Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113130160> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W3113130160 endingPage "755" @default.
- W3113130160 startingPage "755" @default.
- W3113130160 abstract "Fedratinib hydrochloride is a selective Janus kinase 2 (JAK2) inhibitor approved by the U.S. Food and Drug Administration (FDA) in August 2019 for intermediate- 2 or high-risk primary or secondary myelofibrosis. The approval of this novel oral agent was based on the phase II and III JAKARTA-2 and JAKARTA trials, which both showed significant reduction in splenomegaly and myelofibrosis symptom burden. The most common adverse effects associated with fedratinib include anemia, gastrointestinal symptoms and elevation in liver transaminases. Early clinical trial data was concerning for an increased incidence of Wernicke's encephalopathy (WE), which led the FDA to place a clinical hold on further drug development. However, upon further investigation it was determined that there was no clear evidence that fedratinib causes WE, and the clinical hold was lifted in 2017. This inclusive review provides insight into the pharmacology, safety and efficacy, and future direction of fedratinib use in myeloproliferative neoplasms." @default.
- W3113130160 created "2020-12-21" @default.
- W3113130160 creator A5002461889 @default.
- W3113130160 creator A5016211158 @default.
- W3113130160 creator A5060316201 @default.
- W3113130160 creator A5067521829 @default.
- W3113130160 creator A5068410542 @default.
- W3113130160 creator A5084588977 @default.
- W3113130160 date "2020-01-01" @default.
- W3113130160 modified "2023-09-25" @default.
- W3113130160 title "Fedratinib hydrochloride to treat intermediate-2 or high-risk primary or secondary myelofibrosis" @default.
- W3113130160 doi "https://doi.org/10.1358/dot.2020.56.12.3230206" @default.
- W3113130160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33332482" @default.
- W3113130160 hasPublicationYear "2020" @default.
- W3113130160 type Work @default.
- W3113130160 sameAs 3113130160 @default.
- W3113130160 citedByCount "1" @default.
- W3113130160 countsByYear W31131301602022 @default.
- W3113130160 crossrefType "journal-article" @default.
- W3113130160 hasAuthorship W3113130160A5002461889 @default.
- W3113130160 hasAuthorship W3113130160A5016211158 @default.
- W3113130160 hasAuthorship W3113130160A5060316201 @default.
- W3113130160 hasAuthorship W3113130160A5067521829 @default.
- W3113130160 hasAuthorship W3113130160A5068410542 @default.
- W3113130160 hasAuthorship W3113130160A5084588977 @default.
- W3113130160 hasConcept C109159458 @default.
- W3113130160 hasConcept C126322002 @default.
- W3113130160 hasConcept C197934379 @default.
- W3113130160 hasConcept C2776112149 @default.
- W3113130160 hasConcept C2778080410 @default.
- W3113130160 hasConcept C2778248108 @default.
- W3113130160 hasConcept C2780007613 @default.
- W3113130160 hasConcept C2780035454 @default.
- W3113130160 hasConcept C2780076729 @default.
- W3113130160 hasConcept C28328180 @default.
- W3113130160 hasConcept C535046627 @default.
- W3113130160 hasConcept C54355233 @default.
- W3113130160 hasConcept C71924100 @default.
- W3113130160 hasConcept C86803240 @default.
- W3113130160 hasConcept C90924648 @default.
- W3113130160 hasConcept C98274493 @default.
- W3113130160 hasConceptScore W3113130160C109159458 @default.
- W3113130160 hasConceptScore W3113130160C126322002 @default.
- W3113130160 hasConceptScore W3113130160C197934379 @default.
- W3113130160 hasConceptScore W3113130160C2776112149 @default.
- W3113130160 hasConceptScore W3113130160C2778080410 @default.
- W3113130160 hasConceptScore W3113130160C2778248108 @default.
- W3113130160 hasConceptScore W3113130160C2780007613 @default.
- W3113130160 hasConceptScore W3113130160C2780035454 @default.
- W3113130160 hasConceptScore W3113130160C2780076729 @default.
- W3113130160 hasConceptScore W3113130160C28328180 @default.
- W3113130160 hasConceptScore W3113130160C535046627 @default.
- W3113130160 hasConceptScore W3113130160C54355233 @default.
- W3113130160 hasConceptScore W3113130160C71924100 @default.
- W3113130160 hasConceptScore W3113130160C86803240 @default.
- W3113130160 hasConceptScore W3113130160C90924648 @default.
- W3113130160 hasConceptScore W3113130160C98274493 @default.
- W3113130160 hasIssue "12" @default.
- W3113130160 hasLocation W31131301601 @default.
- W3113130160 hasLocation W31131301602 @default.
- W3113130160 hasOpenAccess W3113130160 @default.
- W3113130160 hasPrimaryLocation W31131301601 @default.
- W3113130160 hasRelatedWork W1540971014 @default.
- W3113130160 hasRelatedWork W2044155269 @default.
- W3113130160 hasRelatedWork W2153832202 @default.
- W3113130160 hasRelatedWork W2519044558 @default.
- W3113130160 hasRelatedWork W2572266241 @default.
- W3113130160 hasRelatedWork W2951069339 @default.
- W3113130160 hasRelatedWork W3025483714 @default.
- W3113130160 hasRelatedWork W4251586583 @default.
- W3113130160 hasRelatedWork W4285743069 @default.
- W3113130160 hasRelatedWork W4294215495 @default.
- W3113130160 hasVolume "56" @default.
- W3113130160 isParatext "false" @default.
- W3113130160 isRetracted "false" @default.
- W3113130160 magId "3113130160" @default.
- W3113130160 workType "article" @default.