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- W3113010231 endingPage "344" @default.
- W3113010231 startingPage "344" @default.
- W3113010231 abstract "Chemotherapy-related cardiac dysfunction, also known as cardiotoxicity, is a group of drug-related adverse events negatively affecting myocardial structure and functions in patients who received chemotherapy for cancer treatment. Clinical manifestations can vary from life-threatening arrythmias to chronic conditions, such as heart failure or hypertension, which dramatically reduce quality of life of cancer survivors. Standard chemotherapy exerts its toxic effect mainly by inducing oxidative stress and genomic instability, while new targeted therapies work by interfering with signaling pathways important not only in cancer cells but also in myocytes. For example, Bruton’s tyrosine kinase (BTK) inhibitors interfere with class I phosphoinositide 3-kinase isoforms involved in cardiac hypertrophy, contractility, and regulation of various channel forming proteins; thus, off-target effects of BTK inhibitors are associated with increased frequency of arrhythmias, such as atrial fibrillation, compared to standard chemotherapy. In this review, we summarize current knowledge of cardiotoxic effects of targeted therapies used in hematology." @default.
- W3113010231 created "2020-12-21" @default.
- W3113010231 creator A5026122857 @default.
- W3113010231 creator A5037687084 @default.
- W3113010231 creator A5085584750 @default.
- W3113010231 date "2020-12-11" @default.
- W3113010231 modified "2023-10-17" @default.
- W3113010231 title "Cardiotoxicity of Novel Targeted Hematological Therapies" @default.
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