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- W3112951190 abstract "Unveiling the protective immune response to visceral leishmaniasis is critical for a rational design of vaccines aimed at reducing the impact caused by this fatal, if left untreated, vector-borne disease. In this study we sought to determine the role of the basic leucine zipper transcription factor ATF-like 3 (Batf3) in the evolution of infection with Leishmania infantum , the causative agent of human visceral leishmaniasis in the Mediterranean Basin and Latin America. For that, Batf3-deficient mice in C57BL/6 background were infected with an L. infantum strain expressing the luciferase gene. Bioluminescent imaging, as well as in vitro parasite titration, demonstrated that Batf3-deficient mice were unable to control hepatic parasitosis as opposed to wild-type C57BL/6 mice. The impaired microbicide capacities of L. infantum -infected macrophages from Batf3-deficient mice mainly correlated with a reduction of parasite-specific IFN-γ production. Our results reinforce the implication of Batf3 in the generation of type 1 immunity against infectious diseases." @default.
- W3112951190 created "2020-12-21" @default.
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- W3112951190 date "2020-12-10" @default.
- W3112951190 modified "2023-10-14" @default.
- W3112951190 title "Resistance to Experimental Visceral Leishmaniasis in Mice Infected With Leishmania infantum Requires Batf3" @default.
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- W3112951190 doi "https://doi.org/10.3389/fimmu.2020.590934" @default.
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