Matches in SemOpenAlex for { <https://semopenalex.org/work/W3112598972> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3112598972 endingPage "ii190" @default.
- W3112598972 startingPage "ii190" @default.
- W3112598972 abstract "Abstract While meningiomas are commonly benign brain tumors, as many as 30% may be classified as atypical, or WHO Grade 2. Patients are at risk of recurrence following resection and often are prescribed adjuvant radiation therapy (RT)-although most data on this treatment is retrospective and has shown mixed RESULTS: In this study we assessed the influence of adjuvant RT following gross total resection (GTR) in patients with newly diagnosed atypical meningiomas at our institution and sought to determine predictors of tumor recurrence. All patients who underwent GTR (Simpson Grade I and II) at their index operation from 1994-2014 were retrospectively reviewed. Patients then either underwent observation or adjuvant RT (Intensity-Modulated Radiation Therapy (IMRT) or stereotactic radiosurgery (SRS)). A total of 145 patients had documented GTR at the time of initial resection, including 88 females (61%) and 57 males (39%), with a mean age of 58 +/- 15.7 years. 118 patients were followed with observation after surgery while 27 (18.6%) patients received adjuvant RT prior to known recurrence (IMRT for 15 patients (55.5%) and SRS in 12 patients (44.4%)). Patients receiving adjuvant RT had significantly larger tumors, as well as a higher incidence of spontaneous necrosis and small cell phenotype on histopathology. Overall 5-year PFS in our cohort was 71.6% (CI 60.6%-84.7%) and was unchanged by adjuvant RT (p = 0.52). 23 patients (15.8%) had a recurrence with a mean follow up of 42.9 months (17.1-53.5 months). Male gender (HR=1.02, p=0.019), tumor size (HR=1.17, p= 0.002) and MIB-1 > 4 (HR=8.50, p=0.04) were associated with increased recurrence risk. There was no association between radiation type (SRS vs. IMRT) and risk of recurrence (p= 0.154). In our patients, adjuvant RT following GTR of atypical meningiomas did not improve PFS. Risk factors for recurrence included male gender, larger tumor size, and MIB-1 > 4." @default.
- W3112598972 created "2020-12-21" @default.
- W3112598972 creator A5014158466 @default.
- W3112598972 creator A5029397539 @default.
- W3112598972 creator A5033226431 @default.
- W3112598972 creator A5033293845 @default.
- W3112598972 creator A5042756267 @default.
- W3112598972 creator A5050335101 @default.
- W3112598972 creator A5083930804 @default.
- W3112598972 date "2020-11-01" @default.
- W3112598972 modified "2023-10-14" @default.
- W3112598972 title "RADT-41. ASSESSING THE ROLE OF ADJUVANT RADIATION THERAPY AND RISK FACTORS FOR RECURRENCE FOLLOWING GROSS TOTAL RESECTION OF ATYPICAL MENINGIOMAS" @default.
- W3112598972 doi "https://doi.org/10.1093/neuonc/noaa215.794" @default.
- W3112598972 hasPublicationYear "2020" @default.
- W3112598972 type Work @default.
- W3112598972 sameAs 3112598972 @default.
- W3112598972 citedByCount "0" @default.
- W3112598972 crossrefType "journal-article" @default.
- W3112598972 hasAuthorship W3112598972A5014158466 @default.
- W3112598972 hasAuthorship W3112598972A5029397539 @default.
- W3112598972 hasAuthorship W3112598972A5033226431 @default.
- W3112598972 hasAuthorship W3112598972A5033293845 @default.
- W3112598972 hasAuthorship W3112598972A5042756267 @default.
- W3112598972 hasAuthorship W3112598972A5050335101 @default.
- W3112598972 hasAuthorship W3112598972A5083930804 @default.
- W3112598972 hasBestOaLocation W31125989721 @default.
- W3112598972 hasConcept C120665830 @default.
- W3112598972 hasConcept C121332964 @default.
- W3112598972 hasConcept C126322002 @default.
- W3112598972 hasConcept C141071460 @default.
- W3112598972 hasConcept C142724271 @default.
- W3112598972 hasConcept C167135981 @default.
- W3112598972 hasConcept C2776694085 @default.
- W3112598972 hasConcept C2777863537 @default.
- W3112598972 hasConcept C2777982462 @default.
- W3112598972 hasConcept C2780387249 @default.
- W3112598972 hasConcept C3018454096 @default.
- W3112598972 hasConcept C509974204 @default.
- W3112598972 hasConcept C544855455 @default.
- W3112598972 hasConcept C61511704 @default.
- W3112598972 hasConcept C71924100 @default.
- W3112598972 hasConcept C72563966 @default.
- W3112598972 hasConceptScore W3112598972C120665830 @default.
- W3112598972 hasConceptScore W3112598972C121332964 @default.
- W3112598972 hasConceptScore W3112598972C126322002 @default.
- W3112598972 hasConceptScore W3112598972C141071460 @default.
- W3112598972 hasConceptScore W3112598972C142724271 @default.
- W3112598972 hasConceptScore W3112598972C167135981 @default.
- W3112598972 hasConceptScore W3112598972C2776694085 @default.
- W3112598972 hasConceptScore W3112598972C2777863537 @default.
- W3112598972 hasConceptScore W3112598972C2777982462 @default.
- W3112598972 hasConceptScore W3112598972C2780387249 @default.
- W3112598972 hasConceptScore W3112598972C3018454096 @default.
- W3112598972 hasConceptScore W3112598972C509974204 @default.
- W3112598972 hasConceptScore W3112598972C544855455 @default.
- W3112598972 hasConceptScore W3112598972C61511704 @default.
- W3112598972 hasConceptScore W3112598972C71924100 @default.
- W3112598972 hasConceptScore W3112598972C72563966 @default.
- W3112598972 hasIssue "Supplement_2" @default.
- W3112598972 hasLocation W31125989721 @default.
- W3112598972 hasLocation W31125989722 @default.
- W3112598972 hasLocation W31125989723 @default.
- W3112598972 hasOpenAccess W3112598972 @default.
- W3112598972 hasPrimaryLocation W31125989721 @default.
- W3112598972 hasRelatedWork W113533277 @default.
- W3112598972 hasRelatedWork W2003271565 @default.
- W3112598972 hasRelatedWork W2058106962 @default.
- W3112598972 hasRelatedWork W2098604088 @default.
- W3112598972 hasRelatedWork W2566574777 @default.
- W3112598972 hasRelatedWork W2768104750 @default.
- W3112598972 hasRelatedWork W2912482234 @default.
- W3112598972 hasRelatedWork W3083557663 @default.
- W3112598972 hasRelatedWork W3177593498 @default.
- W3112598972 hasRelatedWork W4297265542 @default.
- W3112598972 hasVolume "22" @default.
- W3112598972 isParatext "false" @default.
- W3112598972 isRetracted "false" @default.
- W3112598972 magId "3112598972" @default.
- W3112598972 workType "article" @default.