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- W3113015795 abstract "Abstract Recent demonstrations of RNA–DNA chimeras (RDNA) enabling RNA and DNA replication, coupled with prebiotic co‐synthesis of deoxyribo‐ and ribo‐nucleotides, have resurrected the hypothesis of co‐emergence of RNA and DNA. As further support, we show that diamidophosphate (DAP) with 2‐aminoimidazole (amido)phosphorylates and oligomerizes deoxynucleosides to form DNA—under conditions similar to those of ribonucleosides. The pyrimidine deoxynucleoside 5′‐O‐amidophosphates are formed in good (≈60 %) yields. Intriguingly, the presence of pyrimidine deoxynucleos(t)ides increased the yields of purine deoxynucleotides (≈20 %). Concomitantly, oligomerization (≈18–31 %) is observed with predominantly 3′,5′‐phosphodiester DNA linkages, and some (<5 %) pyrophosphates. Combined with previous observations of DAP‐mediated chemistries and the constructive role of RDNA chimeras, the results reported here help set the stage for systematic investigation of a systems chemistry approach of RNA–DNA coevolution." @default.
- W3113015795 created "2020-12-21" @default.
- W3113015795 creator A5012295989 @default.
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- W3113015795 date "2021-03-30" @default.
- W3113015795 modified "2023-09-30" @default.
- W3113015795 title "Prebiotic Phosphorylation and Concomitant Oligomerization of Deoxynucleosides to form DNA" @default.
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- W3113015795 doi "https://doi.org/10.1002/anie.202015910" @default.
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