Matches in SemOpenAlex for { <https://semopenalex.org/work/W3112912472> ?p ?o ?g. }
- W3112912472 endingPage "3787" @default.
- W3112912472 startingPage "3787" @default.
- W3112912472 abstract "Patients with pancreatic ductal adenocarcinoma (PDAC) suffer debilitating and deadly weight loss, known as cachexia. Development of therapies requires biomarkers to diagnose, and monitor cachexia; however, no such markers are in use. Via Somascan, we measured ~1300 plasma proteins in 30 patients with PDAC vs. 11 controls. We found 60 proteins specific to local PDAC, 46 to metastatic, and 67 to presence of >5% cancer weight loss (FC ≥ |1.5|, p ≤ 0.05). Six were common for cancer stage (Up: GDF15, TIMP1, IL1RL1; Down: CCL22, APP, CLEC1B). Four were common for local/cachexia (C1R, PRKCG, ELANE, SOST: all oppositely regulated) and four for metastatic/cachexia (SERPINA6, PDGFRA, PRSS2, PRSS1: all consistently changed), suggesting that stage and cachexia status might be molecularly separable. We found 71 proteins that correlated with cachexia severity via weight loss grade, weight loss, skeletal muscle index and radiodensity (r ≥ |0.50|, p ≤ 0.05), including some known cachexia mediators/markers (LEP, MSTN, ALB) as well as novel proteins (e.g., LYVE1, C7, F2). Pathway, correlation, and upstream regulator analyses identified known (e.g., IL6, proteosome, mitochondrial dysfunction) and novel (e.g., Wnt signaling, NK cells) mechanisms. Overall, this study affords a basis for validation and provides insights into the processes underpinning cancer cachexia." @default.
- W3112912472 created "2020-12-21" @default.
- W3112912472 creator A5000373545 @default.
- W3112912472 creator A5011938575 @default.
- W3112912472 creator A5020303401 @default.
- W3112912472 creator A5021964432 @default.
- W3112912472 creator A5046800626 @default.
- W3112912472 creator A5060412535 @default.
- W3112912472 creator A5062765378 @default.
- W3112912472 creator A5066744991 @default.
- W3112912472 creator A5091389881 @default.
- W3112912472 date "2020-12-15" @default.
- W3112912472 modified "2023-10-15" @default.
- W3112912472 title "Identification of Potential Serum Protein Biomarkers and Pathways for Pancreatic Cancer Cachexia Using an Aptamer-Based Discovery Platform" @default.
- W3112912472 cites W1556530806 @default.
- W3112912472 cites W1831636259 @default.
- W3112912472 cites W1951855672 @default.
- W3112912472 cites W1962551563 @default.
- W3112912472 cites W1966206741 @default.
- W3112912472 cites W1978420586 @default.
- W3112912472 cites W1979243593 @default.
- W3112912472 cites W1981969796 @default.
- W3112912472 cites W1983660080 @default.
- W3112912472 cites W2002356152 @default.
- W3112912472 cites W2007617653 @default.
- W3112912472 cites W2020950228 @default.
- W3112912472 cites W2062360233 @default.
- W3112912472 cites W2066356596 @default.
- W3112912472 cites W2071088250 @default.
- W3112912472 cites W2074931217 @default.
- W3112912472 cites W2076365499 @default.
- W3112912472 cites W2085510141 @default.
- W3112912472 cites W2106994385 @default.
- W3112912472 cites W2107026277 @default.
- W3112912472 cites W2107483221 @default.
- W3112912472 cites W2108063882 @default.
- W3112912472 cites W2118558111 @default.
- W3112912472 cites W2121911732 @default.
- W3112912472 cites W2126792732 @default.
- W3112912472 cites W2127424726 @default.
- W3112912472 cites W2135778628 @default.
- W3112912472 cites W2136271461 @default.
- W3112912472 cites W2140937639 @default.
- W3112912472 cites W2145280166 @default.
- W3112912472 cites W2255388447 @default.
- W3112912472 cites W2268856907 @default.
- W3112912472 cites W2299393310 @default.
- W3112912472 cites W2316349176 @default.
- W3112912472 cites W2338333451 @default.
- W3112912472 cites W2345885627 @default.
- W3112912472 cites W2465901264 @default.
- W3112912472 cites W2514031291 @default.
- W3112912472 cites W2514615766 @default.
- W3112912472 cites W2557277725 @default.
- W3112912472 cites W2557454602 @default.
- W3112912472 cites W2570744073 @default.
- W3112912472 cites W2572423515 @default.
- W3112912472 cites W2573888447 @default.
- W3112912472 cites W2587398364 @default.
- W3112912472 cites W2589061996 @default.
- W3112912472 cites W2658952216 @default.
- W3112912472 cites W2747686805 @default.
- W3112912472 cites W2755616372 @default.
- W3112912472 cites W2771907223 @default.
- W3112912472 cites W2784374589 @default.
- W3112912472 cites W2789151443 @default.
- W3112912472 cites W2789456124 @default.
- W3112912472 cites W2799467895 @default.
- W3112912472 cites W2799544540 @default.
- W3112912472 cites W2805929522 @default.
- W3112912472 cites W2815133411 @default.
- W3112912472 cites W2865124547 @default.
- W3112912472 cites W2883614888 @default.
- W3112912472 cites W2895170266 @default.
- W3112912472 cites W2901603287 @default.
- W3112912472 cites W2925589217 @default.
- W3112912472 cites W2943003827 @default.
- W3112912472 cites W2944888496 @default.
- W3112912472 cites W2945809924 @default.
- W3112912472 cites W2958857500 @default.
- W3112912472 cites W2963815568 @default.
- W3112912472 cites W2964731712 @default.
- W3112912472 cites W2976760921 @default.
- W3112912472 cites W2980572764 @default.
- W3112912472 cites W2981899099 @default.
- W3112912472 cites W2991460539 @default.
- W3112912472 cites W2994160326 @default.
- W3112912472 cites W2995984299 @default.
- W3112912472 cites W3002603467 @default.
- W3112912472 cites W3004679402 @default.
- W3112912472 cites W3008104734 @default.
- W3112912472 cites W3017552499 @default.
- W3112912472 cites W3019666467 @default.
- W3112912472 cites W3022820931 @default.
- W3112912472 cites W3028453792 @default.
- W3112912472 cites W3034638495 @default.
- W3112912472 cites W3041625692 @default.
- W3112912472 cites W3042175018 @default.