FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3112293468> ?p ?o ?g. }

• W3112293468 endingPage "506" @default.
• W3112293468 startingPage "498" @default.
• W3112293468 abstract "ABSTRACT BACKGROUND: Lubiprostone is a type 2 chloride channel activator that has been shown to be efficacious and safe in the treatment for chronic constipation. OBJECTIVE: To systematically review randomized clinical trials (RCTs) assessing efficacy of lubiprostone for patients with chronic idiopathic constipation (CIC), irritable bowel syndrome with predominant constipation (IBS-C) and opioid-induced constipation (OIC). METHODS: Searches were conducted in PubMed, LILACS, Cochrane Collaboration Database, and Centre for Reviews and Dissemination. Lubiprostone RCTs reporting outcomes of spontaneous bowel movements (SBM) and abdominal pain or discomfort were deemed eligible. Meta-analysis was performed calculating risk ratios and 95% confidence intervals, using the Mantel-Haenszel method and random effects model. RESULTS: Searches yielded 109 records representing 93 non-duplicate publications, and 11 RCTs (978 CIC, 1,366 IBS-C, 1,300 OIC, total = 3,644) met inclusion criteria. Qualitative synthesis showed that for CIC patients, lubiprostone is superior to placebo in terms of SBM outcomes. Meta-analysis for CIC was feasible for full responder and SBM within 24h rates, indicating superiority of lubiprostone over placebo. For IBS-C, lubiprostone was significantly superior for all SBM outcomes in follow-ups ranging from 1 week-3 months. In terms of abdominal pain, lubiprostone provided significantly better symptoms relief, particularly after 1 month of treatment. For OIC, lubiprostone was more effective than placebo for both SBM and discomfort measures. CONCLUSION: Our findings demonstrated that lubiprostone is superior to placebo in terms of SBM frequency for CIC, IBS-C and OIC. In terms of abdominal symptoms, the most pronounced effect was seen for abdominal pain in IBS-C patients." @default.
• W3112293468 created "2020-12-21" @default.
• W3112293468 creator A5002776829 @default.
• W3112293468 creator A5031981085 @default.
• W3112293468 creator A5047009427 @default.
• W3112293468 creator A5066180851 @default.
• W3112293468 date "2020-12-01" @default.
• W3112293468 modified "2023-10-12" @default.
• W3112293468 title "Systematic review with meta-analysis: lubiprostone efficacy on the treatment of patients with constipation" @default.
• W3112293468 cites W1486462492 @default.
• W3112293468 cites W1491518420 @default.
• W3112293468 cites W1511281268 @default.
• W3112293468 cites W1579046272 @default.
• W3112293468 cites W1581601953 @default.
• W3112293468 cites W1688562599 @default.
• W3112293468 cites W1978500749 @default.
• W3112293468 cites W1995874631 @default.
• W3112293468 cites W2001830981 @default.
• W3112293468 cites W2002325903 @default.
• W3112293468 cites W2003147380 @default.
• W3112293468 cites W2009275234 @default.
• W3112293468 cites W2011319006 @default.
• W3112293468 cites W2028706270 @default.
• W3112293468 cites W2040109649 @default.
• W3112293468 cites W2041528960 @default.
• W3112293468 cites W2041581988 @default.
• W3112293468 cites W2041741770 @default.
• W3112293468 cites W2075157391 @default.
• W3112293468 cites W2088344246 @default.
• W3112293468 cites W2098923148 @default.
• W3112293468 cites W2108007239 @default.
• W3112293468 cites W2138706910 @default.
• W3112293468 cites W2165220673 @default.
• W3112293468 cites W2254340343 @default.
• W3112293468 cites W2258033180 @default.
• W3112293468 cites W2301900046 @default.
• W3112293468 cites W2316319365 @default.
• W3112293468 cites W2406639704 @default.
• W3112293468 cites W2525181864 @default.
• W3112293468 cites W2531903751 @default.
• W3112293468 cites W2560141783 @default.
• W3112293468 cites W2569161320 @default.
• W3112293468 cites W2605530173 @default.
• W3112293468 cites W2734740211 @default.
• W3112293468 cites W2748730319 @default.
• W3112293468 cites W2820746895 @default.
• W3112293468 cites W2870333966 @default.
• W3112293468 cites W2907804357 @default.
• W3112293468 cites W2921032209 @default.
• W3112293468 cites W2925328599 @default.
• W3112293468 doi "https://doi.org/10.1590/s0004-2803.202000000-83" @default.
• W3112293468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33331483" @default.
• W3112293468 hasPublicationYear "2020" @default.
• W3112293468 type Work @default.
• W3112293468 sameAs 3112293468 @default.
• W3112293468 citedByCount "4" @default.
• W3112293468 countsByYear W31122934682023 @default.
• W3112293468 crossrefType "journal-article" @default.
• W3112293468 hasAuthorship W3112293468A5002776829 @default.
• W3112293468 hasAuthorship W3112293468A5031981085 @default.
• W3112293468 hasAuthorship W3112293468A5047009427 @default.
• W3112293468 hasAuthorship W3112293468A5066180851 @default.
• W3112293468 hasBestOaLocation W31122934681 @default.
• W3112293468 hasConcept C126322002 @default.
• W3112293468 hasConcept C142724271 @default.
• W3112293468 hasConcept C168563851 @default.
• W3112293468 hasConcept C204787440 @default.
• W3112293468 hasConcept C27081682 @default.
• W3112293468 hasConcept C2778271842 @default.
• W3112293468 hasConcept C2780955771 @default.
• W3112293468 hasConcept C2781093762 @default.
• W3112293468 hasConcept C2781112942 @default.
• W3112293468 hasConcept C3017955636 @default.
• W3112293468 hasConcept C71924100 @default.
• W3112293468 hasConcept C90924648 @default.
• W3112293468 hasConcept C95190672 @default.
• W3112293468 hasConceptScore W3112293468C126322002 @default.
• W3112293468 hasConceptScore W3112293468C142724271 @default.
• W3112293468 hasConceptScore W3112293468C168563851 @default.
• W3112293468 hasConceptScore W3112293468C204787440 @default.
• W3112293468 hasConceptScore W3112293468C27081682 @default.
• W3112293468 hasConceptScore W3112293468C2778271842 @default.
• W3112293468 hasConceptScore W3112293468C2780955771 @default.
• W3112293468 hasConceptScore W3112293468C2781093762 @default.
• W3112293468 hasConceptScore W3112293468C2781112942 @default.
• W3112293468 hasConceptScore W3112293468C3017955636 @default.
• W3112293468 hasConceptScore W3112293468C71924100 @default.
• W3112293468 hasConceptScore W3112293468C90924648 @default.
• W3112293468 hasConceptScore W3112293468C95190672 @default.
• W3112293468 hasIssue "4" @default.
• W3112293468 hasLocation W31122934681 @default.
• W3112293468 hasLocation W31122934682 @default.
• W3112293468 hasOpenAccess W3112293468 @default.
• W3112293468 hasPrimaryLocation W31122934681 @default.
• W3112293468 hasRelatedWork W1989334224 @default.
• W3112293468 hasRelatedWork W2071684431 @default.
• W3112293468 hasRelatedWork W2164738986 @default.
• W3112293468 hasRelatedWork W2329867448 @default.

• next