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- W3113104699 startingPage "105363" @default.
- W3113104699 abstract "Major depressive disorder (MDD) is the foremost cause of global disability, being responsible for enormous personal, societal, and economical costs. Importantly, existing pharmacological treatments for MDD are partially or totally ineffective in a large segment of patients. As such, the search for novel antidepressant drug targets, anchored on a clear understanding of the etiological and pathophysiological mechanisms underpinning MDD, becomes of the utmost importance. The adenosinergic system, a highly conserved neuromodulatory system, appears as a promising novel target, given both its regulatory actions over many MDD-affected systems and processes. With this goal in mind, we herein review the evidence concerning the role of adenosine as a potential player in pathophysiology and treatment of MDD, combining data from both human and animal studies. Altogether, evidence supports the assertions that the adenosinergic system is altered in both MDD patients and animal models, and that drugs targeting this system have considerable potential as putative antidepressants. Furthermore, evidence also suggests that modifications in adenosine signaling may have a key role in the effects of several pharmacological and non-pharmacological antidepressant treatments with demonstrated efficacy, such as electroconvulsive shock, sleep deprivation, and deep brain stimulation. Lastly, it becomes clear from the available literature that there is yet much to study regarding the role of the adenosinergic system in the pathophysiology and treatment of MDD, and we suggest several avenues of research that are likely to prove fruitful." @default.
- W3113104699 created "2020-12-21" @default.
- W3113104699 creator A5013341958 @default.
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- W3113104699 creator A5027568151 @default.
- W3113104699 creator A5053858250 @default.
- W3113104699 creator A5076574729 @default.
- W3113104699 creator A5091606743 @default.
- W3113104699 date "2021-01-01" @default.
- W3113104699 modified "2023-10-16" @default.
- W3113104699 title "Of adenosine and the blues: The adenosinergic system in the pathophysiology and treatment of major depressive disorder" @default.
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