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- W3112993770 abstract "Introduction. Diabetes mellitus (DM) in children - a chronic pathology that requiresconstant medical attention due to the labile course, the complexity of the treatment, atendency to developing autoimmune processes, complications and disability.Objective: to identify predictors of controlled course of autoimmune diabetes inchildren for predicting its occurrence.Materials and methods: among 100 children with first diagnosed type 1 diabetesaged from 1 to 18 years was confirmed autoimmune diabetes in 98 children bydetermining the level of antibodies to glutamic acid decarboxylase, tyrosinephosphatase (islet antigen-2), zinc transporters, by enzyme immunoassay (ELISA,«Euroimmun»). Using sequential analysis of Wald, was analyzed 100 clinical -immunological, molecular - genetic, instrumental - diagnostic parametersdetermining relative risk (RR) and diagnostic coefficient (DC) in patients with uncontrolled (study group, n=23) and controlled course (control group, n=31) ofautoimmune diabetes.Results. Predictors of controlled course of autoimmune diabetes in children wereselected 14 factors sufficiently informative prognostic significance (I≥0,5), which aresuitable to use in clinical practice: the level of glycated hemoglobin less than 9%after 1 year of observation (I=5.4), transferred flu 1 year before debut of DM(I=1.58), no increase in antibodies to glutamic acid decarboxylase (I=1.2), alanineaminotransferase level more than 39.3 U/l (I=1.18), age of manifestation of thedisease 4-6 years (I=1.02), alkaline phosphatase level less than 328 U/l (I=0.76),maximum glycemia less than 23 mmol/l (I=0.64), weight at birth less than 4 kg(I=0.63), the level of urea less than 4.3 mmol/L in the blood (I=0.61), relatedautoimmune diseases (I=0.56), concomitant cardiovascular pathology (I=0.56),hypoproteinemia less than 60 g/dL (I=0.55), observance of hourly diet in the firstyear of life (I=0.54), the absence of glycosuria (I=0.54).Conclusion: to improve the quality of diagnosis, prognosis and personalizedtreatment of autoimmune diabetes mellitus, especially in patients with first diagnoseddisease, is necessary to define specific autoantibodies against islet apparatus of thepancreas, a, namely, the study of the level of antibodies to glutamic aciddecarboxylase." @default.
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- W3112993770 date "2020-01-01" @default.
- W3112993770 modified "2023-09-23" @default.
- W3112993770 title "Stratification of controlled course of autoimmune diabetes mellitus as a low-level inflammation in children" @default.
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