FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3112309023> ?p ?o ?g. }

• W3112309023 endingPage "173820" @default.
• W3112309023 startingPage "173820" @default.
• W3112309023 abstract "Of painful conditions, somatic pain of acute nociceptive origin can be effectively managed clinically, while neuropathic pain of chronic neuropathy origin is difficult to control. For molecules involved in pain sensation, substance P (SP) is algesic, exacerbating painful sensation, while its amino-terminal fragment, heptapeptide SP(1-7), confers biological activities different from its full-length parent neuropeptide precursor. We previously demonstrated SP(1-7) interaction with pain processing to alleviate chronic pain. Here we evaluated SP(1-7) and its C-terminal amidated analogue SP(1-7)amide, together with SP and opioid agonist DAMGO. We tested mouse behaviors of both acute somatic pain in tail-flick latency assay, and neuropathic pain in sciatic nerve injury model of chronic constriction injury (CCI). DAMGO produced dose-dependent analgesia for somatic pain as expected, so did both SP(1-7) and its analogue SP(1-7)amide, while SP yielded the opposite effect of algesia, in a phenomenon we termed ‘contrintus’, meaning ‘opposite from within’ to denote that two peptides of the same origin (SP and its metabolic fragment SP(1-7)) produced opposite effects. In CCI model, DAMGO showed a general reduction in allodynia sensitivity for both nerve-injured and normal paws, without selective effect for neuropathic pain, consistent with clinical observation that opioids are less effective for chronic neuropathic pain. On the other hand, both SP(1-7) and SP(1-7)amide displayed dose-dependent anti-allodynia effect that is selective for neuropathic pain. These findings suggest that SP(1-7) and its analogue may be useful for developing pharmaceuticals to treat neuropathic pain." @default.
• W3112309023 created "2020-12-21" @default.
• W3112309023 creator A5011607554 @default.
• W3112309023 creator A5021409111 @default.
• W3112309023 creator A5037716681 @default.
• W3112309023 creator A5037781679 @default.
• W3112309023 creator A5039085563 @default.
• W3112309023 creator A5091135752 @default.
• W3112309023 date "2021-02-01" @default.
• W3112309023 modified "2023-10-14" @default.
• W3112309023 title "The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain" @default.
• W3112309023 cites W1871466956 @default.
• W3112309023 cites W193870025 @default.
• W3112309023 cites W1965538993 @default.
• W3112309023 cites W1971398545 @default.
• W3112309023 cites W1972704245 @default.
• W3112309023 cites W1975585602 @default.
• W3112309023 cites W1979239627 @default.
• W3112309023 cites W1982389161 @default.
• W3112309023 cites W1983871703 @default.
• W3112309023 cites W1985993861 @default.
• W3112309023 cites W1991406619 @default.
• W3112309023 cites W1996418039 @default.
• W3112309023 cites W1999465516 @default.
• W3112309023 cites W2000406331 @default.
• W3112309023 cites W2015377055 @default.
• W3112309023 cites W2016474170 @default.
• W3112309023 cites W2021352491 @default.
• W3112309023 cites W2022008397 @default.
• W3112309023 cites W2024512313 @default.
• W3112309023 cites W2024564120 @default.
• W3112309023 cites W2027914366 @default.
• W3112309023 cites W2034102455 @default.
• W3112309023 cites W2040881037 @default.
• W3112309023 cites W2052512234 @default.
• W3112309023 cites W2058020736 @default.
• W3112309023 cites W2070662386 @default.
• W3112309023 cites W2076029510 @default.
• W3112309023 cites W2089081169 @default.
• W3112309023 cites W2089584103 @default.
• W3112309023 cites W2099854799 @default.
• W3112309023 cites W2099863319 @default.
• W3112309023 cites W2107676335 @default.
• W3112309023 cites W2127894556 @default.
• W3112309023 cites W2132643178 @default.
• W3112309023 cites W2137810479 @default.
• W3112309023 cites W2151402219 @default.
• W3112309023 cites W2153322569 @default.
• W3112309023 cites W2164545627 @default.
• W3112309023 cites W2336936051 @default.
• W3112309023 cites W2442224165 @default.
• W3112309023 cites W2606714802 @default.
• W3112309023 cites W2620872764 @default.
• W3112309023 cites W2749067245 @default.
• W3112309023 cites W2751825693 @default.
• W3112309023 cites W2789922692 @default.
• W3112309023 cites W2801658991 @default.
• W3112309023 cites W2801725617 @default.
• W3112309023 cites W2808652654 @default.
• W3112309023 cites W2894883593 @default.
• W3112309023 cites W2906590066 @default.
• W3112309023 cites W2908678949 @default.
• W3112309023 cites W2916429596 @default.
• W3112309023 cites W2923081322 @default.
• W3112309023 cites W2935824737 @default.
• W3112309023 cites W4247936073 @default.
• W3112309023 doi "https://doi.org/10.1016/j.ejphar.2020.173820" @default.
• W3112309023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33345847" @default.
• W3112309023 hasPublicationYear "2021" @default.
• W3112309023 type Work @default.
• W3112309023 sameAs 3112309023 @default.
• W3112309023 citedByCount "2" @default.
• W3112309023 countsByYear W31123090232022 @default.
• W3112309023 countsByYear W31123090232023 @default.
• W3112309023 crossrefType "journal-article" @default.
• W3112309023 hasAuthorship W3112309023A5011607554 @default.
• W3112309023 hasAuthorship W3112309023A5021409111 @default.
• W3112309023 hasAuthorship W3112309023A5037716681 @default.
• W3112309023 hasAuthorship W3112309023A5037781679 @default.
• W3112309023 hasAuthorship W3112309023A5039085563 @default.
• W3112309023 hasAuthorship W3112309023A5091135752 @default.
• W3112309023 hasConcept C118303440 @default.
• W3112309023 hasConcept C126322002 @default.
• W3112309023 hasConcept C15490471 @default.
• W3112309023 hasConcept C170493617 @default.
• W3112309023 hasConcept C1862650 @default.
• W3112309023 hasConcept C2776401185 @default.
• W3112309023 hasConcept C2776533618 @default.
• W3112309023 hasConcept C2777107010 @default.
• W3112309023 hasConcept C2777803847 @default.
• W3112309023 hasConcept C2777883359 @default.
• W3112309023 hasConcept C2778938600 @default.
• W3112309023 hasConcept C2779245659 @default.
• W3112309023 hasConcept C2780820201 @default.
• W3112309023 hasConcept C2781063702 @default.
• W3112309023 hasConcept C2781118164 @default.
• W3112309023 hasConcept C2781149210 @default.
• W3112309023 hasConcept C42219234 @default.

• next