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- W3112757361 abstract "We report a rare case of sebaceous carcinoma arising in the buccal mucosa of the mandibular region. A 51-year-old female presented with an ulcerated swelling with 2 months of evolution. Incisional biopsy was performed, and, microscopically, the lesion showed a proliferation of nests and cords of atypical and pleomorphic epithelial cells. The cytoplasm of the cells had clear changes and vacuoles. Some of them demonstrated clearly sebaceous differentiation. Immunohistochemical studies revealed positivity for cytokeratins 14 and 18, epithelial membrane antigen, and adipophilin. The cellular proliferative index (assessed by Ki-67-nuclear expression) was 70%. The patient was undergoing complete surgical excision and received chemotherapy (6 cycles of paclitaxel and carboplatin 3 times weekly) and died 5 months after the treatment. Sebaceous carcinoma is exceedingly rare in the oral mucosa, and the immunohistochemistry, particularly adipophilin, is essential to its diagnosis. We report a rare case of sebaceous carcinoma arising in the buccal mucosa of the mandibular region. A 51-year-old female presented with an ulcerated swelling with 2 months of evolution. Incisional biopsy was performed, and, microscopically, the lesion showed a proliferation of nests and cords of atypical and pleomorphic epithelial cells. The cytoplasm of the cells had clear changes and vacuoles. Some of them demonstrated clearly sebaceous differentiation. Immunohistochemical studies revealed positivity for cytokeratins 14 and 18, epithelial membrane antigen, and adipophilin. The cellular proliferative index (assessed by Ki-67-nuclear expression) was 70%. The patient was undergoing complete surgical excision and received chemotherapy (6 cycles of paclitaxel and carboplatin 3 times weekly) and died 5 months after the treatment. Sebaceous carcinoma is exceedingly rare in the oral mucosa, and the immunohistochemistry, particularly adipophilin, is essential to its diagnosis." @default.
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- W3112757361 date "2020-09-01" @default.
- W3112757361 modified "2023-10-16" @default.
- W3112757361 title "SEBACEOUS CARCINOMA OF THE ORAL MUCOSA: A CASE REPORT" @default.
- W3112757361 doi "https://doi.org/10.1016/j.oooo.2020.04.030" @default.
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