FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3112180663> ?p ?o ?g. }

• W3112180663 abstract "The present study reveals a link between protein arginine methyltransferase 5 (PRMT5) and Homebox A9 (HoxA9) in the regulation of cardiomyocyte hypertrophy. In cardiomyocyte hypertrophy induced by β-adrenergic receptor agonist isoprenaline (ISO), PRMT5 expression was decreased while HoxA9 was upregulated. Silencing of PRMT5 or inhibition of PRMT5 by its pharmacological inhibitor EPZ augmented the expressions of cardiomyocyte hypertrophic genes brain natriuretic peptide (BNP) and β-Myosin Heavy Chain (β-MHC), whereas overexpression of PRMT5 inhibited ISO-induced cardiomyocyte hypertrophy, suggesting that PRMT5 ameliorates cardiomyocyte hypertrophy. On the contrary, HoxA9 promoted cardiomyocyte hypertrophy, as implied by the gain-of-function and loss-of-function experiments. HoxA9 was involved in the regulation of PRMT5 in cardiomyocyte hypertrophy, since HoxA9 knockdown prevented si-RPMT5-induced cardiomyocyte hypertrophy, and HoxA9 expression impaired the anti-hypertrophic effect of PRMT5. Co-immunoprecipitation experiments revealed that there were physical interactions between PRMT5 and HoxA9. The symmetric dimethylation level of HoxA9 was decreased by ISO or EPZ treatment, suggesting that HoxA9 is methylated by PRMT5. Additionally, PRMT5 repressed the expression of HoxA9. Chromatin immunoprecipitation (ChIP) assay demonstrated that HoxA9 could bind to the promoter of BNP, and that this binding affinity was further enhanced by ISO or EPZ. In conclusion, this study suggests that PRMT5 symmetric dimethylates HoxA9 and represses HoxA9 expression, thus impairing its binding to BNP promoter and ultimately protecting against cardiomyocyte hypertrophy. These findings provide a novel insight of the mechanism underlying the cardiac protective effect of PRMT5, and suggest potential therapeutic strategies of PRMT5 activation or HoxA9 inhibition in treatment of cardiac hypertrophy." @default.
• W3112180663 created "2020-12-21" @default.
• W3112180663 creator A5009067006 @default.
• W3112180663 creator A5018636031 @default.
• W3112180663 creator A5025284558 @default.
• W3112180663 creator A5026035950 @default.
• W3112180663 creator A5030900462 @default.
• W3112180663 creator A5036647389 @default.
• W3112180663 creator A5038096051 @default.
• W3112180663 creator A5046852793 @default.
• W3112180663 creator A5052398666 @default.
• W3112180663 date "2020-12-10" @default.
• W3112180663 modified "2023-10-16" @default.
• W3112180663 title "PRMT5 Prevents Cardiomyocyte Hypertrophy via Symmetric Dimethylating HoxA9 and Repressing HoxA9 Expression" @default.
• W3112180663 cites W123990481 @default.
• W3112180663 cites W1965642212 @default.
• W3112180663 cites W1969814510 @default.
• W3112180663 cites W1977303730 @default.
• W3112180663 cites W1999112642 @default.
• W3112180663 cites W2001628772 @default.
• W3112180663 cites W2005490820 @default.
• W3112180663 cites W2010144072 @default.
• W3112180663 cites W2023106521 @default.
• W3112180663 cites W2043308559 @default.
• W3112180663 cites W2045575123 @default.
• W3112180663 cites W2066050590 @default.
• W3112180663 cites W2071100278 @default.
• W3112180663 cites W2071576183 @default.
• W3112180663 cites W2072932481 @default.
• W3112180663 cites W2079360110 @default.
• W3112180663 cites W2105352992 @default.
• W3112180663 cites W2126390962 @default.
• W3112180663 cites W2129622967 @default.
• W3112180663 cites W2148608806 @default.
• W3112180663 cites W2157136664 @default.
• W3112180663 cites W2163388642 @default.
• W3112180663 cites W2167407855 @default.
• W3112180663 cites W2223221956 @default.
• W3112180663 cites W2262980944 @default.
• W3112180663 cites W2292835399 @default.
• W3112180663 cites W2319516509 @default.
• W3112180663 cites W241169641 @default.
• W3112180663 cites W2570732803 @default.
• W3112180663 cites W2600613437 @default.
• W3112180663 cites W2612047332 @default.
• W3112180663 cites W2789601239 @default.
• W3112180663 cites W2790014662 @default.
• W3112180663 cites W2808913983 @default.
• W3112180663 cites W2902088101 @default.
• W3112180663 cites W2904687091 @default.
• W3112180663 cites W2911429177 @default.
• W3112180663 cites W2912677857 @default.
• W3112180663 cites W2955103159 @default.
• W3112180663 cites W2995980699 @default.
• W3112180663 cites W3046274917 @default.
• W3112180663 cites W4292400027 @default.
• W3112180663 cites W76215130 @default.
• W3112180663 doi "https://doi.org/10.3389/fphar.2020.600627" @default.
• W3112180663 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7793800" @default.
• W3112180663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33424610" @default.
• W3112180663 hasPublicationYear "2020" @default.
• W3112180663 type Work @default.
• W3112180663 sameAs 3112180663 @default.
• W3112180663 citedByCount "6" @default.
• W3112180663 countsByYear W31121806632021 @default.
• W3112180663 countsByYear W31121806632022 @default.
• W3112180663 countsByYear W31121806632023 @default.
• W3112180663 crossrefType "journal-article" @default.
• W3112180663 hasAuthorship W3112180663A5009067006 @default.
• W3112180663 hasAuthorship W3112180663A5018636031 @default.
• W3112180663 hasAuthorship W3112180663A5025284558 @default.
• W3112180663 hasAuthorship W3112180663A5026035950 @default.
• W3112180663 hasAuthorship W3112180663A5030900462 @default.
• W3112180663 hasAuthorship W3112180663A5036647389 @default.
• W3112180663 hasAuthorship W3112180663A5038096051 @default.
• W3112180663 hasAuthorship W3112180663A5046852793 @default.
• W3112180663 hasAuthorship W3112180663A5052398666 @default.
• W3112180663 hasBestOaLocation W31121806631 @default.
• W3112180663 hasConcept C101762097 @default.
• W3112180663 hasConcept C104317684 @default.
• W3112180663 hasConcept C111819275 @default.
• W3112180663 hasConcept C119056186 @default.
• W3112180663 hasConcept C126322002 @default.
• W3112180663 hasConcept C127561419 @default.
• W3112180663 hasConcept C134018914 @default.
• W3112180663 hasConcept C134320426 @default.
• W3112180663 hasConcept C150194340 @default.
• W3112180663 hasConcept C167414201 @default.
• W3112180663 hasConcept C173396325 @default.
• W3112180663 hasConcept C185592680 @default.
• W3112180663 hasConcept C33288867 @default.
• W3112180663 hasConcept C502942594 @default.
• W3112180663 hasConcept C55493867 @default.
• W3112180663 hasConcept C71924100 @default.
• W3112180663 hasConcept C86803240 @default.
• W3112180663 hasConcept C91965660 @default.
• W3112180663 hasConcept C95444343 @default.
• W3112180663 hasConceptScore W3112180663C101762097 @default.
• W3112180663 hasConceptScore W3112180663C104317684 @default.
• W3112180663 hasConceptScore W3112180663C111819275 @default.

• next