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- W3112580549 abstract "One of the greatest threats to human health is the rise in antibiotic-resistant bacterial infections. Pseudomonas aeruginosa (PsA) is an “opportunistic” pathogen known to cause life-threatening infections in immunocompromised individuals and is the most common pathogen in adults with cystic fibrosis (CF). We report here a cationic zinc (II) porphyrin, ZnPor, that effectively kills planktonic and biofilm-associated cells of PsA. In standard tests against 16–18 h-old biofilms, concentrations as low as 16 µg/mL resulted in the extensive disruption and detachment of the matrix. The pre-treatment of biofilms for 30 min with ZnPor at minimum inhibitory concentration (MIC) levels (4 µg/mL) substantially enhanced the ability of tobramycin (Tobra) to kill biofilm-associated cells. We demonstrate the rapid uptake and accumulation of ZnPor in planktonic cells even in dedicated heme-uptake system mutants (ΔPhu, ΔHas, and the double mutant). Furthermore, uptake was unaffected by the ionophore carbonyl cyanide m-chlorophenyl hydrazine (CCCP). Cells pre-exposed to ZnPor took up the cell-impermeant dye SYTOXTM Green in a concentration-dependent manner. The accumulation of ZnPor did not result in cell lysis, nor did the cells develop resistance. Taken together, these properties make ZnPor a promising candidate for treating multi-drug-resistant infections, including persistent, antibiotic-resistant biofilms." @default.
- W3112580549 created "2020-12-21" @default.
- W3112580549 creator A5047086059 @default.
- W3112580549 creator A5058360686 @default.
- W3112580549 creator A5062534048 @default.
- W3112580549 date "2020-12-06" @default.
- W3112580549 modified "2023-09-23" @default.
- W3112580549 title "A Cationic Porphyrin, ZnPor, Disassembles Pseudomonas aeruginosa Biofilm Matrix, Kills Cells Directly, and Enhances Antibiotic Activity of Tobramycin" @default.
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- W3112580549 doi "https://doi.org/10.3390/antibiotics9120875" @default.
- W3112580549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7762324" @default.
- W3112580549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33291344" @default.
- W3112580549 hasPublicationYear "2020" @default.
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