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• W3113075802 startingPage "82" @default.
• W3113075802 abstract "The establishment and maintenance of chromatin domains shape the epigenetic memory of a cell, with the methylation of histone H3 lysine 9 (H3K9me) defining transcriptionally silent heterochromatin. We show here that the C. elegans SET-25 (SUV39/G9a) histone methyltransferase (HMT), which catalyzes H3K9me1, me2 and me3, can establish repressed chromatin domains de novo , unlike the SETDB1 homolog MET-2. Thus, SET-25 is needed to silence novel insertions of RNA or DNA transposons, and repress tissue-specific genes de novo during development. We identify two partially redundant pathways that recruit SET-25 to its targets. One pathway requires LIN-61 (L3MBTL2), which uses its four MBT domains to bind the H3K9me2 deposited by MET-2. The second pathway functions independently of MET-2 and involves the somatic Argonaute NRDE-3 and small RNAs. This pathway targets primarily highly conserved RNA and DNA transposons. These redundant SET-25 targeting pathways (MET-2–LIN-61–SET-25 and NRDE-3–SET-25) ensure repression of intact transposons and de novo insertions, while MET-2 can act alone to repress simple and satellite repeats. Removal of both pathways in the met-2;nrde-3 double mutant leads to the loss of somatic H3K9me2 and me3 and the synergistic derepression of transposons in embryos, strongly elevating embryonic lethality." @default.
• W3113075802 created "2020-12-21" @default.
• W3113075802 creator A5024163207 @default.
• W3113075802 creator A5044171703 @default.
• W3113075802 creator A5047209319 @default.
• W3113075802 creator A5050741353 @default.
• W3113075802 creator A5060840199 @default.
• W3113075802 creator A5082924650 @default.
• W3113075802 date "2020-12-10" @default.
• W3113075802 modified "2023-09-23" @default.
• W3113075802 title "Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression" @default.
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