FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113045396> ?p ?o ?g. }

• W3113045396 endingPage "1883" @default.
• W3113045396 startingPage "1872" @default.
• W3113045396 abstract "O-linked N-acetylglucosaminylation (O-GlcNAcylation), controlled by O-GlcNAcase (OGA) and O-GlcNAc transferase (OGT), is an important post-translational modification of eukaryotic proteins and plays an essential role in regulating gut inflammation. Gut microbiota encode various enzymes involved in O-GlcNAcylation. However, the characteristics, abundance and function of these enzymes are unknown.We first investigated the structure and taxonomic distribution of bacterial OGAs and OGTs. Then, we performed metagenomic analysis to explore the OGA genes abundance in health samples and different diseases. Finally, we employed in vitro and in vivo experiments to determine the effects and mechanisms of bacterial OGAs to hydrolyse O-GlcNAcylated proteins in host cells and suppress inflammatory response in the gut.We found OGAs, instead of OGTs, are enriched in Bacteroidetes and Firmicutes, the major bacterial divisions in the human gut. Most bacterial OGAs are secreted enzymes with the same conserved catalytic domain as human OGAs. A pooled analysis on 1999 metagenomic samples encompassed six diseases revealed that bacterial OGA genes were conserved in healthy human gut with high abundance, and reduced exclusively in ulcerative colitis. In vitro studies showed that bacterial OGAs could hydrolyse O-GlcNAcylated proteins in host cells, including O-GlcNAcylated NF-κB-p65 subunit, which is important for activating NF-κB signalling. In vivo studies demonstrated that gut bacteria-derived OGAs could protect mice from chemically induced colonic inflammation through hydrolysing O-GlcNAcylated proteins.Our results reveal a previously unrecognised enzymatic activity by which gut microbiota influence intestinal physiology and highlight bacterial OGAs as a promising therapeutic strategy in colonic inflammation." @default.
• W3113045396 created "2020-12-21" @default.
• W3113045396 creator A5002959234 @default.
• W3113045396 creator A5006219225 @default.
• W3113045396 creator A5016046583 @default.
• W3113045396 creator A5028727120 @default.
• W3113045396 creator A5030389698 @default.
• W3113045396 creator A5056302980 @default.
• W3113045396 creator A5056957943 @default.
• W3113045396 creator A5083626067 @default.
• W3113045396 date "2020-12-12" @default.
• W3113045396 modified "2023-10-14" @default.
• W3113045396 title "Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice" @default.
• W3113045396 cites W1835020024 @default.
• W3113045396 cites W1896434730 @default.
• W3113045396 cites W1964027278 @default.
• W3113045396 cites W1978709058 @default.
• W3113045396 cites W1993052072 @default.
• W3113045396 cites W1996110624 @default.
• W3113045396 cites W1998523743 @default.
• W3113045396 cites W2001561488 @default.
• W3113045396 cites W2003085334 @default.
• W3113045396 cites W2004549986 @default.
• W3113045396 cites W2006871857 @default.
• W3113045396 cites W2023615726 @default.
• W3113045396 cites W2035779227 @default.
• W3113045396 cites W2053975578 @default.
• W3113045396 cites W2071841602 @default.
• W3113045396 cites W2097124003 @default.
• W3113045396 cites W2103869732 @default.
• W3113045396 cites W2113552312 @default.
• W3113045396 cites W2115921802 @default.
• W3113045396 cites W2120106881 @default.
• W3113045396 cites W2124817677 @default.
• W3113045396 cites W2125826054 @default.
• W3113045396 cites W2128769815 @default.
• W3113045396 cites W2131415145 @default.
• W3113045396 cites W2156322986 @default.
• W3113045396 cites W2158953193 @default.
• W3113045396 cites W2164029759 @default.
• W3113045396 cites W2515435336 @default.
• W3113045396 cites W2533422282 @default.
• W3113045396 cites W2592844806 @default.
• W3113045396 cites W2605025237 @default.
• W3113045396 cites W2613539552 @default.
• W3113045396 cites W2810318858 @default.
• W3113045396 cites W2886401819 @default.
• W3113045396 cites W2893248012 @default.
• W3113045396 cites W2912990896 @default.
• W3113045396 cites W2921986958 @default.
• W3113045396 cites W2947189704 @default.
• W3113045396 cites W2952656298 @default.
• W3113045396 cites W2953291795 @default.
• W3113045396 doi "https://doi.org/10.1136/gutjnl-2020-322468" @default.
• W3113045396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8458092" @default.
• W3113045396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33310751" @default.
• W3113045396 hasPublicationYear "2020" @default.
• W3113045396 type Work @default.
• W3113045396 sameAs 3113045396 @default.
• W3113045396 citedByCount "16" @default.
• W3113045396 countsByYear W31130453962021 @default.
• W3113045396 countsByYear W31130453962022 @default.
• W3113045396 countsByYear W31130453962023 @default.
• W3113045396 crossrefType "journal-article" @default.
• W3113045396 hasAuthorship W3113045396A5002959234 @default.
• W3113045396 hasAuthorship W3113045396A5006219225 @default.
• W3113045396 hasAuthorship W3113045396A5016046583 @default.
• W3113045396 hasAuthorship W3113045396A5028727120 @default.
• W3113045396 hasAuthorship W3113045396A5030389698 @default.
• W3113045396 hasAuthorship W3113045396A5056302980 @default.
• W3113045396 hasAuthorship W3113045396A5056957943 @default.
• W3113045396 hasAuthorship W3113045396A5083626067 @default.
• W3113045396 hasBestOaLocation W31130453961 @default.
• W3113045396 hasConcept C104317684 @default.
• W3113045396 hasConcept C142724271 @default.
• W3113045396 hasConcept C143121216 @default.
• W3113045396 hasConcept C15151743 @default.
• W3113045396 hasConcept C181199279 @default.
• W3113045396 hasConcept C203014093 @default.
• W3113045396 hasConcept C207001950 @default.
• W3113045396 hasConcept C2775862500 @default.
• W3113045396 hasConcept C2777385719 @default.
• W3113045396 hasConcept C2777695942 @default.
• W3113045396 hasConcept C2779134260 @default.
• W3113045396 hasConcept C2780479503 @default.
• W3113045396 hasConcept C42062724 @default.
• W3113045396 hasConcept C523546767 @default.
• W3113045396 hasConcept C539455810 @default.
• W3113045396 hasConcept C54355233 @default.
• W3113045396 hasConcept C55493867 @default.
• W3113045396 hasConcept C71924100 @default.
• W3113045396 hasConcept C86803240 @default.
• W3113045396 hasConcept C89423630 @default.
• W3113045396 hasConcept C91478284 @default.
• W3113045396 hasConceptScore W3113045396C104317684 @default.
• W3113045396 hasConceptScore W3113045396C142724271 @default.
• W3113045396 hasConceptScore W3113045396C143121216 @default.
• W3113045396 hasConceptScore W3113045396C15151743 @default.

• next