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• W3112966429 abstract "Ganoderma lucidum spores (GLS) exhibit disease prevention properties, but no study has been carried out on the anti-diabetic cardiomyopathy property of GLS. The aim of this study was to evaluate the hyperglycemia-mediated cardiomyopathy protection and mechanisms of GLS in streptozotocin (STZ)induced diabetic rats.Male SD rats were randomly divided into three groups. Two groups were given STZ (50 mg/kg, i.p.) treatment and when their fasting plasma glucose was above 16.7 mmol/L, among them, one group was given placebo, as diabetic group, and another group was given GLS (300 mg/kg) treatment. The group without STZ treatment was given placebo as a control group. The experiment lasted 70 days. The histology of myocardium and biomarkers of antioxidants, myocardial injury, pro-inflammatory cytokines, pro-apoptotic proteins and phosphorylation of key proteins in PI3K/AKT pathway were assessed.Biochemical analysis showed that GLS treatment significantly reduced the blood glucose (-20.3%) and triglyceride (-20.4%) levels compared to diabetic group without treatment. GLS treatment decreased the content of MDA (-25.6%) and activity of lactate dehydrogenase (-18.9%) but increased the activity of GSH-Px (65.4%). Western blot analysis showed that GLS treatment reduced the expression of both alpha-smooth muscle actin and brain natriuretic peptide. Histological analysis on the cardiac tissue micrographs showed that GLS treatment reduced collagen fibrosis and glycogen reactivity in myocardium. Both Western blot and immunohistochemistry analyses showed that GLS treatment decreased the expression levels of pro-inflammatory factors (cytokines IL-1β, and TNF-α) as well as apoptosis regulatory proteins (Bax, caspase-3 and -9), but increased Bcl-2. Moreover, GLS treatment significantly increased the phosphorylation of key proteins involved in PI3K/AKT pathway, eg, p-AKT p-PI3K and mTOR.The results indicated that GLS treatment alleviates diabetic cardiomyopathy by reducing hyperglycemia, oxidative stress, inflammation, apoptosis and further attenuating the fibrosis and myocardial dysfunction induced by STZ through stimulation of the PI3K/Akt/mTOR signaling pathway." @default.
• W3112966429 created "2020-12-21" @default.
• W3112966429 creator A5027475033 @default.
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• W3112966429 date "2020-12-01" @default.
• W3112966429 modified "2023-10-12" @default.
• W3112966429 title "<p>Effect and Mechanism of <em>Ganoderma lucidum</em> Spores on Alleviation of Diabetic Cardiomyopathy in a Pilot in vivo Study</p>" @default.
• W3112966429 cites W130389769 @default.
• W3112966429 cites W1519919074 @default.
• W3112966429 cites W1538255785 @default.
• W3112966429 cites W1839299407 @default.
• W3112966429 cites W1919988710 @default.
• W3112966429 cites W1971710954 @default.
• W3112966429 cites W1976747848 @default.
• W3112966429 cites W1979995768 @default.
• W3112966429 cites W1985489730 @default.
• W3112966429 cites W1990800883 @default.
• W3112966429 cites W1995269354 @default.
• W3112966429 cites W1996376927 @default.
• W3112966429 cites W1998300009 @default.
• W3112966429 cites W2000949003 @default.
• W3112966429 cites W2003068164 @default.
• W3112966429 cites W2008757142 @default.
• W3112966429 cites W2009855619 @default.
• W3112966429 cites W2014316079 @default.
• W3112966429 cites W2014877928 @default.
• W3112966429 cites W2016677731 @default.
• W3112966429 cites W2016786240 @default.
• W3112966429 cites W2016818962 @default.
• W3112966429 cites W2017148061 @default.
• W3112966429 cites W2019987942 @default.
• W3112966429 cites W2026071606 @default.
• W3112966429 cites W2027730134 @default.
• W3112966429 cites W2028097684 @default.
• W3112966429 cites W2036317083 @default.
• W3112966429 cites W2039136120 @default.
• W3112966429 cites W2044550212 @default.
• W3112966429 cites W2045824542 @default.
• W3112966429 cites W2054655581 @default.
• W3112966429 cites W2056677635 @default.
• W3112966429 cites W2061697233 @default.
• W3112966429 cites W2067651150 @default.
• W3112966429 cites W2067778098 @default.
• W3112966429 cites W2083882121 @default.
• W3112966429 cites W2085871805 @default.
• W3112966429 cites W2087750804 @default.
• W3112966429 cites W2091997040 @default.
• W3112966429 cites W2096548382 @default.
• W3112966429 cites W2099626067 @default.
• W3112966429 cites W2101808557 @default.
• W3112966429 cites W2102797065 @default.
• W3112966429 cites W2103952982 @default.
• W3112966429 cites W2104044832 @default.
• W3112966429 cites W2109122379 @default.
• W3112966429 cites W2114375201 @default.
• W3112966429 cites W2124273309 @default.
• W3112966429 cites W2127321192 @default.
• W3112966429 cites W2129242642 @default.
• W3112966429 cites W2134259348 @default.
• W3112966429 cites W2136147886 @default.
• W3112966429 cites W2136304944 @default.
• W3112966429 cites W2143237896 @default.
• W3112966429 cites W2145592978 @default.
• W3112966429 cites W2151485054 @default.
• W3112966429 cites W2156138194 @default.
• W3112966429 cites W2168129192 @default.
• W3112966429 cites W2168967151 @default.
• W3112966429 cites W2333346430 @default.
• W3112966429 cites W2350366672 @default.
• W3112966429 cites W2469752403 @default.
• W3112966429 cites W2510435007 @default.
• W3112966429 cites W2741151004 @default.
• W3112966429 cites W2756104041 @default.
• W3112966429 cites W2758068989 @default.
• W3112966429 cites W2765890536 @default.
• W3112966429 cites W2778234697 @default.
• W3112966429 cites W2791011305 @default.
• W3112966429 cites W2791897308 @default.
• W3112966429 cites W2810977975 @default.
• W3112966429 cites W2909953711 @default.
• W3112966429 cites W2923081711 @default.
• W3112966429 cites W2979069276 @default.
• W3112966429 cites W3044735048 @default.
• W3112966429 cites W4243186398 @default.
• W3112966429 cites W616481914 @default.
• W3112966429 doi "https://doi.org/10.2147/dmso.s281527" @default.
• W3112966429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7736836" @default.
• W3112966429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33335409" @default.
• W3112966429 hasPublicationYear "2020" @default.
• W3112966429 type Work @default.

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