Matches in SemOpenAlex for { <https://semopenalex.org/work/W3112934233> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W3112934233 abstract "Due to the lack of markers (ER, PR, and HER-2/Neu) for the molecular-targeted therapies triple-negative breast cancer (TNBC) is more challenging than other subtypes of breast cancer. Moreover, the conventional chemotherapeutic agents are still the mainstay of most therapeutic protocols and eventually turn into a refractory drug-resistance , hence, more efficient therapeutic regimens are urgently required. The present study aimed to elucidate the effects of PU-H71 combined with DHEA on triple-negative breast cancer cell line MDA-MB-231 and to assess the synergy using the Chou-Talalay method. The combined therapy controlled the expression of an array of antioxidants and metabolizing enzymes, leading to the induction of oxidative stress which in turn induced apoptotic cell death. Our results indicated that the combined treatment with PU-H71 and DHEA exerts a synergistic anti-tumor effect on MDA-MB-231 triple-negative breast cancer cell line." @default.
- W3112934233 created "2020-12-21" @default.
- W3112934233 creator A5012172467 @default.
- W3112934233 creator A5017393050 @default.
- W3112934233 creator A5026466501 @default.
- W3112934233 creator A5029294368 @default.
- W3112934233 creator A5039816985 @default.
- W3112934233 creator A5079645489 @default.
- W3112934233 creator A5083072701 @default.
- W3112934233 date "2020-12-15" @default.
- W3112934233 modified "2023-10-16" @default.
- W3112934233 title "Heat shock protein 90α inhibitor, PU-H71 in combination with DHEA promoting apoptosis in triple-negative breast cancer cell line MDA-MB-231" @default.
- W3112934233 doi "https://doi.org/10.18388/abp.2020_5418" @default.
- W3112934233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33319549" @default.
- W3112934233 hasPublicationYear "2020" @default.
- W3112934233 type Work @default.
- W3112934233 sameAs 3112934233 @default.
- W3112934233 citedByCount "0" @default.
- W3112934233 crossrefType "journal-article" @default.
- W3112934233 hasAuthorship W3112934233A5012172467 @default.
- W3112934233 hasAuthorship W3112934233A5017393050 @default.
- W3112934233 hasAuthorship W3112934233A5026466501 @default.
- W3112934233 hasAuthorship W3112934233A5029294368 @default.
- W3112934233 hasAuthorship W3112934233A5039816985 @default.
- W3112934233 hasAuthorship W3112934233A5079645489 @default.
- W3112934233 hasAuthorship W3112934233A5083072701 @default.
- W3112934233 hasBestOaLocation W31129342331 @default.
- W3112934233 hasConcept C121608353 @default.
- W3112934233 hasConcept C126322002 @default.
- W3112934233 hasConcept C143998085 @default.
- W3112934233 hasConcept C185592680 @default.
- W3112934233 hasConcept C190283241 @default.
- W3112934233 hasConcept C2780110267 @default.
- W3112934233 hasConcept C502942594 @default.
- W3112934233 hasConcept C530470458 @default.
- W3112934233 hasConcept C55493867 @default.
- W3112934233 hasConcept C71924100 @default.
- W3112934233 hasConcept C98274493 @default.
- W3112934233 hasConceptScore W3112934233C121608353 @default.
- W3112934233 hasConceptScore W3112934233C126322002 @default.
- W3112934233 hasConceptScore W3112934233C143998085 @default.
- W3112934233 hasConceptScore W3112934233C185592680 @default.
- W3112934233 hasConceptScore W3112934233C190283241 @default.
- W3112934233 hasConceptScore W3112934233C2780110267 @default.
- W3112934233 hasConceptScore W3112934233C502942594 @default.
- W3112934233 hasConceptScore W3112934233C530470458 @default.
- W3112934233 hasConceptScore W3112934233C55493867 @default.
- W3112934233 hasConceptScore W3112934233C71924100 @default.
- W3112934233 hasConceptScore W3112934233C98274493 @default.
- W3112934233 hasLocation W31129342331 @default.
- W3112934233 hasOpenAccess W3112934233 @default.
- W3112934233 hasPrimaryLocation W31129342331 @default.
- W3112934233 hasRelatedWork W1966181922 @default.
- W3112934233 hasRelatedWork W1999292713 @default.
- W3112934233 hasRelatedWork W2050936961 @default.
- W3112934233 hasRelatedWork W2101673433 @default.
- W3112934233 hasRelatedWork W2317787856 @default.
- W3112934233 hasRelatedWork W2366029130 @default.
- W3112934233 hasRelatedWork W2376078656 @default.
- W3112934233 hasRelatedWork W2554176272 @default.
- W3112934233 hasRelatedWork W3005028195 @default.
- W3112934233 hasRelatedWork W80971072 @default.
- W3112934233 isParatext "false" @default.
- W3112934233 isRetracted "false" @default.
- W3112934233 magId "3112934233" @default.
- W3112934233 workType "article" @default.