FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113014281> ?p ?o ?g. }

• W3113014281 endingPage "5843" @default.
• W3113014281 startingPage "5843" @default.
• W3113014281 abstract "In this study, we propose lactucopicrin (LCTP), a natural sesquiterpene lactone from Lactucavirosa, as a molecule able to control the growth of glioblastoma continuous cell line U87Mg. The IC50 of U87Mg against LCTP revealed a strong cytotoxic effect. Daily administration of LCTP showed a dose and time-dependent reduction of GBM cell growth and viability, also confirmed by inhibition of clonogenic potential and mobility of U87Mg cells. LCTP activated autophagy in U87Mg cells and decreased the phosphorylation of proliferative signals pAKT and pERK. LCTP also induced the cell cycle arrest in G2/M phase, confirmed by decrease of CDK2 protein and increase of p53 and p21. LCTP stimulated apoptosis as evidenced by reduction of procaspase 6 and the increase of the cleaved/full-length PARP ratio. The pre-treatment of U87Mg cells with ROS scavenger N-acetylcysteine (NAC), which reversed its cytotoxic effect, showed the involvement of LCTP in oxidative stress. Finally, LCTP strongly enhanced the sensitivity of U87Mg cells to canonical therapy Temozolomide (TMZ) and synergized with this drug. Altogether, the growth inhibition of U87Mg GBM cells induced by LCTP is the result of several synergic mechanisms, which makes LCTP a promising adjuvant therapy for this complex pathology." @default.
• W3113014281 created "2020-12-21" @default.
• W3113014281 creator A5037259751 @default.
• W3113014281 creator A5037481871 @default.
• W3113014281 creator A5055677852 @default.
• W3113014281 creator A5063688819 @default.
• W3113014281 creator A5065962624 @default.
• W3113014281 creator A5089427177 @default.
• W3113014281 date "2020-12-10" @default.
• W3113014281 modified "2023-10-03" @default.
• W3113014281 title "Implication of Lactucopicrin in Autophagy, Cell Cycle Arrest and Oxidative Stress to Inhibit U87Mg Glioblastoma Cell Growth" @default.
• W3113014281 cites W1536266814 @default.
• W3113014281 cites W1623947966 @default.
• W3113014281 cites W1969757297 @default.
• W3113014281 cites W1980509967 @default.
• W3113014281 cites W2019154144 @default.
• W3113014281 cites W2019167849 @default.
• W3113014281 cites W2024386344 @default.
• W3113014281 cites W2027314483 @default.
• W3113014281 cites W2043029667 @default.
• W3113014281 cites W2055475004 @default.
• W3113014281 cites W2057397500 @default.
• W3113014281 cites W2085827306 @default.
• W3113014281 cites W2095518262 @default.
• W3113014281 cites W2096435523 @default.
• W3113014281 cites W2121858124 @default.
• W3113014281 cites W2128450526 @default.
• W3113014281 cites W2133133765 @default.
• W3113014281 cites W2158681922 @default.
• W3113014281 cites W2165425627 @default.
• W3113014281 cites W2257494961 @default.
• W3113014281 cites W2626824598 @default.
• W3113014281 cites W2734770420 @default.
• W3113014281 cites W2754097799 @default.
• W3113014281 cites W2767720032 @default.
• W3113014281 cites W2790403919 @default.
• W3113014281 cites W2795652653 @default.
• W3113014281 cites W2799546960 @default.
• W3113014281 cites W2809828975 @default.
• W3113014281 cites W2886417282 @default.
• W3113014281 cites W2890770499 @default.
• W3113014281 cites W2892791046 @default.
• W3113014281 cites W2904638732 @default.
• W3113014281 cites W2989310374 @default.
• W3113014281 cites W4206052290 @default.
• W3113014281 cites W4232678241 @default.
• W3113014281 doi "https://doi.org/10.3390/molecules25245843" @default.
• W3113014281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7764785" @default.
• W3113014281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33322048" @default.
• W3113014281 hasPublicationYear "2020" @default.
• W3113014281 type Work @default.
• W3113014281 sameAs 3113014281 @default.
• W3113014281 citedByCount "9" @default.
• W3113014281 countsByYear W31130142812021 @default.
• W3113014281 countsByYear W31130142812022 @default.
• W3113014281 countsByYear W31130142812023 @default.
• W3113014281 crossrefType "journal-article" @default.
• W3113014281 hasAuthorship W3113014281A5037259751 @default.
• W3113014281 hasAuthorship W3113014281A5037481871 @default.
• W3113014281 hasAuthorship W3113014281A5055677852 @default.
• W3113014281 hasAuthorship W3113014281A5063688819 @default.
• W3113014281 hasAuthorship W3113014281A5065962624 @default.
• W3113014281 hasAuthorship W3113014281A5089427177 @default.
• W3113014281 hasBestOaLocation W31130142811 @default.
• W3113014281 hasConcept C105696609 @default.
• W3113014281 hasConcept C117262875 @default.
• W3113014281 hasConcept C154317977 @default.
• W3113014281 hasConcept C185592680 @default.
• W3113014281 hasConcept C190283241 @default.
• W3113014281 hasConcept C202751555 @default.
• W3113014281 hasConcept C203522944 @default.
• W3113014281 hasConcept C2776151105 @default.
• W3113014281 hasConcept C2776194525 @default.
• W3113014281 hasConcept C2777389519 @default.
• W3113014281 hasConcept C2779707156 @default.
• W3113014281 hasConcept C29537977 @default.
• W3113014281 hasConcept C502942594 @default.
• W3113014281 hasConcept C53227056 @default.
• W3113014281 hasConcept C55493867 @default.
• W3113014281 hasConcept C62112901 @default.
• W3113014281 hasConcept C86803240 @default.
• W3113014281 hasConcept C95444343 @default.
• W3113014281 hasConcept C98274493 @default.
• W3113014281 hasConceptScore W3113014281C105696609 @default.
• W3113014281 hasConceptScore W3113014281C117262875 @default.
• W3113014281 hasConceptScore W3113014281C154317977 @default.
• W3113014281 hasConceptScore W3113014281C185592680 @default.
• W3113014281 hasConceptScore W3113014281C190283241 @default.
• W3113014281 hasConceptScore W3113014281C202751555 @default.
• W3113014281 hasConceptScore W3113014281C203522944 @default.
• W3113014281 hasConceptScore W3113014281C2776151105 @default.
• W3113014281 hasConceptScore W3113014281C2776194525 @default.
• W3113014281 hasConceptScore W3113014281C2777389519 @default.
• W3113014281 hasConceptScore W3113014281C2779707156 @default.
• W3113014281 hasConceptScore W3113014281C29537977 @default.
• W3113014281 hasConceptScore W3113014281C502942594 @default.
• W3113014281 hasConceptScore W3113014281C53227056 @default.
• W3113014281 hasConceptScore W3113014281C55493867 @default.

• next