FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3112552609> ?p ?o ?g. }

• W3112552609 endingPage "69" @default.
• W3112552609 startingPage "59" @default.
• W3112552609 abstract "It was previously thought that estrogen deficiency caused hot flushes and night sweats or vasomotor symptoms (VMS). However, VMS also present in women in the Late Reproductive Transition or “Very Early Perimenopause” who still have regular menstrual cycles and whose estrogen levels have not decreased. Social emotional stresses increase VMS that, in turn, increase stress hormones and mood changes. Evidence suggests that downward swings of estradiol (E2) cause the dramatic neuroendocrine/cytokine release with elevated central norepinephrine levels leading to thermoneutral zone narrowing and VMS. There are aspects of the physiology of VMS that resemble “estrogen addiction”. The aim of this review is to integrate scientific and clinical VMS knowledge in a new paradigm within the model of balanced estradiol and progesterone levels for women’s optimal health. We reviewed studies focusing on VMS and its risk factors, pathophysiology and treatment on PubMed, MEDLINE, and EMBASE. Estrogen withdrawal stimulates release of a host of cytokines and neurotransmitters most important of which is increased NE. Downward E2 levels are also associated with anxiety and depression. Initially premenopausal women made menopausal by bilateral ovariectomy/chemotherapy with rapid E2 decline are more likely to report severe VMS than those with natural reproductive aging. When E2 levels drop, increased central NE neuroendocrine-thermal dysregulation triggers hot flushes/night sweats. Although E2-based menopausal hormone therapy relieves VMS, its discontinuation often produces a VMS rebound. P4 relieves VMS in both menopausal and perimenopausal women likely by decreasing or stabilizing NE. We hypothesize that the rebound on discontinuing E2 therapy could be prevented by first adding P4 and then gradually weaning off E2. The effects—of E2 withdrawal, and high E2 levels to increase, and of full dose P4 to suppress central NE levels—need further documentation. Several primate studies and clinical and controlled trials are needed to test this new model. High brain E2 exposure followed by E2 withdrawal rather than low estrogen per se is the underlying cause of VMS; P4 counterbalances the varying E2 levels in the premenopausal years. P4 therapy in perimenopause/menopause may effectively decrease or prevent hot flushes/night sweats without the risk of withdrawal VMS increases that are related to stopping E2 therapy." @default.
• W3112552609 created "2020-12-21" @default.
• W3112552609 creator A5000437146 @default.
• W3112552609 creator A5027489501 @default.
• W3112552609 creator A5030380172 @default.
• W3112552609 creator A5078841587 @default.
• W3112552609 date "2020-01-01" @default.
• W3112552609 modified "2023-10-14" @default.
• W3112552609 title "Paradigm shift in pathophysiology of vasomotor symptoms: Effects of estradiol withdrawal and progesterone therapy" @default.
• W3112552609 cites W181746296 @default.
• W3112552609 cites W1970386643 @default.
• W3112552609 cites W1972113633 @default.
• W3112552609 cites W1973170233 @default.
• W3112552609 cites W1980879435 @default.
• W3112552609 cites W1983190335 @default.
• W3112552609 cites W1983877611 @default.
• W3112552609 cites W1990899486 @default.
• W3112552609 cites W1995780952 @default.
• W3112552609 cites W1996794112 @default.
• W3112552609 cites W2005911905 @default.
• W3112552609 cites W2014187001 @default.
• W3112552609 cites W2014920119 @default.
• W3112552609 cites W2021483854 @default.
• W3112552609 cites W2021974694 @default.
• W3112552609 cites W2022105365 @default.
• W3112552609 cites W2036614660 @default.
• W3112552609 cites W2037245831 @default.
• W3112552609 cites W2038962211 @default.
• W3112552609 cites W2045114930 @default.
• W3112552609 cites W2047321638 @default.
• W3112552609 cites W2051559140 @default.
• W3112552609 cites W2055275826 @default.
• W3112552609 cites W2055926682 @default.
• W3112552609 cites W2056357500 @default.
• W3112552609 cites W2058507144 @default.
• W3112552609 cites W2059392094 @default.
• W3112552609 cites W2060488963 @default.
• W3112552609 cites W2060551064 @default.
• W3112552609 cites W2062232213 @default.
• W3112552609 cites W2067116629 @default.
• W3112552609 cites W2071283124 @default.
• W3112552609 cites W2079452576 @default.
• W3112552609 cites W2085399041 @default.
• W3112552609 cites W2090106271 @default.
• W3112552609 cites W2093821801 @default.
• W3112552609 cites W2093874183 @default.
• W3112552609 cites W2093930904 @default.
• W3112552609 cites W2104017695 @default.
• W3112552609 cites W2106286936 @default.
• W3112552609 cites W2106887831 @default.
• W3112552609 cites W2110993073 @default.
• W3112552609 cites W2111890533 @default.
• W3112552609 cites W2116940555 @default.
• W3112552609 cites W2117920697 @default.
• W3112552609 cites W2119919530 @default.
• W3112552609 cites W2123511777 @default.
• W3112552609 cites W2123813176 @default.
• W3112552609 cites W2124167012 @default.
• W3112552609 cites W2129265504 @default.
• W3112552609 cites W2130653017 @default.
• W3112552609 cites W2132849153 @default.
• W3112552609 cites W2138196253 @default.
• W3112552609 cites W2140723362 @default.
• W3112552609 cites W2142686356 @default.
• W3112552609 cites W2146443363 @default.
• W3112552609 cites W2147551338 @default.
• W3112552609 cites W2149856308 @default.
• W3112552609 cites W2153216542 @default.
• W3112552609 cites W2156719614 @default.
• W3112552609 cites W2158653697 @default.
• W3112552609 cites W2158799130 @default.
• W3112552609 cites W2162257271 @default.
• W3112552609 cites W2162828018 @default.
• W3112552609 cites W2163523216 @default.
• W3112552609 cites W2173586075 @default.
• W3112552609 cites W2332804503 @default.
• W3112552609 cites W2399737357 @default.
• W3112552609 cites W2486836655 @default.
• W3112552609 cites W2506562922 @default.
• W3112552609 cites W2531506996 @default.
• W3112552609 cites W2604459583 @default.
• W3112552609 cites W2604592302 @default.
• W3112552609 cites W2967197476 @default.
• W3112552609 cites W2969667859 @default.
• W3112552609 cites W2989192759 @default.
• W3112552609 cites W3028765772 @default.
• W3112552609 cites W4246582895 @default.
• W3112552609 cites W4250331788 @default.
• W3112552609 cites W4253725481 @default.
• W3112552609 cites W4295990640 @default.
• W3112552609 cites W95785129 @default.
• W3112552609 doi "https://doi.org/10.1016/j.ddmod.2020.11.004" @default.
• W3112552609 hasPublicationYear "2020" @default.
• W3112552609 type Work @default.
• W3112552609 sameAs 3112552609 @default.
• W3112552609 citedByCount "1" @default.
• W3112552609 countsByYear W31125526092023 @default.
• W3112552609 crossrefType "journal-article" @default.

• next