FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113113105> ?p ?o ?g. }

• W3113113105 abstract "Abstract Transdifferentiation of human non-muscle cells directly into myogenic cells by forced expression of MyoD represents one route to obtain highly desirable human myogenic cells. However, functional properties of the tissue constructs derived from these transdifferentiated cells have been rarely studied. Here, we report that three-dimensional (3D) tissue constructs engineered with iMyoD-hTERT-NHDFs, normal human dermal fibroblasts transduced with genes encoding human telomerase reverse transcriptase and doxycycline-inducible MyoD, generate detectable contractile forces in response to electrical stimuli upon MyoD expression. Withdrawal of doxycycline in the middle of 3D culture results in 3.05 and 2.28 times increases in twitch and tetanic forces, respectively, suggesting that temporally-controlled MyoD expression benefits functional myogenic differentiation of transdifferentiated myoblast-like cells. Treatment with CHIR99021, a Wnt activator, and DAPT, a Notch inhibitor, leads to further enhanced contractile forces. The ability of these abundant and potentially patient-specific and disease-specific cells to develop into functional skeletal muscle constructs makes them highly valuable for many applications, such as disease modeling." @default.
• W3113113105 created "2020-12-21" @default.
• W3113113105 creator A5019302568 @default.
• W3113113105 creator A5064273027 @default.
• W3113113105 date "2020-12-16" @default.
• W3113113105 modified "2023-10-18" @default.
• W3113113105 title "Functional skeletal muscle constructs from transdifferentiated human fibroblasts" @default.
• W3113113105 cites W1517051009 @default.
• W3113113105 cites W176034906 @default.
• W3113113105 cites W1891826212 @default.
• W3113113105 cites W1980606567 @default.
• W3113113105 cites W1990897270 @default.
• W3113113105 cites W1993177677 @default.
• W3113113105 cites W1996339633 @default.
• W3113113105 cites W2004396725 @default.
• W3113113105 cites W2009110094 @default.
• W3113113105 cites W2059556539 @default.
• W3113113105 cites W2075808770 @default.
• W3113113105 cites W2093188014 @default.
• W3113113105 cites W2112010708 @default.
• W3113113105 cites W2115235864 @default.
• W3113113105 cites W2117915749 @default.
• W3113113105 cites W2127197885 @default.
• W3113113105 cites W2139581284 @default.
• W3113113105 cites W2140692553 @default.
• W3113113105 cites W2146138975 @default.
• W3113113105 cites W2148088341 @default.
• W3113113105 cites W2156131965 @default.
• W3113113105 cites W2159670921 @default.
• W3113113105 cites W2166257330 @default.
• W3113113105 cites W2171103133 @default.
• W3113113105 cites W2312648644 @default.
• W3113113105 cites W2401496253 @default.
• W3113113105 cites W2579625880 @default.
• W3113113105 cites W2580942016 @default.
• W3113113105 cites W2587586269 @default.
• W3113113105 cites W2736441736 @default.
• W3113113105 cites W2739760050 @default.
• W3113113105 cites W2765130136 @default.
• W3113113105 cites W2769276755 @default.
• W3113113105 cites W2774136216 @default.
• W3113113105 cites W2783841708 @default.
• W3113113105 cites W2802378500 @default.
• W3113113105 cites W2888336284 @default.
• W3113113105 cites W2921426074 @default.
• W3113113105 cites W2923772281 @default.
• W3113113105 cites W2986303680 @default.
• W3113113105 cites W2995378687 @default.
• W3113113105 cites W3004227146 @default.
• W3113113105 cites W4210437605 @default.
• W3113113105 doi "https://doi.org/10.1038/s41598-020-78987-8" @default.
• W3113113105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7744552" @default.
• W3113113105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33328524" @default.
• W3113113105 hasPublicationYear "2020" @default.
• W3113113105 type Work @default.
• W3113113105 sameAs 3113113105 @default.
• W3113113105 citedByCount "5" @default.
• W3113113105 countsByYear W31131131052021 @default.
• W3113113105 countsByYear W31131131052022 @default.
• W3113113105 crossrefType "journal-article" @default.
• W3113113105 hasAuthorship W3113113105A5019302568 @default.
• W3113113105 hasAuthorship W3113113105A5064273027 @default.
• W3113113105 hasBestOaLocation W31131131051 @default.
• W3113113105 hasConcept C104317684 @default.
• W3113113105 hasConcept C125593758 @default.
• W3113113105 hasConcept C134018914 @default.
• W3113113105 hasConcept C185592680 @default.
• W3113113105 hasConcept C207200792 @default.
• W3113113105 hasConcept C2777179404 @default.
• W3113113105 hasConcept C2778106681 @default.
• W3113113105 hasConcept C2779959927 @default.
• W3113113105 hasConcept C28328180 @default.
• W3113113105 hasConcept C2909166674 @default.
• W3113113105 hasConcept C3763915 @default.
• W3113113105 hasConcept C501593827 @default.
• W3113113105 hasConcept C55493867 @default.
• W3113113105 hasConcept C60870556 @default.
• W3113113105 hasConcept C86803240 @default.
• W3113113105 hasConcept C94581717 @default.
• W3113113105 hasConcept C95444343 @default.
• W3113113105 hasConceptScore W3113113105C104317684 @default.
• W3113113105 hasConceptScore W3113113105C125593758 @default.
• W3113113105 hasConceptScore W3113113105C134018914 @default.
• W3113113105 hasConceptScore W3113113105C185592680 @default.
• W3113113105 hasConceptScore W3113113105C207200792 @default.
• W3113113105 hasConceptScore W3113113105C2777179404 @default.
• W3113113105 hasConceptScore W3113113105C2778106681 @default.
• W3113113105 hasConceptScore W3113113105C2779959927 @default.
• W3113113105 hasConceptScore W3113113105C28328180 @default.
• W3113113105 hasConceptScore W3113113105C2909166674 @default.
• W3113113105 hasConceptScore W3113113105C3763915 @default.
• W3113113105 hasConceptScore W3113113105C501593827 @default.
• W3113113105 hasConceptScore W3113113105C55493867 @default.
• W3113113105 hasConceptScore W3113113105C60870556 @default.
• W3113113105 hasConceptScore W3113113105C86803240 @default.
• W3113113105 hasConceptScore W3113113105C94581717 @default.
• W3113113105 hasConceptScore W3113113105C95444343 @default.
• W3113113105 hasIssue "1" @default.
• W3113113105 hasLocation W31131131051 @default.
• W3113113105 hasLocation W31131131052 @default.

• next