FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3112868319> ?p ?o ?g. }

• W3112868319 abstract "A bstract Host genetic variation plays an important role in the structure and function of heritable microbial communities. Recent studies have demonstrated that insects use immune mechanisms to regulate heritable symbionts. Here we test the hypothesis that variation in symbiont density within hosts is linked to intraspecific differences in the immune response to harboring symbionts. We show that pea aphids ( Acyrthosiphon pisum ) harboring the bacterial endosymbiont Regiella insecticola (but not all other species of symbionts) suppress expression of key immune genes. We then functionally link immune suppression with symbiont density using RNAi. The pea aphid species complex is comprised of multiple reproductively-isolated host plant-adapted populations. These ‘biotypes’ have distinct patterns of heritable symbiont infections: for example, aphids from the Trifolium biotype are strongly associated with Regiella . Using RNAseq, we compare patterns of gene expression in response to Regiella in aphid genotypes from multiple biotypes, and we show that Trifolium aphids experience no immune gene suppression from Regiella and host symbionts at lower densities. We then generated F1 hybrids between two biotypes and found that symbiont density and immune suppression are both intermediate in hybrids. We suggest that in this system, Regiella symbionts are suppressing aphid immune mechanisms to increase their density, but that some hosts have adapted to prevent immune suppression in order to control symbiont numbers. The specific immune mechanisms suppressed by Regiella have been previously demonstrated to combat pathogens in aphids, and thus this work highlights the immune system’s complex dual role in interacting with both beneficial and harmful microbes. A uthor S ummary Heritable microbes are found in most insects including agriculturally and medically relevant pests. Explaining the variation in the distribution and abundance of symbionts in natural populations is critical to understanding these interactions. This work contributes to our mechanistic understanding of an important model of host-microbe symbiosis and suggests more broadly that variation in insect immune responses plays a role in intraspecific variation in host-symbiont interactions. Our work also suggests that antagonistic coevolution can play a role in host-microbe interactions even when microbes are transmitted vertically and provide a clear benefit to their hosts." @default.
• W3112868319 created "2020-12-21" @default.
• W3112868319 creator A5000468687 @default.
• W3112868319 creator A5007419472 @default.
• W3112868319 creator A5027675403 @default.
• W3112868319 creator A5070465184 @default.
• W3112868319 date "2020-12-18" @default.
• W3112868319 modified "2023-09-23" @default.
• W3112868319 title "Intraspecific variation in immune gene expression and heritable symbiont density" @default.
• W3112868319 cites W1592352451 @default.
• W3112868319 cites W1969157447 @default.
• W3112868319 cites W1970087350 @default.
• W3112868319 cites W1972531302 @default.
• W3112868319 cites W1973852760 @default.
• W3112868319 cites W1974314512 @default.
• W3112868319 cites W1979655623 @default.
• W3112868319 cites W1984643976 @default.
• W3112868319 cites W1986068618 @default.
• W3112868319 cites W1988406367 @default.
• W3112868319 cites W2002213182 @default.
• W3112868319 cites W2005196292 @default.
• W3112868319 cites W2008823848 @default.
• W3112868319 cites W2015088566 @default.
• W3112868319 cites W2026415696 @default.
• W3112868319 cites W2030206566 @default.
• W3112868319 cites W2033019844 @default.
• W3112868319 cites W2041301813 @default.
• W3112868319 cites W2047123551 @default.
• W3112868319 cites W2067981696 @default.
• W3112868319 cites W2074526322 @default.
• W3112868319 cites W2081236981 @default.
• W3112868319 cites W2084192230 @default.
• W3112868319 cites W2099490952 @default.
• W3112868319 cites W2099762535 @default.
• W3112868319 cites W2099806610 @default.
• W3112868319 cites W2104377574 @default.
• W3112868319 cites W2104991820 @default.
• W3112868319 cites W2108375187 @default.
• W3112868319 cites W2108466836 @default.
• W3112868319 cites W2109721710 @default.
• W3112868319 cites W2111441915 @default.
• W3112868319 cites W2113730339 @default.
• W3112868319 cites W2113885504 @default.
• W3112868319 cites W2118059471 @default.
• W3112868319 cites W2131739841 @default.
• W3112868319 cites W2134526812 @default.
• W3112868319 cites W2140729960 @default.
• W3112868319 cites W2146383080 @default.
• W3112868319 cites W2148137692 @default.
• W3112868319 cites W2150570211 @default.
• W3112868319 cites W2151731450 @default.
• W3112868319 cites W2154626064 @default.
• W3112868319 cites W2164445657 @default.
• W3112868319 cites W2168773255 @default.
• W3112868319 cites W2169408296 @default.
• W3112868319 cites W2193271668 @default.
• W3112868319 cites W2292127099 @default.
• W3112868319 cites W2345370461 @default.
• W3112868319 cites W2513719163 @default.
• W3112868319 cites W2541704780 @default.
• W3112868319 cites W2587994971 @default.
• W3112868319 cites W2594551290 @default.
• W3112868319 cites W2618191240 @default.
• W3112868319 cites W2765596610 @default.
• W3112868319 cites W2783557863 @default.
• W3112868319 cites W2804484743 @default.
• W3112868319 cites W2805773994 @default.
• W3112868319 cites W2889724756 @default.
• W3112868319 cites W2948756715 @default.
• W3112868319 cites W2951796795 @default.
• W3112868319 cites W2969981729 @default.
• W3112868319 cites W2979283958 @default.
• W3112868319 cites W2980749278 @default.
• W3112868319 cites W2999643990 @default.
• W3112868319 cites W3010030584 @default.
• W3112868319 cites W3011497109 @default.
• W3112868319 cites W3092628941 @default.
• W3112868319 cites W3096282572 @default.
• W3112868319 cites W769333041 @default.
• W3112868319 doi "https://doi.org/10.1101/2020.12.17.420083" @default.
• W3112868319 hasPublicationYear "2020" @default.
• W3112868319 type Work @default.
• W3112868319 sameAs 3112868319 @default.
• W3112868319 citedByCount "2" @default.
• W3112868319 countsByYear W31128683192021 @default.
• W3112868319 crossrefType "posted-content" @default.
• W3112868319 hasAuthorship W3112868319A5000468687 @default.
• W3112868319 hasAuthorship W3112868319A5007419472 @default.
• W3112868319 hasAuthorship W3112868319A5027675403 @default.
• W3112868319 hasAuthorship W3112868319A5070465184 @default.
• W3112868319 hasBestOaLocation W31128683191 @default.
• W3112868319 hasConcept C104317684 @default.
• W3112868319 hasConcept C126831891 @default.
• W3112868319 hasConcept C131892835 @default.
• W3112868319 hasConcept C166703698 @default.
• W3112868319 hasConcept C191942190 @default.
• W3112868319 hasConcept C22508944 @default.
• W3112868319 hasConcept C2775976403 @default.
• W3112868319 hasConcept C2776385806 @default.
• W3112868319 hasConcept C2776988988 @default.

• next