Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113055450> ?p ?o ?g. }
- W3113055450 abstract "Abstract The transcription factor MYC is deregulated in almost all human cancers, especially in aggressive lymphomas, through chromosomal translocation, amplification, and transcription hyperactivation. Here, we report that high expression of tribbles homologue 3 (TRIB3) positively correlates with elevated MYC expression in lymphoma specimens; TRIB3 deletion attenuates the initiation and progression of MYC-driven lymphoma by reducing MYC expression. Mechanistically, TRIB3 interacts with MYC to suppress E3 ubiquitin ligase UBE3B-mediated MYC ubiquitination and degradation, which enhances MYC transcriptional activity, causing high proliferation and self-renewal of lymphoma cells. Use of a peptide to disturb the TRIB3-MYC interaction together with doxorubicin reduces the tumor burden in Myc Eμ mice and patient-derived xenografts. The pathophysiological relevance of UBE3B, TRIB3 and MYC is further demonstrated in human lymphoma. Our study highlights a key mechanism for controlling MYC expression and a potential therapeutic option for treating lymphomas with high TRIB3-MYC expression." @default.
- W3113055450 created "2020-12-21" @default.
- W3113055450 creator A5008008825 @default.
- W3113055450 creator A5017067157 @default.
- W3113055450 creator A5017100408 @default.
- W3113055450 creator A5022387395 @default.
- W3113055450 creator A5035653729 @default.
- W3113055450 creator A5043288269 @default.
- W3113055450 creator A5048297033 @default.
- W3113055450 creator A5062071376 @default.
- W3113055450 creator A5064402983 @default.
- W3113055450 creator A5070812231 @default.
- W3113055450 creator A5072529549 @default.
- W3113055450 creator A5078851874 @default.
- W3113055450 creator A5079687120 @default.
- W3113055450 creator A5081608648 @default.
- W3113055450 creator A5083045938 @default.
- W3113055450 creator A5087255205 @default.
- W3113055450 date "2020-12-09" @default.
- W3113055450 modified "2023-10-12" @default.
- W3113055450 title "TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation" @default.
- W3113055450 cites W1458331036 @default.
- W3113055450 cites W1481314844 @default.
- W3113055450 cites W1560204041 @default.
- W3113055450 cites W1593555249 @default.
- W3113055450 cites W1814084293 @default.
- W3113055450 cites W1897425543 @default.
- W3113055450 cites W1965638470 @default.
- W3113055450 cites W1977377125 @default.
- W3113055450 cites W1986295376 @default.
- W3113055450 cites W1991331097 @default.
- W3113055450 cites W1992450378 @default.
- W3113055450 cites W1995474832 @default.
- W3113055450 cites W2000179223 @default.
- W3113055450 cites W2015815772 @default.
- W3113055450 cites W2020419538 @default.
- W3113055450 cites W2021536610 @default.
- W3113055450 cites W2032972450 @default.
- W3113055450 cites W2042066283 @default.
- W3113055450 cites W2044546177 @default.
- W3113055450 cites W2050778114 @default.
- W3113055450 cites W2056377340 @default.
- W3113055450 cites W2067772304 @default.
- W3113055450 cites W2071845076 @default.
- W3113055450 cites W2081141657 @default.
- W3113055450 cites W2091429549 @default.
- W3113055450 cites W2092664001 @default.
- W3113055450 cites W2106119346 @default.
- W3113055450 cites W2108258898 @default.
- W3113055450 cites W2119147717 @default.
- W3113055450 cites W2123798589 @default.
- W3113055450 cites W2124361787 @default.
- W3113055450 cites W2130227763 @default.
- W3113055450 cites W2146915309 @default.
- W3113055450 cites W2153686473 @default.
- W3113055450 cites W2162244898 @default.
- W3113055450 cites W2162520885 @default.
- W3113055450 cites W2172697812 @default.
- W3113055450 cites W2205700110 @default.
- W3113055450 cites W2300552754 @default.
- W3113055450 cites W2405142225 @default.
- W3113055450 cites W2503456027 @default.
- W3113055450 cites W2512462528 @default.
- W3113055450 cites W2518115798 @default.
- W3113055450 cites W2553908226 @default.
- W3113055450 cites W2602591481 @default.
- W3113055450 cites W2606047684 @default.
- W3113055450 cites W2612676865 @default.
- W3113055450 cites W2692768525 @default.
- W3113055450 cites W2791431414 @default.
- W3113055450 cites W2793187747 @default.
- W3113055450 cites W2802615563 @default.
- W3113055450 cites W2897151987 @default.
- W3113055450 cites W4248583329 @default.
- W3113055450 doi "https://doi.org/10.1038/s41467-020-20107-1" @default.
- W3113055450 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7725785" @default.
- W3113055450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33298911" @default.
- W3113055450 hasPublicationYear "2020" @default.
- W3113055450 type Work @default.
- W3113055450 sameAs 3113055450 @default.
- W3113055450 citedByCount "23" @default.
- W3113055450 countsByYear W31130554502021 @default.
- W3113055450 countsByYear W31130554502022 @default.
- W3113055450 countsByYear W31130554502023 @default.
- W3113055450 crossrefType "journal-article" @default.
- W3113055450 hasAuthorship W3113055450A5008008825 @default.
- W3113055450 hasAuthorship W3113055450A5017067157 @default.
- W3113055450 hasAuthorship W3113055450A5017100408 @default.
- W3113055450 hasAuthorship W3113055450A5022387395 @default.
- W3113055450 hasAuthorship W3113055450A5035653729 @default.
- W3113055450 hasAuthorship W3113055450A5043288269 @default.
- W3113055450 hasAuthorship W3113055450A5048297033 @default.
- W3113055450 hasAuthorship W3113055450A5062071376 @default.
- W3113055450 hasAuthorship W3113055450A5064402983 @default.
- W3113055450 hasAuthorship W3113055450A5070812231 @default.
- W3113055450 hasAuthorship W3113055450A5072529549 @default.
- W3113055450 hasAuthorship W3113055450A5078851874 @default.
- W3113055450 hasAuthorship W3113055450A5079687120 @default.
- W3113055450 hasAuthorship W3113055450A5081608648 @default.
- W3113055450 hasAuthorship W3113055450A5083045938 @default.