Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113045701> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W3113045701 endingPage "182" @default.
- W3113045701 startingPage "173" @default.
- W3113045701 abstract "Progesterone, which is secreted from the corpus luteum, is indispensable for the establishment and maintenance of pregnancy. The orphan nuclear receptor subfamily 5 group A member 2 (NR5A2) is a regulator of murine luteinization, but neither its regulation nor its role in the fully differentiated, mature corpus luteum (CL) have been described. Therefore, the goal of this study was to profile abundance and investigate the regulation and functions of NR5A2 in the bovine CL. Treatment of cultured luteal steroidogenic cells with a pharmacological inhibitor of NR5A2 decreased progesterone production and tended to decrease abundance of HSD3B1 mRNA. Luteal NR5A2 mRNA increased and NR5A2 protein tended to increase between days 4 and 6 of the estrous cycle, coincident with increased steroidogenic capacity of the CL. Luteal NR5A2 mRNA decreased by 8 h after prostaglandin (PG) F2A injection. During early pregnancy, luteal NR5A2 mRNA was less on days 20 and 23 compared to day 14, but protein abundance did not change. Neither 1 nor 10 ng/mL interferon tau (IFNT) altered NR5A2 abundance in cultured luteal steroidogenic cells, but 10 ng/mL PGF2A decreased NR5A2. Because of discrepancies between mRNA and protein abundance of NR5A2, regulation by miRNA that changed during early pregnancy was investigated. miR-27b-3p, miR-432-5p, and miR-369-3p mimics decreased NR5A2 protein abundance and miR-369-3p also inhibited progesterone production. Overall, the results of this study show that NR5A2 may be maintained by miRNA during early pregnancy and may be an important regulator of luteal progesterone production." @default.
- W3113045701 created "2020-12-21" @default.
- W3113045701 creator A5019136135 @default.
- W3113045701 creator A5027215964 @default.
- W3113045701 creator A5034377681 @default.
- W3113045701 creator A5081121758 @default.
- W3113045701 date "2021-02-01" @default.
- W3113045701 modified "2023-09-27" @default.
- W3113045701 title "NR5A2 and potential regulatory miRNAs in the bovine CL during early pregnancy" @default.
- W3113045701 cites W1998191274 @default.
- W3113045701 cites W2000497214 @default.
- W3113045701 cites W2002959545 @default.
- W3113045701 cites W2004490930 @default.
- W3113045701 cites W2080474281 @default.
- W3113045701 cites W2118499816 @default.
- W3113045701 cites W2134629862 @default.
- W3113045701 cites W2137889453 @default.
- W3113045701 cites W2148245918 @default.
- W3113045701 cites W2317872568 @default.
- W3113045701 cites W2613544517 @default.
- W3113045701 cites W2779543926 @default.
- W3113045701 cites W2925146825 @default.
- W3113045701 cites W3007196770 @default.
- W3113045701 cites W3015721350 @default.
- W3113045701 doi "https://doi.org/10.1530/rep-20-0009" @default.
- W3113045701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33320828" @default.
- W3113045701 hasPublicationYear "2021" @default.
- W3113045701 type Work @default.
- W3113045701 sameAs 3113045701 @default.
- W3113045701 citedByCount "3" @default.
- W3113045701 countsByYear W31130457012022 @default.
- W3113045701 countsByYear W31130457012023 @default.
- W3113045701 crossrefType "journal-article" @default.
- W3113045701 hasAuthorship W3113045701A5019136135 @default.
- W3113045701 hasAuthorship W3113045701A5027215964 @default.
- W3113045701 hasAuthorship W3113045701A5034377681 @default.
- W3113045701 hasAuthorship W3113045701A5081121758 @default.
- W3113045701 hasBestOaLocation W31130457011 @default.
- W3113045701 hasConcept C104317684 @default.
- W3113045701 hasConcept C126322002 @default.
- W3113045701 hasConcept C134018914 @default.
- W3113045701 hasConcept C143228043 @default.
- W3113045701 hasConcept C145059251 @default.
- W3113045701 hasConcept C187785154 @default.
- W3113045701 hasConcept C1998276 @default.
- W3113045701 hasConcept C201716435 @default.
- W3113045701 hasConcept C2776608385 @default.
- W3113045701 hasConcept C2778324911 @default.
- W3113045701 hasConcept C55493867 @default.
- W3113045701 hasConcept C63932345 @default.
- W3113045701 hasConcept C6929976 @default.
- W3113045701 hasConcept C71924100 @default.
- W3113045701 hasConcept C86339819 @default.
- W3113045701 hasConcept C86803240 @default.
- W3113045701 hasConceptScore W3113045701C104317684 @default.
- W3113045701 hasConceptScore W3113045701C126322002 @default.
- W3113045701 hasConceptScore W3113045701C134018914 @default.
- W3113045701 hasConceptScore W3113045701C143228043 @default.
- W3113045701 hasConceptScore W3113045701C145059251 @default.
- W3113045701 hasConceptScore W3113045701C187785154 @default.
- W3113045701 hasConceptScore W3113045701C1998276 @default.
- W3113045701 hasConceptScore W3113045701C201716435 @default.
- W3113045701 hasConceptScore W3113045701C2776608385 @default.
- W3113045701 hasConceptScore W3113045701C2778324911 @default.
- W3113045701 hasConceptScore W3113045701C55493867 @default.
- W3113045701 hasConceptScore W3113045701C63932345 @default.
- W3113045701 hasConceptScore W3113045701C6929976 @default.
- W3113045701 hasConceptScore W3113045701C71924100 @default.
- W3113045701 hasConceptScore W3113045701C86339819 @default.
- W3113045701 hasConceptScore W3113045701C86803240 @default.
- W3113045701 hasIssue "2" @default.
- W3113045701 hasLocation W31130457011 @default.
- W3113045701 hasLocation W31130457012 @default.
- W3113045701 hasOpenAccess W3113045701 @default.
- W3113045701 hasPrimaryLocation W31130457011 @default.
- W3113045701 hasRelatedWork W1971486389 @default.
- W3113045701 hasRelatedWork W1983723653 @default.
- W3113045701 hasRelatedWork W1986238933 @default.
- W3113045701 hasRelatedWork W2041501575 @default.
- W3113045701 hasRelatedWork W2132670049 @default.
- W3113045701 hasRelatedWork W2142400691 @default.
- W3113045701 hasRelatedWork W2163933792 @default.
- W3113045701 hasRelatedWork W68743933 @default.
- W3113045701 hasRelatedWork W2342011550 @default.
- W3113045701 hasRelatedWork W2613644619 @default.
- W3113045701 hasVolume "161" @default.
- W3113045701 isParatext "false" @default.
- W3113045701 isRetracted "false" @default.
- W3113045701 magId "3113045701" @default.
- W3113045701 workType "article" @default.