FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113019675> ?p ?o ?g. }

• W3113019675 endingPage "103167" @default.
• W3113019675 startingPage "103167" @default.
• W3113019675 abstract "Dolutegravir (DTG) is a preferred regimen for all people with HIV including pregnant women, but its effects on the fetus are not fully understood. Periconceptional exposure to DTG has been associated with increased rates of neural tube defects (NTDs), although it is unknown whether this is a causal relationship. This has led to uncertainty around the use of DTG in women of reproductive potential.Pregnant C57BL/6J mice were randomly allocated to control (water), 1x-DTG (2.5 mg/kg-peak plasma concentration ~3000 ng/ml - therapeutic level), or 5x-DTG (12.5 mg/kg-peak plasma concentration ~12,000 ng/ml - supratherapeutic level), once daily from gestational day 0.5 until sacrifice. DTG was administered with 50 mg/kg tenofovir+33.3 mg/kg emtricitabine. Fetal phenotypes were determined, and maternal and fetal folate levels were quantified by mass-spectrometry.352 litters (91 control, 150 1x-DTG, 111 5x-DTG) yielding 2776 fetuses (747 control, 1174 1x-DTG, 855 5x-DTG) were assessed. Litter size and viability rates were similar between groups. Fetal and placenta weights were lower in the 1x-DTG vs. control. Placental weight was higher in the 5x-DTG vs. control. Five NTDs were observed, all in the 1x-DTG group. Fetal defects, including microphthalmia, severe edema, and vascular/bleeding defects were more frequent in the 1x-DTG group. In contrast, defect rates in the 5x-DTG were similar to control. Fetal folate levels were similar between control and 1x-DTG, but were significantly higher in the 5x-DTG group.Our findings support a causal relationship of DTG at therapeutic doses with increased risk for fetal defects, including NTDs at a rate that is similar that reported in the Tsepamo study for women exposed to DTG-based ART from conception. The non-monotonic dose-response relationship between DTG and fetal anomalies could explain the previous lack of fetal toxicity findings from pre-clinical DTG studies. The fetal folate levels suggest that DTG is unlikely to be an inhibitor of folate uptake.This project has been funded with Federal funds from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN275201800001I." @default.
• W3113019675 created "2020-12-21" @default.
• W3113019675 creator A5004456740 @default.
• W3113019675 creator A5007029324 @default.
• W3113019675 creator A5008930321 @default.
• W3113019675 creator A5017205465 @default.
• W3113019675 creator A5030268212 @default.
• W3113019675 creator A5034081828 @default.
• W3113019675 creator A5039712117 @default.
• W3113019675 creator A5048893499 @default.
• W3113019675 creator A5053177280 @default.
• W3113019675 creator A5079441899 @default.
• W3113019675 creator A5083608116 @default.
• W3113019675 creator A5091593779 @default.
• W3113019675 date "2021-01-01" @default.
• W3113019675 modified "2023-10-15" @default.
• W3113019675 title "Dolutegravir in pregnant mice is associated with increased rates of fetal defects at therapeutic but not at supratherapeutic levels" @default.
• W3113019675 cites W1222186586 @default.
• W3113019675 cites W1991252317 @default.
• W3113019675 cites W2000259887 @default.
• W3113019675 cites W2004224047 @default.
• W3113019675 cites W2020458486 @default.
• W3113019675 cites W2027977341 @default.
• W3113019675 cites W2034147222 @default.
• W3113019675 cites W2040117889 @default.
• W3113019675 cites W2056974877 @default.
• W3113019675 cites W2097327668 @default.
• W3113019675 cites W2106462723 @default.
• W3113019675 cites W2116403786 @default.
• W3113019675 cites W2143431969 @default.
• W3113019675 cites W2160101621 @default.
• W3113019675 cites W2171988069 @default.
• W3113019675 cites W2600998502 @default.
• W3113019675 cites W2756096060 @default.
• W3113019675 cites W2770089211 @default.
• W3113019675 cites W2786157050 @default.
• W3113019675 cites W2789831831 @default.
• W3113019675 cites W2793088983 @default.
• W3113019675 cites W2800677865 @default.
• W3113019675 cites W2811505616 @default.
• W3113019675 cites W2883284210 @default.
• W3113019675 cites W2890057333 @default.
• W3113019675 cites W2890762658 @default.
• W3113019675 cites W2929920150 @default.
• W3113019675 cites W2933955404 @default.
• W3113019675 cites W2942276455 @default.
• W3113019675 cites W2949008366 @default.
• W3113019675 cites W2952168964 @default.
• W3113019675 cites W2955129433 @default.
• W3113019675 cites W2960767487 @default.
• W3113019675 cites W2963164305 @default.
• W3113019675 cites W2963200087 @default.
• W3113019675 cites W2964262294 @default.
• W3113019675 cites W2995932413 @default.
• W3113019675 cites W3013973848 @default.
• W3113019675 cites W3016857003 @default.
• W3113019675 cites W3021440785 @default.
• W3113019675 cites W3102058442 @default.
• W3113019675 cites W868534065 @default.
• W3113019675 doi "https://doi.org/10.1016/j.ebiom.2020.103167" @default.
• W3113019675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7753150" @default.
• W3113019675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33341441" @default.
• W3113019675 hasPublicationYear "2021" @default.
• W3113019675 type Work @default.
• W3113019675 sameAs 3113019675 @default.
• W3113019675 citedByCount "22" @default.
• W3113019675 countsByYear W31130196752021 @default.
• W3113019675 countsByYear W31130196752022 @default.
• W3113019675 countsByYear W31130196752023 @default.
• W3113019675 crossrefType "journal-article" @default.
• W3113019675 hasAuthorship W3113019675A5004456740 @default.
• W3113019675 hasAuthorship W3113019675A5007029324 @default.
• W3113019675 hasAuthorship W3113019675A5008930321 @default.
• W3113019675 hasAuthorship W3113019675A5017205465 @default.
• W3113019675 hasAuthorship W3113019675A5030268212 @default.
• W3113019675 hasAuthorship W3113019675A5034081828 @default.
• W3113019675 hasAuthorship W3113019675A5039712117 @default.
• W3113019675 hasAuthorship W3113019675A5048893499 @default.
• W3113019675 hasAuthorship W3113019675A5053177280 @default.
• W3113019675 hasAuthorship W3113019675A5079441899 @default.
• W3113019675 hasAuthorship W3113019675A5083608116 @default.
• W3113019675 hasAuthorship W3113019675A5091593779 @default.
• W3113019675 hasBestOaLocation W31130196751 @default.
• W3113019675 hasConcept C104317684 @default.
• W3113019675 hasConcept C126322002 @default.
• W3113019675 hasConcept C142462285 @default.
• W3113019675 hasConcept C16685009 @default.
• W3113019675 hasConcept C172680121 @default.
• W3113019675 hasConcept C185592680 @default.
• W3113019675 hasConcept C203014093 @default.
• W3113019675 hasConcept C2776953305 @default.
• W3113019675 hasConcept C2778085061 @default.
• W3113019675 hasConcept C2778376644 @default.
• W3113019675 hasConcept C2779234561 @default.
• W3113019675 hasConcept C2779429622 @default.
• W3113019675 hasConcept C2779502633 @default.
• W3113019675 hasConcept C2781413609 @default.
• W3113019675 hasConcept C2993143319 @default.

• next