FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3112639240> ?p ?o ?g. }

• W3112639240 endingPage "170" @default.
• W3112639240 startingPage "159" @default.
• W3112639240 abstract "Background: Although abnormalities in gut microbiota are hypothesized to influence the pathogenesis and clinical phenotype of Parkinson’s disease (PD), prospective studies on de novo patients are lacking. Objective: To preliminarily investigate whether gut microbiota in early untreated PD may predict motor and non-motor features progression over a 3-year period. Methods: 16S ribosomal RNA gene amplicons were sequenced on fecal samples of 39 de novo PD patients. Multiple confounders were taken into account, including dietary habits. Motor and non-motor symptoms were assessed using validated scales at baseline and followed-up yearly for 3 years. At last follow-up, a detailed neuropsychological assessment was additionally performed. A general linear model for repeated measurements— adjusted by dopaminergic therapy at follow-up— was used to investigate the relationship between bacterial taxa abundance at baseline (stratified by the median of distribution at baseline) and outcome variables. Results: Twenty-five patients were included (11 refused, 2 lost at follow-up, 1 died). Lower abundance of Roseburia (Firmicutes phylum) at baseline was associated with worse evolution of motor, non-motor and cognitive functions at 3-year follow-up. Similarly, lower abundance of Ruminococcaceae and Actinobacteria at baseline was associated with faster worsening of global cognitive functions. At follow-up, frontal lobe functions were the features most robustly associated with baseline microbial abnormalities. Conclusion: In the present exploratory study on de novo PD, we found an association between abnormal distribution of specific bacterial taxa and the progression of motor and non-motor features over a 3-year period. This proof-of-principle study supports the design of a larger observational study aiming to determine whether these differences survive multiple-comparison correction and define microbiota-specific subgroups suitable for therapeutic targeting." @default.
• W3112639240 created "2020-12-21" @default.
• W3112639240 creator A5004945559 @default.
• W3112639240 creator A5015821522 @default.
• W3112639240 creator A5025574771 @default.
• W3112639240 creator A5030097040 @default.
• W3112639240 creator A5046500384 @default.
• W3112639240 creator A5054301985 @default.
• W3112639240 creator A5057187099 @default.
• W3112639240 creator A5063552454 @default.
• W3112639240 creator A5063939364 @default.
• W3112639240 creator A5068859035 @default.
• W3112639240 creator A5073410236 @default.
• W3112639240 creator A5087769392 @default.
• W3112639240 date "2021-02-02" @default.
• W3112639240 modified "2023-10-03" @default.
• W3112639240 title "Does Gut Microbiota Influence the Course of Parkinson’s Disease? A 3-Year Prospective Exploratory Study in de novo Patients" @default.
• W3112639240 cites W1847168837 @default.
• W3112639240 cites W1897291768 @default.
• W3112639240 cites W1903888485 @default.
• W3112639240 cites W1934236512 @default.
• W3112639240 cites W1979495039 @default.
• W3112639240 cites W1983421775 @default.
• W3112639240 cites W1983875169 @default.
• W3112639240 cites W1985542464 @default.
• W3112639240 cites W1993662614 @default.
• W3112639240 cites W2028545182 @default.
• W3112639240 cites W2045833477 @default.
• W3112639240 cites W2051773180 @default.
• W3112639240 cites W2064996887 @default.
• W3112639240 cites W2070003162 @default.
• W3112639240 cites W2080340510 @default.
• W3112639240 cites W2080732726 @default.
• W3112639240 cites W2089085990 @default.
• W3112639240 cites W2111574450 @default.
• W3112639240 cites W2112455323 @default.
• W3112639240 cites W2168946626 @default.
• W3112639240 cites W2256778397 @default.
• W3112639240 cites W2294532941 @default.
• W3112639240 cites W2508023300 @default.
• W3112639240 cites W2574256641 @default.
• W3112639240 cites W2587959748 @default.
• W3112639240 cites W2607019262 @default.
• W3112639240 cites W2616539606 @default.
• W3112639240 cites W2619485173 @default.
• W3112639240 cites W2746835184 @default.
• W3112639240 cites W2756066122 @default.
• W3112639240 cites W2761210275 @default.
• W3112639240 cites W2766355490 @default.
• W3112639240 cites W2799884346 @default.
• W3112639240 cites W2803911255 @default.
• W3112639240 cites W2895971387 @default.
• W3112639240 cites W2906418973 @default.
• W3112639240 cites W2912555658 @default.
• W3112639240 cites W2951344089 @default.
• W3112639240 cites W2954935089 @default.
• W3112639240 cites W2995190362 @default.
• W3112639240 cites W3000501046 @default.
• W3112639240 cites W3009775645 @default.
• W3112639240 cites W4211123396 @default.
• W3112639240 doi "https://doi.org/10.3233/jpd-202297" @default.
• W3112639240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33337387" @default.
• W3112639240 hasPublicationYear "2021" @default.
• W3112639240 type Work @default.
• W3112639240 sameAs 3112639240 @default.
• W3112639240 citedByCount "26" @default.
• W3112639240 countsByYear W31126392402021 @default.
• W3112639240 countsByYear W31126392402022 @default.
• W3112639240 countsByYear W31126392402023 @default.
• W3112639240 crossrefType "journal-article" @default.
• W3112639240 hasAuthorship W3112639240A5004945559 @default.
• W3112639240 hasAuthorship W3112639240A5015821522 @default.
• W3112639240 hasAuthorship W3112639240A5025574771 @default.
• W3112639240 hasAuthorship W3112639240A5030097040 @default.
• W3112639240 hasAuthorship W3112639240A5046500384 @default.
• W3112639240 hasAuthorship W3112639240A5054301985 @default.
• W3112639240 hasAuthorship W3112639240A5057187099 @default.
• W3112639240 hasAuthorship W3112639240A5063552454 @default.
• W3112639240 hasAuthorship W3112639240A5063939364 @default.
• W3112639240 hasAuthorship W3112639240A5068859035 @default.
• W3112639240 hasAuthorship W3112639240A5073410236 @default.
• W3112639240 hasAuthorship W3112639240A5087769392 @default.
• W3112639240 hasConcept C126322002 @default.
• W3112639240 hasConcept C143121216 @default.
• W3112639240 hasConcept C188816634 @default.
• W3112639240 hasConcept C203014093 @default.
• W3112639240 hasConcept C2779134260 @default.
• W3112639240 hasConcept C42407357 @default.
• W3112639240 hasConcept C539455810 @default.
• W3112639240 hasConcept C60644358 @default.
• W3112639240 hasConcept C71924100 @default.
• W3112639240 hasConcept C77350462 @default.
• W3112639240 hasConcept C86803240 @default.
• W3112639240 hasConceptScore W3112639240C126322002 @default.
• W3112639240 hasConceptScore W3112639240C143121216 @default.
• W3112639240 hasConceptScore W3112639240C188816634 @default.
• W3112639240 hasConceptScore W3112639240C203014093 @default.
• W3112639240 hasConceptScore W3112639240C2779134260 @default.

• next