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- W3112486730 abstract "3 % hypertonic saline (HS) is a hyperosmolar agent often used to treat elevated intracranial pressure (ICP). However, the resultant hyperchloremia is associated with adverse outcomes in certain patient populations. In this study, HS solution buffered with sodium acetate (HSwSA) is used as an alternative to standard 3 % formulations to reduce overall chloride exposure. Our objectives are to establish whether this alternative agent – with reduced chloride content – is similar to standard 3 % HS in maintaining hyperosmolarity and investigate its effects on hyperchloremia." @default.
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- W3112486730 date "2021-02-01" @default.
- W3112486730 modified "2023-09-26" @default.
- W3112486730 title "Hypertonic saline buffered with sodium acetate for intracranial pressure management" @default.
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- W3112486730 doi "https://doi.org/10.1016/j.clineuro.2020.106435" @default.
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