FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113042016> ?p ?o ?g. }

• W3113042016 endingPage "304" @default.
• W3113042016 startingPage "280" @default.
• W3113042016 abstract "Nanotechnology involves the engineering of structures on a molecular level. Nanomedicine and nano-delivery systems have been designed to deliver therapeutic agents to a target site or organ in a controlled manner, maximizing efficacy while minimizing off-target effects of the therapeutic agent administered. In both reproductive medicine and obstetrics, developing innovative therapeutics is often tempered by fears of damage to the gamete, embryo or developing foetus or of negatively impacting a woman's reproductive potential. Thus, nanomedicine delivery systems may provide alternative targeted intervention strategies, treating the source of the disease and minimizing long-term consequences for the mother and/or her foetus.This review summarizes the current state of nanomedicine technology in reproductive medicine and obstetrics, including safety, potential applications, future directions and the hurdles for translation.A comprehensive electronic literature search of PubMed and Web of Science databases was performed to identify studies published in English up until February 2020. Relevant keywords were used to obtain information regarding use of nanoparticle technology in fertility and gene therapy, early pregnancy complications (ectopic pregnancy and gestational trophoblastic disease) and obstetric complications (preeclampsia, foetal growth restriction, preterm birth and gestational diabetes) and for selective treatment of the mother or foetus. Safety of specific nanoparticles to the gamete, embryo and foetus was also investigated.Pre-clinical research in the development of nanoparticle therapeutic delivery is being undertaken in many fields of reproductive medicine. Non-hormonal-targeted nanoparticle therapy for fibroids and endometriosis may provide fertility-sparing medical management. Delivery of interventions via nanotechnology provides opportunities for gene manipulation and delivery in mammalian gametes. Targeting cytotoxic treatments to early pregnancy tissue provides an alternative approach to manage ectopic pregnancies and gestational trophoblastic disease. In pregnancy, nanotherapeutic delivery offers options to stably deliver silencing RNA and microRNA inhibitors to the placenta to regulate gene expression, opening doors to novel genetic treatments for preeclampsia and foetal growth restriction. Restricting delivery of teratogenic drugs to the maternal compartment (such as warfarin) may reduce risks to the foetus. Alternatively, targeted delivery of drugs to the foetus (such as those to treat foetal arrythmias) may minimize side effects for the mother.We expect that further development of targeted therapies using nanoparticles in a reproductive setting has promise to eventually allow safe and directed treatments for conditions impacting the health and reproductive capacity of women and for the management of pregnancy and serious pregnancy complications." @default.
• W3113042016 created "2020-12-21" @default.
• W3113042016 creator A5019836429 @default.
• W3113042016 creator A5021918263 @default.
• W3113042016 creator A5044161059 @default.
• W3113042016 creator A5062361099 @default.
• W3113042016 creator A5081990591 @default.
• W3113042016 date "2020-12-06" @default.
• W3113042016 modified "2023-10-18" @default.
• W3113042016 title "Nanoparticles in pregnancy: the next frontier in reproductive therapeutics" @default.
• W3113042016 cites W1513717411 @default.
• W3113042016 cites W1517029702 @default.
• W3113042016 cites W1518898595 @default.
• W3113042016 cites W1543814382 @default.
• W3113042016 cites W1721689174 @default.
• W3113042016 cites W1749110650 @default.
• W3113042016 cites W1793124009 @default.
• W3113042016 cites W1812840031 @default.
• W3113042016 cites W1852891668 @default.
• W3113042016 cites W1854963518 @default.
• W3113042016 cites W1868158647 @default.
• W3113042016 cites W1896852452 @default.
• W3113042016 cites W1929513149 @default.
• W3113042016 cites W1954757690 @default.
• W3113042016 cites W1964748278 @default.
• W3113042016 cites W1965313332 @default.
• W3113042016 cites W1966042314 @default.
• W3113042016 cites W1966318343 @default.
• W3113042016 cites W1969018878 @default.
• W3113042016 cites W1970122977 @default.
• W3113042016 cites W1970366126 @default.
• W3113042016 cites W1971470501 @default.
• W3113042016 cites W1972203768 @default.
• W3113042016 cites W1974090429 @default.
• W3113042016 cites W1975058211 @default.
• W3113042016 cites W1975131013 @default.
• W3113042016 cites W1975160431 @default.
• W3113042016 cites W1975588119 @default.
• W3113042016 cites W1975755498 @default.
• W3113042016 cites W1975776673 @default.
• W3113042016 cites W1975875236 @default.
• W3113042016 cites W1976650998 @default.
• W3113042016 cites W1978602215 @default.
• W3113042016 cites W1980584878 @default.
• W3113042016 cites W1982106711 @default.
• W3113042016 cites W1982462999 @default.
• W3113042016 cites W1983743860 @default.
• W3113042016 cites W1985962805 @default.
• W3113042016 cites W1989230986 @default.
• W3113042016 cites W1989428356 @default.
• W3113042016 cites W1989658253 @default.
• W3113042016 cites W1992220874 @default.
• W3113042016 cites W1992768781 @default.
• W3113042016 cites W1993020708 @default.
• W3113042016 cites W1993162436 @default.
• W3113042016 cites W1994057593 @default.
• W3113042016 cites W1995864089 @default.
• W3113042016 cites W2001018320 @default.
• W3113042016 cites W2001338687 @default.
• W3113042016 cites W2003774981 @default.
• W3113042016 cites W2004704880 @default.
• W3113042016 cites W2006587369 @default.
• W3113042016 cites W2006682004 @default.
• W3113042016 cites W2011370547 @default.
• W3113042016 cites W2012891879 @default.
• W3113042016 cites W2016618798 @default.
• W3113042016 cites W2016670146 @default.
• W3113042016 cites W2017904618 @default.
• W3113042016 cites W2018457027 @default.
• W3113042016 cites W2019704184 @default.
• W3113042016 cites W2020667221 @default.
• W3113042016 cites W2022480295 @default.
• W3113042016 cites W2022786065 @default.
• W3113042016 cites W2023425646 @default.
• W3113042016 cites W2024710619 @default.
• W3113042016 cites W2024787650 @default.
• W3113042016 cites W2028063483 @default.
• W3113042016 cites W2029942805 @default.
• W3113042016 cites W2030184956 @default.
• W3113042016 cites W2032760352 @default.
• W3113042016 cites W2033125684 @default.
• W3113042016 cites W2033278320 @default.
• W3113042016 cites W2033468145 @default.
• W3113042016 cites W2033598179 @default.
• W3113042016 cites W2033612573 @default.
• W3113042016 cites W2034052150 @default.
• W3113042016 cites W2035133075 @default.
• W3113042016 cites W2036243374 @default.
• W3113042016 cites W2036254354 @default.
• W3113042016 cites W2036453518 @default.
• W3113042016 cites W2037225002 @default.
• W3113042016 cites W2037800265 @default.
• W3113042016 cites W2037958826 @default.
• W3113042016 cites W2038218071 @default.
• W3113042016 cites W2038552054 @default.
• W3113042016 cites W2040041663 @default.
• W3113042016 cites W2041296249 @default.
• W3113042016 cites W2041577840 @default.

• next