Matches in SemOpenAlex for { <https://semopenalex.org/work/W3112565558> ?p ?o ?g. }
- W3112565558 endingPage "111335" @default.
- W3112565558 startingPage "111335" @default.
- W3112565558 abstract "A series of iminopyridine complexes of platinum(II), bearing a flexible diethereal, aryl terminated residue, where the size of aryl group is varied from phenyl to 9-anthracenyl, was synthesized. The new complexes are soluble and stable in DMSO/H2O mixtures. Besides the metal center, aryl groups are available for further interactions with DNA, due to the good side chain flexibility. The new aryl functionalized iminopyridine dichlorido platinum(II) complexes show a significant antiproliferative activity on ovarian carcinoma cells and notably, complex 13 is able to overcome cisplatin resistance. The study of the interaction mode of 13 with DNA highlighted the ability to form a molecular complex characterized by a dual (intercalative and groove binding) geometry. The complex is also able to covalently add to DNA even though interstrand cross-links appear significantly hampered with respect to cisplatin. The interactions with the macromolecule are discussed in view of the observed cell effect." @default.
- W3112565558 created "2020-12-21" @default.
- W3112565558 creator A5023556971 @default.
- W3112565558 creator A5044817705 @default.
- W3112565558 creator A5060733575 @default.
- W3112565558 creator A5062096538 @default.
- W3112565558 creator A5069513373 @default.
- W3112565558 creator A5070296521 @default.
- W3112565558 creator A5076172024 @default.
- W3112565558 date "2021-03-01" @default.
- W3112565558 modified "2023-10-02" @default.
- W3112565558 title "Cytotoxicity and DNA interaction in a series of aryl terminated iminopyridine Pt(II) complexes" @default.
- W3112565558 cites W1093522065 @default.
- W3112565558 cites W145577621 @default.
- W3112565558 cites W1586119447 @default.
- W3112565558 cites W1956734002 @default.
- W3112565558 cites W1971680076 @default.
- W3112565558 cites W1976404311 @default.
- W3112565558 cites W1980269330 @default.
- W3112565558 cites W1980411311 @default.
- W3112565558 cites W1987604182 @default.
- W3112565558 cites W1991399543 @default.
- W3112565558 cites W1994677283 @default.
- W3112565558 cites W1999235659 @default.
- W3112565558 cites W2004648014 @default.
- W3112565558 cites W2020261616 @default.
- W3112565558 cites W2039683233 @default.
- W3112565558 cites W2042619042 @default.
- W3112565558 cites W2052241603 @default.
- W3112565558 cites W2056116492 @default.
- W3112565558 cites W2058985277 @default.
- W3112565558 cites W2059035986 @default.
- W3112565558 cites W2059394181 @default.
- W3112565558 cites W2059779853 @default.
- W3112565558 cites W2063334178 @default.
- W3112565558 cites W2067191808 @default.
- W3112565558 cites W2085888337 @default.
- W3112565558 cites W2126544114 @default.
- W3112565558 cites W2147639456 @default.
- W3112565558 cites W2157074499 @default.
- W3112565558 cites W2159515687 @default.
- W3112565558 cites W2236515064 @default.
- W3112565558 cites W2346099313 @default.
- W3112565558 cites W2565643793 @default.
- W3112565558 cites W2789885602 @default.
- W3112565558 cites W2897926526 @default.
- W3112565558 cites W2910282721 @default.
- W3112565558 cites W2910463953 @default.
- W3112565558 cites W2910892797 @default.
- W3112565558 cites W2912777266 @default.
- W3112565558 cites W2914653692 @default.
- W3112565558 cites W2973003172 @default.
- W3112565558 cites W2981785045 @default.
- W3112565558 cites W299843295 @default.
- W3112565558 cites W2998832889 @default.
- W3112565558 cites W3013083999 @default.
- W3112565558 cites W3019040904 @default.
- W3112565558 cites W3032246542 @default.
- W3112565558 cites W4246269752 @default.
- W3112565558 doi "https://doi.org/10.1016/j.jinorgbio.2020.111335" @default.
- W3112565558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33360320" @default.
- W3112565558 hasPublicationYear "2021" @default.
- W3112565558 type Work @default.
- W3112565558 sameAs 3112565558 @default.
- W3112565558 citedByCount "3" @default.
- W3112565558 countsByYear W31125655582021 @default.
- W3112565558 countsByYear W31125655582022 @default.
- W3112565558 countsByYear W31125655582023 @default.
- W3112565558 crossrefType "journal-article" @default.
- W3112565558 hasAuthorship W3112565558A5023556971 @default.
- W3112565558 hasAuthorship W3112565558A5044817705 @default.
- W3112565558 hasAuthorship W3112565558A5060733575 @default.
- W3112565558 hasAuthorship W3112565558A5062096538 @default.
- W3112565558 hasAuthorship W3112565558A5069513373 @default.
- W3112565558 hasAuthorship W3112565558A5070296521 @default.
- W3112565558 hasAuthorship W3112565558A5076172024 @default.
- W3112565558 hasConcept C109316439 @default.
- W3112565558 hasConcept C141071460 @default.
- W3112565558 hasConcept C161790260 @default.
- W3112565558 hasConcept C178790620 @default.
- W3112565558 hasConcept C180577832 @default.
- W3112565558 hasConcept C185592680 @default.
- W3112565558 hasConcept C202751555 @default.
- W3112565558 hasConcept C204389451 @default.
- W3112565558 hasConcept C204921945 @default.
- W3112565558 hasConcept C21951064 @default.
- W3112565558 hasConcept C2776694085 @default.
- W3112565558 hasConcept C2778239845 @default.
- W3112565558 hasConcept C2780263894 @default.
- W3112565558 hasConcept C2781076698 @default.
- W3112565558 hasConcept C518104683 @default.
- W3112565558 hasConcept C521977710 @default.
- W3112565558 hasConcept C552990157 @default.
- W3112565558 hasConcept C55493867 @default.
- W3112565558 hasConcept C71240020 @default.
- W3112565558 hasConcept C71924100 @default.
- W3112565558 hasConceptScore W3112565558C109316439 @default.
- W3112565558 hasConceptScore W3112565558C141071460 @default.