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• W3112825095 startingPage "9371" @default.
• W3112825095 abstract "Insights into the modes of action (MoAs) of xenobiotics are of utmost importance for the definition of adverse outcome pathways (AOPs), which are essential for a mechanism-based risk assessment. A well-established strategy to reveal MoAs of xenobiotics is the use of omics. However, often an even more comprehensive approach is needed, which can be achieved using multi-omics. Since the immune system plays a central role in the defense against foreign substances and pathogens, with the innate immune system building a first barrier, we systematically reviewed multi-omics studies investigating the effects of xenobiotics on macrophages. Surprisingly, only nine publications were identified, combining proteomics with transcriptomics or metabolomics. We summarized pathways and single proteins, transcripts, or metabolites, which were described to be affected upon treatment with xenobiotics in the reviewed studies, thus revealing a broad range of effects. In summary, we show that macrophages are a relevant model system to investigate the toxicological effects induced by xenobiotics. Furthermore, the multi-omics approaches led to a more comprehensive overview compared to only one omics layer with slight advantages for combinations that complement each other directly, e.g., proteome and metabolome." @default.
• W3112825095 created "2020-12-21" @default.
• W3112825095 creator A5020179716 @default.
• W3112825095 creator A5052832772 @default.
• W3112825095 creator A5070686533 @default.
• W3112825095 creator A5076028970 @default.
• W3112825095 date "2020-12-09" @default.
• W3112825095 modified "2023-10-16" @default.
• W3112825095 title "Systematic Review of Multi-Omics Approaches to Investigate Toxicological Effects in Macrophages" @default.
• W3112825095 cites W1503311610 @default.
• W3112825095 cites W1926886182 @default.
• W3112825095 cites W1974500649 @default.
• W3112825095 cites W1976750784 @default.
• W3112825095 cites W1978570121 @default.
• W3112825095 cites W1981434053 @default.
• W3112825095 cites W1981509058 @default.
• W3112825095 cites W1983490086 @default.
• W3112825095 cites W1985488986 @default.
• W3112825095 cites W1985859986 @default.
• W3112825095 cites W1989558123 @default.
• W3112825095 cites W1992170087 @default.
• W3112825095 cites W2000089305 @default.
• W3112825095 cites W2001645202 @default.
• W3112825095 cites W2004802360 @default.
• W3112825095 cites W2009004909 @default.
• W3112825095 cites W2012694308 @default.
• W3112825095 cites W2013708530 @default.
• W3112825095 cites W2015636972 @default.
• W3112825095 cites W2020260927 @default.
• W3112825095 cites W2020655249 @default.
• W3112825095 cites W2024392158 @default.
• W3112825095 cites W2024864921 @default.
• W3112825095 cites W2034383978 @default.
• W3112825095 cites W2039893751 @default.
• W3112825095 cites W2045993548 @default.
• W3112825095 cites W2048280438 @default.
• W3112825095 cites W2048424279 @default.
• W3112825095 cites W2050449334 @default.
• W3112825095 cites W2055207393 @default.
• W3112825095 cites W2055719121 @default.
• W3112825095 cites W2060057378 @default.
• W3112825095 cites W2061157014 @default.
• W3112825095 cites W2064081167 @default.
• W3112825095 cites W2067381374 @default.
• W3112825095 cites W2070855360 @default.
• W3112825095 cites W2072462631 @default.
• W3112825095 cites W2073513307 @default.
• W3112825095 cites W2073839595 @default.
• W3112825095 cites W2073875167 @default.
• W3112825095 cites W2075118258 @default.
• W3112825095 cites W2082998950 @default.
• W3112825095 cites W2085578084 @default.
• W3112825095 cites W2092777410 @default.
• W3112825095 cites W2093893930 @default.
• W3112825095 cites W2096428863 @default.
• W3112825095 cites W2097259163 @default.
• W3112825095 cites W2105167594 @default.
• W3112825095 cites W2109770073 @default.
• W3112825095 cites W2113432838 @default.
• W3112825095 cites W2114269157 @default.
• W3112825095 cites W2114390083 @default.
• W3112825095 cites W2115596383 @default.
• W3112825095 cites W2121462818 @default.
• W3112825095 cites W2130124770 @default.
• W3112825095 cites W2130241735 @default.
• W3112825095 cites W2134396365 @default.
• W3112825095 cites W2140946052 @default.
• W3112825095 cites W2147425799 @default.
• W3112825095 cites W2153476889 @default.
• W3112825095 cites W2165804863 @default.
• W3112825095 cites W2170776626 @default.
• W3112825095 cites W2170936782 @default.
• W3112825095 cites W2172675244 @default.
• W3112825095 cites W2182545443 @default.
• W3112825095 cites W2255268777 @default.
• W3112825095 cites W2257458640 @default.
• W3112825095 cites W2257734931 @default.
• W3112825095 cites W2274879598 @default.
• W3112825095 cites W2276765849 @default.
• W3112825095 cites W2290248210 @default.
• W3112825095 cites W2293929620 @default.
• W3112825095 cites W2314600575 @default.
• W3112825095 cites W2334617819 @default.
• W3112825095 cites W2341128841 @default.
• W3112825095 cites W2345735224 @default.
• W3112825095 cites W2407688393 @default.
• W3112825095 cites W2409907752 @default.
• W3112825095 cites W2461989915 @default.
• W3112825095 cites W2468925656 @default.
• W3112825095 cites W2512797033 @default.
• W3112825095 cites W2527715458 @default.
• W3112825095 cites W2530424978 @default.
• W3112825095 cites W2548036975 @default.
• W3112825095 cites W2549805680 @default.
• W3112825095 cites W2565367179 @default.
• W3112825095 cites W2569649477 @default.
• W3112825095 cites W2571216275 @default.
• W3112825095 cites W2580243775 @default.

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