FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113019899> ?p ?o ?g. }

• W3113019899 endingPage "68" @default.
• W3113019899 startingPage "60" @default.
• W3113019899 abstract "<b><i>Aims:</i></b> This study aimed to explore the new role of telomere length (TL) in the novel classification of type 2 diabetes mellitus (T2DM) patients driven by cluster analysis. <b><i>Materials and Methods:</i></b> A total of 541 T2DM patients were divided into 4 subgroups by <i>k</i>-means analysis: mild obesity-related diabetes (MOD), severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), and mild age-related diabetes (MARD). After patients with insufficient data were excluded, further analysis was conducted on 246 T2DM patients. The TL was detected using telomere restriction fragment, and the related diabetic indexes were also measured by clinical standard procedures. <b><i>Results:</i></b> The MARD group had significantly shorter TLs than the MOD and SIDD groups. Then, we subdivided all T2DM patients into the MARD and NONMARD groups, which included the MOD, SIDD, and SIRD groups. The TLs of the MARD group, associated with age, were discovered to be significantly shorter than those of the NONMARD group (<i>p</i> = 0.0012), and this difference in TL disappeared after metformin (<i>p</i> = 0.880) and acarbose treatment (<i>p</i> = 0.058). The linear analysis showed that metformin can more obviously reduce telomere shortening in the MARD group (<i>r</i> = 0.030, 95% CI 0.010–0.051,<i> p</i> = 0.004), and acarbose can more apparently promote telomere attrition in the SIRD group (<i>r</i> = –0.069, 95% CI –0.100 to –0.039, <i>p</i>&#x3c; 0.001) compared with other T2DM patients after adjusting for age and gender. <b><i>Conclusions:</i></b> The MARD group was found to have shorter TLs and benefit more from the antiaging effect of metformin than other T2DM. Shorter TLs were observed in the SIRD group after acarbose use." @default.
• W3113019899 created "2020-12-21" @default.
• W3113019899 creator A5052898732 @default.
• W3113019899 creator A5069505886 @default.
• W3113019899 creator A5074270758 @default.
• W3113019899 creator A5080283046 @default.
• W3113019899 creator A5080998212 @default.
• W3113019899 date "2020-12-15" @default.
• W3113019899 modified "2023-09-24" @default.
• W3113019899 title "The Association between Antidiabetic Agents and Leukocyte Telomere Length in the Novel Classification of Type 2 Diabetes Mellitus" @default.
• W3113019899 cites W1486293700 @default.
• W3113019899 cites W1984218790 @default.
• W3113019899 cites W2004216466 @default.
• W3113019899 cites W2004469517 @default.
• W3113019899 cites W2031475310 @default.
• W3113019899 cites W2033855112 @default.
• W3113019899 cites W2034838676 @default.
• W3113019899 cites W2043021712 @default.
• W3113019899 cites W2050594725 @default.
• W3113019899 cites W2053556250 @default.
• W3113019899 cites W2113899734 @default.
• W3113019899 cites W2145317285 @default.
• W3113019899 cites W2147991226 @default.
• W3113019899 cites W2162970447 @default.
• W3113019899 cites W2166514049 @default.
• W3113019899 cites W2167246619 @default.
• W3113019899 cites W2201157854 @default.
• W3113019899 cites W2272557320 @default.
• W3113019899 cites W2320360102 @default.
• W3113019899 cites W2422981416 @default.
• W3113019899 cites W2473725818 @default.
• W3113019899 cites W2481126756 @default.
• W3113019899 cites W2596624061 @default.
• W3113019899 cites W2742029199 @default.
• W3113019899 cites W2743743650 @default.
• W3113019899 cites W2765850530 @default.
• W3113019899 cites W2772758960 @default.
• W3113019899 cites W2790501791 @default.
• W3113019899 cites W2803005795 @default.
• W3113019899 cites W2890207510 @default.
• W3113019899 cites W2905259954 @default.
• W3113019899 cites W2913642221 @default.
• W3113019899 cites W2921707030 @default.
• W3113019899 cites W2951518977 @default.
• W3113019899 cites W2971100984 @default.
• W3113019899 cites W2974374436 @default.
• W3113019899 cites W2977880419 @default.
• W3113019899 cites W3003556279 @default.
• W3113019899 cites W3004823234 @default.
• W3113019899 cites W3019800544 @default.
• W3113019899 doi "https://doi.org/10.1159/000511362" @default.
• W3113019899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33321495" @default.
• W3113019899 hasPublicationYear "2020" @default.
• W3113019899 type Work @default.
• W3113019899 sameAs 3113019899 @default.
• W3113019899 citedByCount "5" @default.
• W3113019899 countsByYear W31130198992021 @default.
• W3113019899 countsByYear W31130198992022 @default.
• W3113019899 countsByYear W31130198992023 @default.
• W3113019899 crossrefType "journal-article" @default.
• W3113019899 hasAuthorship W3113019899A5052898732 @default.
• W3113019899 hasAuthorship W3113019899A5069505886 @default.
• W3113019899 hasAuthorship W3113019899A5074270758 @default.
• W3113019899 hasAuthorship W3113019899A5080283046 @default.
• W3113019899 hasAuthorship W3113019899A5080998212 @default.
• W3113019899 hasConcept C126322002 @default.
• W3113019899 hasConcept C134018914 @default.
• W3113019899 hasConcept C177336024 @default.
• W3113019899 hasConcept C2776617576 @default.
• W3113019899 hasConcept C2777180221 @default.
• W3113019899 hasConcept C2779306644 @default.
• W3113019899 hasConcept C2780323712 @default.
• W3113019899 hasConcept C2910068830 @default.
• W3113019899 hasConcept C552990157 @default.
• W3113019899 hasConcept C55493867 @default.
• W3113019899 hasConcept C555293320 @default.
• W3113019899 hasConcept C71924100 @default.
• W3113019899 hasConcept C86803240 @default.
• W3113019899 hasConceptScore W3113019899C126322002 @default.
• W3113019899 hasConceptScore W3113019899C134018914 @default.
• W3113019899 hasConceptScore W3113019899C177336024 @default.
• W3113019899 hasConceptScore W3113019899C2776617576 @default.
• W3113019899 hasConceptScore W3113019899C2777180221 @default.
• W3113019899 hasConceptScore W3113019899C2779306644 @default.
• W3113019899 hasConceptScore W3113019899C2780323712 @default.
• W3113019899 hasConceptScore W3113019899C2910068830 @default.
• W3113019899 hasConceptScore W3113019899C552990157 @default.
• W3113019899 hasConceptScore W3113019899C55493867 @default.
• W3113019899 hasConceptScore W3113019899C555293320 @default.
• W3113019899 hasConceptScore W3113019899C71924100 @default.
• W3113019899 hasConceptScore W3113019899C86803240 @default.
• W3113019899 hasIssue "1" @default.
• W3113019899 hasLocation W31130198991 @default.
• W3113019899 hasOpenAccess W3113019899 @default.
• W3113019899 hasPrimaryLocation W31130198991 @default.
• W3113019899 hasRelatedWork W1983641721 @default.
• W3113019899 hasRelatedWork W1996010611 @default.
• W3113019899 hasRelatedWork W2033313326 @default.

• next