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- W3112606349 abstract "The expression and turnover of Ag-specific peptide-MHC class II (pMHC-II) on the surface of dendritic cells (DCs) is essential for their ability to efficiently activate CD4 T cells. Ubiquitination of pMHC-II by the E3 ubiquitin ligase March-I regulates surface expression and survival of pMHC-II in DCs. We now show that despite their high levels of surface pMHC-II, MHC class II (MHC-II) ubiquitination-deficient mouse DCs are functionally defective; they are poor stimulators of naive CD4 T cells and secrete IL-12 in response to LPS stimulation poorly. MHC-II ubiquitination-mutant DC defects are cell intrinsic, and single-cell RNA sequencing demonstrates that these DCs have an altered gene expression signature as compared with wild-type DCs. Curiously, these functional and gene transcription defects are reversed by activating the DCs with LPS. These results show that dysregulation of MHC-II turnover suppresses DC development and function." @default.
- W3112606349 created "2020-12-21" @default.
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- W3112606349 date "2021-02-01" @default.
- W3112606349 modified "2023-10-01" @default.
- W3112606349 title "Ubiquitination of MHC Class II by March-I Regulates Dendritic Cell Fitness" @default.
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- W3112606349 doi "https://doi.org/10.4049/jimmunol.2000975" @default.
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