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• W3113045379 abstract "Mesenchymal Stromal Cells (MSCs) are fibroblast-like cells of mesodermal origin present in many tissues and which have the potential to differentiate to osteoblasts, adipocytes and chondroblasts. They also have a clear immunosuppressive and tissue regeneration potential. Indeed, the initial classification of MSCs as pluripotent stem cells, has turned into their identification as stromal progenitors. Due to the relatively simple procedures available to expand in vitro large numbers of GMP grade MSCs from a variety of different tissues, many clinical trials have tested their therapeutic potential in vivo . One pathological condition where MSCs have been quite extensively tested is steroid resistant (SR) graft versus host disease (GvHD), a devastating condition that may occur in acute or chronic form following allogeneic hematopoietic stem cell transplantation. The clinical and experimental results obtained have outlined a possible efficacy of MSCs, but unfortunately statistical significance in clinical studies has only rarely been reached and effects have been relatively limited in most cases. Nonetheless, the extremely complex pathogenetic mechanisms at the basis of GvHD, the fact that studies have been conducted often in patients who had been previously treated with multiple lines of therapy, the variable MSC doses and schedules administered in different trials, the lack of validated potency assays and clear biomarkers, the difference in MSC sources and production methods may have been major factors for this lack of clear efficacy in vivo . The heterogeneity of MSCs and their different stromal differentiation potential and biological activity may be better understood through more refined single cell sequencing and proteomic studies, where either an “anti-inflammatory” or a more “immunosuppressive” profile can be identified. We summarize the pathogenic mechanisms of acute and chronic GvHD and the role for MSCs. We suggest that systematic controlled clinical trials still need to be conducted in the most promising clinical settings, using better characterized cells and measuring efficacy with specific biomarkers, before strong conclusions can be drawn about the therapeutic potential of these cells in this context. The same analysis should be applied to other inflammatory, immune or degenerative diseases where MSCs may have a therapeutic potential." @default.
• W3113045379 created "2020-12-21" @default.
• W3113045379 creator A5018208681 @default.
• W3113045379 creator A5051058036 @default.
• W3113045379 date "2020-12-11" @default.
• W3113045379 modified "2023-10-18" @default.
• W3113045379 title "Tolerance to Bone Marrow Transplantation: Do Mesenchymal Stromal Cells Still Have a Future for Acute or Chronic GvHD?" @default.
• W3113045379 cites W1797422316 @default.
• W3113045379 cites W1963621907 @default.
• W3113045379 cites W1970122079 @default.
• W3113045379 cites W1970590929 @default.
• W3113045379 cites W1982408656 @default.
• W3113045379 cites W1986218488 @default.
• W3113045379 cites W1987348882 @default.
• W3113045379 cites W1998650056 @default.
• W3113045379 cites W2008323089 @default.
• W3113045379 cites W2019495971 @default.
• W3113045379 cites W2024088021 @default.
• W3113045379 cites W2025371271 @default.
• W3113045379 cites W2035309698 @default.
• W3113045379 cites W2038399651 @default.
• W3113045379 cites W2042487476 @default.
• W3113045379 cites W2047003816 @default.
• W3113045379 cites W2050875930 @default.
• W3113045379 cites W2056510698 @default.
• W3113045379 cites W2070842082 @default.
• W3113045379 cites W2070855360 @default.
• W3113045379 cites W2082030284 @default.
• W3113045379 cites W2091786014 @default.
• W3113045379 cites W2099443640 @default.
• W3113045379 cites W2116483603 @default.
• W3113045379 cites W2158048826 @default.
• W3113045379 cites W2158256987 @default.
• W3113045379 cites W2162761119 @default.
• W3113045379 cites W2165025975 @default.
• W3113045379 cites W2170334907 @default.
• W3113045379 cites W2201248084 @default.
• W3113045379 cites W2238141562 @default.
• W3113045379 cites W2294785140 @default.
• W3113045379 cites W2427154682 @default.
• W3113045379 cites W2460851798 @default.
• W3113045379 cites W2465027035 @default.
• W3113045379 cites W2499188609 @default.
• W3113045379 cites W2528448343 @default.
• W3113045379 cites W2556848103 @default.
• W3113045379 cites W2558668988 @default.
• W3113045379 cites W2586256617 @default.
• W3113045379 cites W2617594540 @default.
• W3113045379 cites W2728529182 @default.
• W3113045379 cites W2743476964 @default.
• W3113045379 cites W2752406006 @default.
• W3113045379 cites W2763250735 @default.
• W3113045379 cites W2765810838 @default.
• W3113045379 cites W2769010773 @default.
• W3113045379 cites W2769990542 @default.
• W3113045379 cites W2770867911 @default.
• W3113045379 cites W2780122844 @default.
• W3113045379 cites W2780607073 @default.
• W3113045379 cites W2789317630 @default.
• W3113045379 cites W2792936145 @default.
• W3113045379 cites W2801742381 @default.
• W3113045379 cites W2807680113 @default.
• W3113045379 cites W2883415588 @default.
• W3113045379 cites W2891962900 @default.
• W3113045379 cites W2902849850 @default.
• W3113045379 cites W2905083850 @default.
• W3113045379 cites W2908578503 @default.
• W3113045379 cites W2913905282 @default.
• W3113045379 cites W2913962492 @default.
• W3113045379 cites W2920344309 @default.
• W3113045379 cites W2926032340 @default.
• W3113045379 cites W2943293743 @default.
• W3113045379 cites W2956415166 @default.
• W3113045379 cites W2959357913 @default.
• W3113045379 cites W2969519229 @default.
• W3113045379 cites W2972161970 @default.
• W3113045379 cites W2973068260 @default.
• W3113045379 cites W2974291499 @default.
• W3113045379 cites W2974941099 @default.
• W3113045379 cites W2978713746 @default.
• W3113045379 cites W2981453782 @default.
• W3113045379 cites W2990217764 @default.
• W3113045379 cites W2991089444 @default.
• W3113045379 cites W2991416247 @default.
• W3113045379 cites W2991506351 @default.
• W3113045379 cites W2993278748 @default.
• W3113045379 cites W2993334270 @default.
• W3113045379 cites W3004031232 @default.
• W3113045379 cites W3004044398 @default.
• W3113045379 cites W3004433996 @default.
• W3113045379 cites W3004505539 @default.
• W3113045379 cites W3007126308 @default.
• W3113045379 cites W3009082681 @default.
• W3113045379 cites W3015136999 @default.
• W3113045379 cites W3017383148 @default.
• W3113045379 cites W3022561310 @default.
• W3113045379 cites W3027917897 @default.
• W3113045379 cites W3030233660 @default.
• W3113045379 cites W3033725403 @default.
• W3113045379 cites W3034213215 @default.

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