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- W3112177931 abstract "Abstract High-throughput screening of chemical libraries is traditionally utilized to identify potential drug candidates. A time-saving alternative to this resource-intensive process is to find new uses for existing drugs. The development of Nuedexta, a combination of dextromethorphan and quinidine, is an early example of this strategy. What initially began as a search for a drug that would inhibit excitotoxicity, thought to be an etiologic factor in stroke and neurodegenerative diseases, ultimately proved to be a potent symptomatic treatment for amyotrophic lateral sclerosis and kindred disorders. The basis for these unexpected results have led to renewed interest in the development of pharmacologic agents that target sigma receptors which preferentially decorate neurons in the brainstem and cerebellum. The story of Nuedexta, detailed herein, is a blueprint for drug discovery, complete with moments of inspiration and persistence in the face of doubt." @default.
- W3112177931 created "2020-12-21" @default.
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- W3112177931 creator A5065531439 @default.
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- W3112177931 date "2021-01-01" @default.
- W3112177931 modified "2023-10-17" @default.
- W3112177931 title "Repurposing FDA-approved pharmaceuticals: The development of Nuedexta" @default.
- W3112177931 doi "https://doi.org/10.1016/b978-0-12-816475-4.00001-x" @default.
- W3112177931 hasPublicationYear "2021" @default.
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