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- W3112808358 abstract "Hyperphosphatemia is a predictable consequence of advanced chronic kidney disease associated with increased morbidity and mortality in patients undergoing dialysis. To control their serum phosphorus (sP) levels, treatment with phosphate binders (PBs) is required. Sucroferric oxyhydroxide (SO) is a calcium-free PB with higher phosphate binding capacity and lower pill burden. This analysis aims to show that the prescription of SO may give rise to potential inpatient cost-savings for the German healthcare setting. We conduct an economic evaluation analysis using clinical outcomes from a 2 year retrospective RWE study comparing adult in – center dialysis patients with uninterrupted SO prescriptions for two years, with patients who discontinued SO within 90 days of their first prescription and switched to other PBs (oPBs). The size of the population eligible for therapy with PBs in Germany was estimated using literature data. Annual drug costs per PB were quantified, and the observed incidence rates of hospital admissions (all admissions and admissions with length of stay >24 hours) were converted into annual inpatient costs. Subsequently, the net effect of SO versus oPBs in terms of annual drug acquisition costs and annual inpatient costs were estimated. One way and probabilistic sensitivity analyses were also conducted. Treating the PB eligible population (N=34,400) exclusively with SO is expected to increase annual drug costs by €0.41 million compared to treating the population with oPBs. In turn, SO is expected to generate annual inpatient cost-savings of €64.64 million. The estimated net effect shows annual total savings of €64.23 million for the healthcare system when the eligible population is treated with SO. Sensitivity analyses showed the robustness of the results in terms of cost savings. Sucroferric oxyhydroxide is an effective therapy that may result in cost savings from reducing hospital admission costs that are attributable to hyperphosphatemia among dialysis patients in Germany." @default.
- W3112808358 created "2020-12-21" @default.
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- W3112808358 date "2020-12-01" @default.
- W3112808358 modified "2023-09-30" @default.
- W3112808358 title "PUK10 Estimation of Inpatient Cost-Savings of Prescribing Sucroferric Oxyhydroxide in Chronic Kidney Disease Patients Undergoing Dialysis in Germany" @default.
- W3112808358 doi "https://doi.org/10.1016/j.jval.2020.08.2053" @default.
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