mRNA at intron 45, binds to heterogeneous ribonucleoprotein M (hnRNPM) and facilitates the association of hnRNPM with the intron, thus leading to repression of the alternative splicing (AS) event generating NCOR2-202, a major protein-coding NCOR2 AS variant. This is, at least in part, responsible for PLANE-mediated promotion of cancer cell proliferation and tumorigenicity. These results uncover the function and regulation of PLANE and suggest that PLANE may constitute a therapeutic target in the pan-cancer context." @default.
- W3112156986 created "2020-12-21" @default.
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- W3112156986 date "2021-06-18" @default.
- W3112156986 modified "2023-10-17" @default.
- W3112156986 title "The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis" @default.
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- W3112156986 doi "https://doi.org/10.1038/s41467-021-24099-4" @default.
- W3112156986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8213729" @default.
- W3112156986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34145290" @default.
- W3112156986 hasPublicationYear "2021" @default.
- W3112156986 type Work @default.