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• W3112384730 endingPage "100994" @default.
• W3112384730 startingPage "100994" @default.
• W3112384730 abstract "• PD-L1 expression in HGSOC requires further study with modern antibody reagents and platforms. • The association of PD-L1 positive cases with CD8+ immune cells is more prominent. • The checkpoint value in HGSOC is not yet clear, but there is an importance meaningful when the threshold is ≥5%. • PD-L1 expression shows two immunohistochemical staining patterns, patchy/diffuse and patchy/focal. We investigated programmed cell death 1 (PD-1) / programmed cell death ligand 1 (PD-L1) expression in high grade serous ovarian cancer (HGSOC) and its relationship to tumor infiltrating lymphocytes (TIL) and prognosis. Formalin fixed paraffin embedded (FFPE) samples of 94 HGSOC cases were included in the study. Immunohistochemical analysis (CD3, CD4, CD8, PD-1 and PD-L1) was performed. Samples were analyzed for expression of immune proteins in the peritumoral stromal and intratumoral areas, scored, and expression was correlated with overall survival, stage, and age. PD-L1 staining ratio with a score greater than 0 was found to have lower survival. There were two positive staining patterns, patchy/diffuse and patchy/focal patterns, in 24 (25.5%) cases. Considering the threshold value ≥5%, we demonstrated that the PD-L1 positive cancer cell membrane immunoreactivity rate and patchy/diffuse PD-L1 expression were 9.6% (n = 9). There was statistically significant relationship between high PD-1 scores and PD-L1 cases of ≥ 5%. A statistically significant difference was found between PD-L1 staining and survival in patients with a threshold ≥ 5%. However an appropriate rate for treatment was determined in 9.6% cases. There was a statistically significant correlation between PD-1 positive TIL score and intratumoral CD3, peritumoral stromal CD3, intratumoral CD4 and intratumoral CD8 positive cells. Survival was lower in cases with higher PD-L1 positive stromal TIL score." @default.
• W3112384730 created "2020-12-21" @default.
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• W3112384730 date "2021-02-01" @default.
• W3112384730 modified "2023-10-14" @default.
• W3112384730 title "Clinical and pathological significance of programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) expression in high grade serous ovarian cancer" @default.
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• W3112384730 doi "https://doi.org/10.1016/j.tranon.2020.100994" @default.
• W3112384730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7736714" @default.
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