FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3112293579> ?p ?o ?g. }

• W3112293579 endingPage "781" @default.
• W3112293579 startingPage "773" @default.
• W3112293579 abstract "Abstract Butein is a flavonoid isolated from various medicinal plants. It is known to have different biological activities including anti‐inflammation, anti‐adipogenesis, and anti‐angiogenesis. In the study, we demonstrated the anti‐proliferative effect of butein in human osteosarcoma U‐2 OS cells. Our data showed that butein significantly suppressed the viability and colony formation ability of U‐2 OS cells. Further experiments revealed butein exposure resulted in a cell cycle arrest at S and G2/M phase in U‐2 OS cells. Importantly, we found that butein activated the tumor suppressor p53, and trigged a p53‐dependent senescence in U‐2 OS cells. Knockdown of p53 suppressed the senescence and rescued the viability in butein‐treated U‐2 OS cells. Furthermore, we observed that butein exposure significantly enhanced reactive oxygen species (ROS) levels in U‐2 OS cells. Co‐administration of the ROS inhibitor NAC largely abolished the up‐regulated p53 protein level, and rescued the suppressed viability and colony formation ability in butein‐exposed U‐2 OS cells. Taken together, our data proposed the increased ROS by butein exposure activated p53, and the activated p53 was involved in the anti‐proliferative effect of butein via inducing senescence in U‐2 OS cells. This report suggests that butein is a promising candidate for cancer therapy against osteosarcoma." @default.
• W3112293579 created "2020-12-21" @default.
• W3112293579 creator A5000899886 @default.
• W3112293579 creator A5008144109 @default.
• W3112293579 creator A5008152858 @default.
• W3112293579 creator A5010634285 @default.
• W3112293579 creator A5042717286 @default.
• W3112293579 creator A5050416454 @default.
• W3112293579 creator A5086234259 @default.
• W3112293579 date "2020-12-16" @default.
• W3112293579 modified "2023-10-16" @default.
• W3112293579 title "Butein induces cellular senescence through reactive oxygen species‐mediated p53 activation in osteosarcoma U‐2 <scp>OS</scp> cells" @default.
• W3112293579 cites W1706026279 @default.
• W3112293579 cites W1919662197 @default.
• W3112293579 cites W1969128096 @default.
• W3112293579 cites W1984618218 @default.
• W3112293579 cites W1988325237 @default.
• W3112293579 cites W1990161819 @default.
• W3112293579 cites W1991047372 @default.
• W3112293579 cites W1998104906 @default.
• W3112293579 cites W2002091909 @default.
• W3112293579 cites W2010345740 @default.
• W3112293579 cites W2012821471 @default.
• W3112293579 cites W2014544116 @default.
• W3112293579 cites W2019668164 @default.
• W3112293579 cites W2020177773 @default.
• W3112293579 cites W2023509608 @default.
• W3112293579 cites W2024255564 @default.
• W3112293579 cites W2041831186 @default.
• W3112293579 cites W2046481585 @default.
• W3112293579 cites W2047330128 @default.
• W3112293579 cites W2047887140 @default.
• W3112293579 cites W2051648703 @default.
• W3112293579 cites W2051841827 @default.
• W3112293579 cites W2060113538 @default.
• W3112293579 cites W2065172297 @default.
• W3112293579 cites W2068401819 @default.
• W3112293579 cites W2071113489 @default.
• W3112293579 cites W2080074638 @default.
• W3112293579 cites W2104908670 @default.
• W3112293579 cites W2121241749 @default.
• W3112293579 cites W2130120679 @default.
• W3112293579 cites W2130588960 @default.
• W3112293579 cites W2132834292 @default.
• W3112293579 cites W2157145997 @default.
• W3112293579 cites W2320997035 @default.
• W3112293579 cites W2323314832 @default.
• W3112293579 cites W2606556523 @default.
• W3112293579 cites W2760887818 @default.
• W3112293579 cites W2768672921 @default.
• W3112293579 cites W2790490932 @default.
• W3112293579 cites W2790959029 @default.
• W3112293579 cites W2795993906 @default.
• W3112293579 cites W2799882806 @default.
• W3112293579 cites W2803693522 @default.
• W3112293579 cites W2888447907 @default.
• W3112293579 cites W2891216113 @default.
• W3112293579 cites W2894903471 @default.
• W3112293579 cites W2913817919 @default.
• W3112293579 cites W2953240201 @default.
• W3112293579 cites W2971982660 @default.
• W3112293579 cites W3010819582 @default.
• W3112293579 cites W3016640585 @default.
• W3112293579 cites W3029435888 @default.
• W3112293579 cites W4210433744 @default.
• W3112293579 doi "https://doi.org/10.1002/tox.23079" @default.
• W3112293579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33325610" @default.
• W3112293579 hasPublicationYear "2020" @default.
• W3112293579 type Work @default.
• W3112293579 sameAs 3112293579 @default.
• W3112293579 citedByCount "10" @default.
• W3112293579 countsByYear W31122935792021 @default.
• W3112293579 countsByYear W31122935792022 @default.
• W3112293579 countsByYear W31122935792023 @default.
• W3112293579 crossrefType "journal-article" @default.
• W3112293579 hasAuthorship W3112293579A5000899886 @default.
• W3112293579 hasAuthorship W3112293579A5008144109 @default.
• W3112293579 hasAuthorship W3112293579A5008152858 @default.
• W3112293579 hasAuthorship W3112293579A5010634285 @default.
• W3112293579 hasAuthorship W3112293579A5042717286 @default.
• W3112293579 hasAuthorship W3112293579A5050416454 @default.
• W3112293579 hasAuthorship W3112293579A5086234259 @default.
• W3112293579 hasConcept C1491633281 @default.
• W3112293579 hasConcept C173396325 @default.
• W3112293579 hasConcept C185592680 @default.
• W3112293579 hasConcept C190283241 @default.
• W3112293579 hasConcept C2777760704 @default.
• W3112293579 hasConcept C2780394083 @default.
• W3112293579 hasConcept C48349386 @default.
• W3112293579 hasConcept C502942594 @default.
• W3112293579 hasConcept C522857546 @default.
• W3112293579 hasConcept C53227056 @default.
• W3112293579 hasConcept C55493867 @default.
• W3112293579 hasConcept C86803240 @default.
• W3112293579 hasConcept C95444343 @default.
• W3112293579 hasConceptScore W3112293579C1491633281 @default.
• W3112293579 hasConceptScore W3112293579C173396325 @default.
• W3112293579 hasConceptScore W3112293579C185592680 @default.

• next