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- W3112933822 abstract "Abstract Abnormal coagulation parameters have been explored in a significant number of severe COVID-19 patients, linked to poor prognosis and increased risk of organ failure. Here, to uncover the potential abnormalities in coagulation pathways, we analyzed the RNA-seq data (GEO147507) obtained from the treatment of three pulmonary epithelial cell lines with SARS-CoV-2. The significant differentially expressed genes (DEGs) were subjected to Enrichr database for KEGG pathway enrichment analysis and gene ontology (GO) functional annotation. The STRING database was used to generate PPI networks for identified DEGs. We found three upregulated procoagulant genes (SERPINE1, SERPINA5, and SERPINB2) belong to the serine protease inhibitor (serpin) superfamily that inhibit tissue plasminogen activator (t-PA) and urokinase plasminogen activator (u-PA) in the fibrinolysis process. In conclusion, we suggest the fibrinolysis process, especially the blockage of t-PA and u-PA inhibitors, a potential target for more study in treating coagulopathy in severe COVID-19 cases." @default.
- W3112933822 created "2020-12-21" @default.
- W3112933822 creator A5027181116 @default.
- W3112933822 creator A5072881408 @default.
- W3112933822 date "2020-12-07" @default.
- W3112933822 modified "2023-09-27" @default.
- W3112933822 title "Identification of potential coagulation pathway abnormalities in SARS-Cov-2 infection; insights from bioinformatics analysis" @default.
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- W3112933822 doi "https://doi.org/10.1101/2020.12.07.414631" @default.
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