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• W3112181343 abstract "Vogt-Koyanagi-Harada (VKH) syndrome is a systemic autoimmune disorder that targets tissues containing melanocytes such as the eye, inner ear, meninges and skin. Despite a common genetic susceptibility, the association between VKH syndrome and rheumatoid arthritis (RA) has been rarely reported. To report a rare case with RA who developed incomplete VKH syndrome. The case is described and a review of the literature on similar cases is presented. A 26 year-old Tunisian woman, with a medical history of Hashimoto’s thyroiditis, was diagnosed on 2011 with seropositive and erosive RA treated with Leflunomide. She presented to the emergency department on June 2018 with bilateral blurred vision associated with photophobia, vomiting and severe headache that had gradually progressed over the preceding five days. Ophthalmological examinations showed typical findings of VKH syndrome. The patient received intravenous infusions of methylprednisolone at a daily dose of 1000 mg for 3 days that was followed orally with 2 mg/kg of prednisone equivalent. Given the lack of improvement in visual acuity after 3 weeks of treatment, azathioprine was added and VKH remission was achieved on September 2018 as confirmed on optical coherence tomography. However, the patient passed away on October 2018 due to infectious complications of the immunosuppressant agents. Treatments and outcomes of VKH are variable. Pharmacological management of such an association between RA and VKH may be challenging, so care must be taken to balance treatment escalation with adverse events in patients at risk." @default.
• W3112181343 created "2020-12-21" @default.
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• W3112181343 date "2021-01-01" @default.
• W3112181343 modified "2023-10-08" @default.
• W3112181343 title "Rare association between rheumatoid arthritis and Vogt-Koyanagi-Harada syndrome: A case-based review" @default.
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• W3112181343 doi "https://doi.org/10.1016/j.ejr.2020.11.004" @default.
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