Matches in SemOpenAlex for { <https://semopenalex.org/work/W3112723777> ?p ?o ?g. }
- W3112723777 endingPage "3651" @default.
- W3112723777 startingPage "3642" @default.
- W3112723777 abstract "Soluble guanylate cyclase (sGC) is the human receptor of nitric oxide (NO) in numerous kinds of cells and produces the second messenger 3',5'-cyclic guanosine monophosphate (cGMP) upon NO binding to its heme. sGC is involved in many cell signaling pathways both under healthy conditions and under pathological conditions, such as angiogenesis associated with tumor growth. Addressing the selective inhibition of the NO/cGMP pathway is a strategy worthwhile to be investigated for slowing down tumoral angiogenesis or for curing vasoplegia. However, sGC inhibitors are lacking investigation. We have explored a chemical library of various natural compounds and have discovered inhibitors of sGC. The selected compounds were evaluated for their inhibition of purified sGC in vitro and sGC in endothelial cells. Six natural compounds, from various organisms, have IC50 in the range 0.2-1.5 μM for inhibiting the NO-activated synthesis of cGMP by sGC, and selected compounds exhibit a quantified antiangiogenic activity using an endothelial cell line. These sGC inhibitors can be used directly as tools to investigate angiogenesis and cell signaling or as templates for drug design." @default.
- W3112723777 created "2020-12-21" @default.
- W3112723777 creator A5004392276 @default.
- W3112723777 creator A5012003360 @default.
- W3112723777 creator A5043306592 @default.
- W3112723777 creator A5056751083 @default.
- W3112723777 creator A5073358253 @default.
- W3112723777 date "2020-12-08" @default.
- W3112723777 modified "2023-10-17" @default.
- W3112723777 title "Soluble Guanylate Cyclase Inhibitors Discovered among Natural Compounds" @default.
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