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• W3112518117 abstract "Limited data were on the acute respiratory responses in the elderly in response to personal exposure of particulate matter (PM). In order to evaluate the changes of airway inflammation and pulmonary functions in the elderly in response to individual exposure of particles (PM 1.0 , PM 2.5 and PM 10 ), we analyzed 43 elderly subjects with either asthma, chronic obstructive pulmonary disease (COPD) or Asthma COPD Overlap (ACO) and 40 age-matched subjects without asthma nor COPD in an urban community in Shanghai, China. Data were collected at the baseline and in 6 follow-ups from August 2016 to December 2018, once every 3 months except for the last twice with a 6-month interval. In each follow-up, pulmonary functions, fractional exhaled nitric oxide (FeNO), 7-day continuous personal exposure to airborne particles were measured. Multivariate linear mixed effect regression models were applied to investigate the quantitative changes of pulmonary functions and FeNO in two respective groups. The results showed that on average 4.7 follow-up visits were completed in each participant. In subjects with CRDs, an inter-quartile range (IQR) increase of personal exposure to PM 1.0 , PM 2.5 and PM 10 was significantly associated with an average increase of FeNO(Lag1) of 6.7 ppb (95%CI 1.2, 9.9 ppb), 6.2 ppb (95%CI 1.5, 12.0 ppb) and 5.6 ppb (95%CI 1.5, 11.0 ppb), respectively, and an average decrease of FEV1(Lag2) of −3.6 L (95%CI -6.0, −1.1 L), −3.6 L (95%CI -6.4, −0.8 L) and −3.2 L (95%CI -5.8, −0.6 L), respectively, in the single-pollutant model. These associations remained consistent in the two-pollutant models adjusting for gaseous air pollutants. Stratified analysis showed that subjects with lower BMI, females and non-allergies were more sensitive to particle exposure. No robust significant effects were observed in the subjects without CRDs. Our study provided data on the susceptibility of the elderly with CRDs to particle exposure of PM 1.0 and PM 2.5 , and the modification effects by BMI, gender and history of allergies. • PM 1.0 and PM 2.5 had greater impacts than PM 10 on respiratory health in the elderly. • Elderly females and lower-BMI subjects were more susceptible to particle exposure. • Effects of particle exposure were observed in non-allergy subjects, not allergy ones." @default.
• W3112518117 created "2020-12-21" @default.
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• W3112518117 date "2021-02-01" @default.
• W3112518117 modified "2023-10-16" @default.
• W3112518117 title "Acute respiratory response to individual particle exposure (PM1.0, PM2.5 and PM10) in the elderly with and without chronic respiratory diseases" @default.
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• W3112518117 doi "https://doi.org/10.1016/j.envpol.2020.116329" @default.
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