FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3112202821> ?p ?o ?g. }

• W3112202821 endingPage "529" @default.
• W3112202821 startingPage "520" @default.
• W3112202821 abstract "Objective Chimeric antigen receptor (CAR)-T cell strategies ideally target a surface antigen that is exclusively and uniformly expressed by tumors; however, no such antigen is known for high-grade serous ovarian carcinoma (HGSC). A potential solution involves combinatorial antigen targeting with AND or OR logic-gating. Therefore, we investigated co-expression of CA125, Mesothelin (MSLN) and Folate Receptor alpha (FOLRA) on individual tumor cells in HGSC. Methods RNA expression of CA125, MSLN, and FOLR1 was assessed using TCGA (HGSC) and GTEx (healthy tissues) databases. Antigen expression profiles and CD3+, CD8+ and CD20+ tumor-infiltrating lymphocyte (TIL) patterns were assessed in primary and recurrent HGSC by multiplex immunofluorescence and immunohistochemistry. Results At the transcriptional level, each antigen was overexpressed in >90% of cases; however, MSLN and FOLR1 showed substantial expression in healthy tissues. At the protein level, CA125 was expressed by the highest proportion of cases and tumor cells per case, followed by MSLN and FOLRA. The most promising pairwise combination was CA125 and/or MSLN (OR gate), with 51.9% of cases containing ≥90% of tumor cells expressing one or both antigens. In contrast, only 5.8% of cases contained ≥90% of tumor cells co-expressing CA125 and MSLN (AND gate). Antigen expression patterns showed modest correlations with TIL. Recurrent tumors retained expression of all three antigens and showed increased TIL densities. Conclusions An OR-gated CAR-T cell strategy against CA125 and MSLN would target the majority of tumor cells in most cases. Antigen expression and T-cell infiltration patterns are favorable for this strategy in primary and recurrent disease." @default.
• W3112202821 created "2020-12-21" @default.
• W3112202821 creator A5000164383 @default.
• W3112202821 creator A5010760123 @default.
• W3112202821 creator A5032131835 @default.
• W3112202821 creator A5047509474 @default.
• W3112202821 creator A5058837420 @default.
• W3112202821 creator A5062939544 @default.
• W3112202821 creator A5063693344 @default.
• W3112202821 creator A5066165449 @default.
• W3112202821 creator A5069976109 @default.
• W3112202821 creator A5080359271 @default.
• W3112202821 creator A5087258737 @default.
• W3112202821 creator A5090290067 @default.
• W3112202821 date "2021-02-01" @default.
• W3112202821 modified "2023-10-01" @default.
• W3112202821 title "Co-expression patterns of chimeric antigen receptor (CAR)-T cell target antigens in primary and recurrent ovarian cancer" @default.
• W3112202821 cites W1974452295 @default.
• W3112202821 cites W2018838463 @default.
• W3112202821 cites W2049490668 @default.
• W3112202821 cites W2060459188 @default.
• W3112202821 cites W2065226341 @default.
• W3112202821 cites W2071661095 @default.
• W3112202821 cites W2080370558 @default.
• W3112202821 cites W2082059231 @default.
• W3112202821 cites W2102596101 @default.
• W3112202821 cites W2120888343 @default.
• W3112202821 cites W2128027405 @default.
• W3112202821 cites W2137074525 @default.
• W3112202821 cites W2138654358 @default.
• W3112202821 cites W2140317464 @default.
• W3112202821 cites W2149992805 @default.
• W3112202821 cites W2168572010 @default.
• W3112202821 cites W2171632125 @default.
• W3112202821 cites W2174659040 @default.
• W3112202821 cites W2428958921 @default.
• W3112202821 cites W2515679040 @default.
• W3112202821 cites W2531335004 @default.
• W3112202821 cites W2552487040 @default.
• W3112202821 cites W2593637805 @default.
• W3112202821 cites W2603744382 @default.
• W3112202821 cites W2607211817 @default.
• W3112202821 cites W2751648491 @default.
• W3112202821 cites W2755040856 @default.
• W3112202821 cites W2800654890 @default.
• W3112202821 cites W2883796806 @default.
• W3112202821 cites W2899700403 @default.
• W3112202821 cites W2902185751 @default.
• W3112202821 cites W2917476978 @default.
• W3112202821 cites W2942929936 @default.
• W3112202821 cites W2945862854 @default.
• W3112202821 cites W2995900562 @default.
• W3112202821 cites W3003859981 @default.
• W3112202821 cites W3016085372 @default.
• W3112202821 cites W3032112713 @default.
• W3112202821 cites W3109929953 @default.
• W3112202821 cites W4235171991 @default.
• W3112202821 doi "https://doi.org/10.1016/j.ygyno.2020.12.005" @default.
• W3112202821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33342620" @default.
• W3112202821 hasPublicationYear "2021" @default.
• W3112202821 type Work @default.
• W3112202821 sameAs 3112202821 @default.
• W3112202821 citedByCount "6" @default.
• W3112202821 countsByYear W31122028212022 @default.
• W3112202821 countsByYear W31122028212023 @default.
• W3112202821 crossrefType "journal-article" @default.
• W3112202821 hasAuthorship W3112202821A5000164383 @default.
• W3112202821 hasAuthorship W3112202821A5010760123 @default.
• W3112202821 hasAuthorship W3112202821A5032131835 @default.
• W3112202821 hasAuthorship W3112202821A5047509474 @default.
• W3112202821 hasAuthorship W3112202821A5058837420 @default.
• W3112202821 hasAuthorship W3112202821A5062939544 @default.
• W3112202821 hasAuthorship W3112202821A5063693344 @default.
• W3112202821 hasAuthorship W3112202821A5066165449 @default.
• W3112202821 hasAuthorship W3112202821A5069976109 @default.
• W3112202821 hasAuthorship W3112202821A5080359271 @default.
• W3112202821 hasAuthorship W3112202821A5087258737 @default.
• W3112202821 hasAuthorship W3112202821A5090290067 @default.
• W3112202821 hasConcept C121608353 @default.
• W3112202821 hasConcept C126322002 @default.
• W3112202821 hasConcept C147483822 @default.
• W3112202821 hasConcept C203014093 @default.
• W3112202821 hasConcept C204232928 @default.
• W3112202821 hasConcept C2776090121 @default.
• W3112202821 hasConcept C2776662205 @default.
• W3112202821 hasConcept C2777045440 @default.
• W3112202821 hasConcept C2777701055 @default.
• W3112202821 hasConcept C2780427987 @default.
• W3112202821 hasConcept C3875195 @default.
• W3112202821 hasConcept C502942594 @default.
• W3112202821 hasConcept C71924100 @default.
• W3112202821 hasConcept C8891405 @default.
• W3112202821 hasConceptScore W3112202821C121608353 @default.
• W3112202821 hasConceptScore W3112202821C126322002 @default.
• W3112202821 hasConceptScore W3112202821C147483822 @default.
• W3112202821 hasConceptScore W3112202821C203014093 @default.
• W3112202821 hasConceptScore W3112202821C204232928 @default.
• W3112202821 hasConceptScore W3112202821C2776090121 @default.

• next