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• W3112704307 abstract "A parallel, one-pot assembly approach to proteolysis targeting chimeras (PROTACs) is demonstrated utilizing activated esters generated in situ, and traceless Staudinger ligation chemistry. The method described allows for rapid structure-activity relationship studies of PROTAC linker variants. Two previously studied systems, cereblon and BRD4 degraders, are examined as test cases for the synthetic method. The two related strategies to assemble PROTAC linker variants discussed can accommodate the chromotographic separations capabilities of labs of many sizes and incorporates commercially available degrader building blocks, thereby easing synthetic entry into PROTAC chemical space." @default.
• W3112704307 created "2020-12-21" @default.
• W3112704307 creator A5046962073 @default.
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• W3112704307 date "2021-01-01" @default.
• W3112704307 modified "2023-10-06" @default.
• W3112704307 title "Traceless Staudinger ligation enabled parallel synthesis of proteolysis targeting chimera linker variants" @default.
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• W3112704307 doi "https://doi.org/10.1039/d0cc05395c" @default.
• W3112704307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7962863" @default.
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