FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3112158950> ?p ?o ?g. }

• W3112158950 endingPage "1050" @default.
• W3112158950 startingPage "1050" @default.
• W3112158950 abstract "Piscine orthoreovirus 1 (PRV-1) is the causative agent of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar). The virus is widespread in Atlantic salmon and was present in Norway long before the first description of HSMI in 1999. Furthermore, in Canada the virus is prevalent in farmed Atlantic salmon but HSMI is not and Canadian isolates have failed to reproduce HSMI experimentally. This has led to the hypothesis that there are virulence differences between PRV-1 isolates. In this study we performed a dose standardized challenge trial, comparing six PRV-1 isolates, including two Norwegian field isolates from 2018, three historical Norwegian isolates predating the first report of HSMI and one Canadian isolate. The Norwegian 2018 isolates induced lower viral protein load in blood cells but higher plasma viremia. Following peak replication in blood, the two Norwegian 2018 isolates induced histopathological lesions in the heart consistent with HSMI, whereas all three historical Norwegian and the Canadian isolates induced only mild cardiac lesions. This is the first demonstration of virulence differences between PRV-1 isolates and the phenotypic differences are linked to viral proteins encoded by segment S1, M2, L1, L2 and S4." @default.
• W3112158950 created "2020-12-21" @default.
• W3112158950 creator A5012877296 @default.
• W3112158950 creator A5016833963 @default.
• W3112158950 creator A5023888469 @default.
• W3112158950 creator A5024610458 @default.
• W3112158950 creator A5024656049 @default.
• W3112158950 creator A5027164670 @default.
• W3112158950 creator A5043187304 @default.
• W3112158950 creator A5043645280 @default.
• W3112158950 creator A5050605855 @default.
• W3112158950 creator A5054377223 @default.
• W3112158950 creator A5057304546 @default.
• W3112158950 creator A5058760737 @default.
• W3112158950 creator A5070654365 @default.
• W3112158950 creator A5072439769 @default.
• W3112158950 creator A5085615393 @default.
• W3112158950 creator A5086295782 @default.
• W3112158950 date "2020-12-14" @default.
• W3112158950 modified "2023-10-16" @default.
• W3112158950 title "Piscine Orthoreovirus-1 Isolates Differ in Their Ability to Induce Heart and Skeletal Muscle Inflammation in Atlantic Salmon (Salmo salar)" @default.
• W3112158950 cites W1902783325 @default.
• W3112158950 cites W2000775429 @default.
• W3112158950 cites W2028824635 @default.
• W3112158950 cites W2044444467 @default.
• W3112158950 cites W2060316055 @default.
• W3112158950 cites W2097369137 @default.
• W3112158950 cites W2102882830 @default.
• W3112158950 cites W2108983368 @default.
• W3112158950 cites W2120960176 @default.
• W3112158950 cites W2122170158 @default.
• W3112158950 cites W2127086515 @default.
• W3112158950 cites W2132926880 @default.
• W3112158950 cites W2145480407 @default.
• W3112158950 cites W2153559406 @default.
• W3112158950 cites W2158062405 @default.
• W3112158950 cites W2158468200 @default.
• W3112158950 cites W2166504915 @default.
• W3112158950 cites W2232595415 @default.
• W3112158950 cites W2400682207 @default.
• W3112158950 cites W2408328645 @default.
• W3112158950 cites W2438042720 @default.
• W3112158950 cites W2589730151 @default.
• W3112158950 cites W2598770484 @default.
• W3112158950 cites W2745631600 @default.
• W3112158950 cites W2795919221 @default.
• W3112158950 cites W2799524357 @default.
• W3112158950 cites W2809158067 @default.
• W3112158950 cites W2921068751 @default.
• W3112158950 cites W2945877197 @default.
• W3112158950 cites W2950758399 @default.
• W3112158950 cites W2951086303 @default.
• W3112158950 cites W2971809307 @default.
• W3112158950 cites W3008459698 @default.
• W3112158950 cites W3022327832 @default.
• W3112158950 cites W3104784311 @default.
• W3112158950 cites W3173832084 @default.
• W3112158950 cites W4231784440 @default.
• W3112158950 cites W4362073016 @default.
• W3112158950 cites W568682068 @default.
• W3112158950 doi "https://doi.org/10.3390/pathogens9121050" @default.
• W3112158950 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7765100" @default.
• W3112158950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33327651" @default.
• W3112158950 hasPublicationYear "2020" @default.
• W3112158950 type Work @default.
• W3112158950 sameAs 3112158950 @default.
• W3112158950 citedByCount "26" @default.
• W3112158950 countsByYear W31121589502021 @default.
• W3112158950 countsByYear W31121589502022 @default.
• W3112158950 countsByYear W31121589502023 @default.
• W3112158950 crossrefType "journal-article" @default.
• W3112158950 hasAuthorship W3112158950A5012877296 @default.
• W3112158950 hasAuthorship W3112158950A5016833963 @default.
• W3112158950 hasAuthorship W3112158950A5023888469 @default.
• W3112158950 hasAuthorship W3112158950A5024610458 @default.
• W3112158950 hasAuthorship W3112158950A5024656049 @default.
• W3112158950 hasAuthorship W3112158950A5027164670 @default.
• W3112158950 hasAuthorship W3112158950A5043187304 @default.
• W3112158950 hasAuthorship W3112158950A5043645280 @default.
• W3112158950 hasAuthorship W3112158950A5050605855 @default.
• W3112158950 hasAuthorship W3112158950A5054377223 @default.
• W3112158950 hasAuthorship W3112158950A5057304546 @default.
• W3112158950 hasAuthorship W3112158950A5058760737 @default.
• W3112158950 hasAuthorship W3112158950A5070654365 @default.
• W3112158950 hasAuthorship W3112158950A5072439769 @default.
• W3112158950 hasAuthorship W3112158950A5085615393 @default.
• W3112158950 hasAuthorship W3112158950A5086295782 @default.
• W3112158950 hasBestOaLocation W31121589501 @default.
• W3112158950 hasConcept C104317684 @default.
• W3112158950 hasConcept C138885662 @default.
• W3112158950 hasConcept C142462285 @default.
• W3112158950 hasConcept C159047783 @default.
• W3112158950 hasConcept C2522874641 @default.
• W3112158950 hasConcept C2776185481 @default.
• W3112158950 hasConcept C2777940460 @default.
• W3112158950 hasConcept C2909208804 @default.
• W3112158950 hasConcept C41895202 @default.
• W3112158950 hasConcept C505870484 @default.

• next